Delving into the Latest Updates on Message Pharmaceuticals, Inc. with Synapse

Overview

The diversity of higher-order structure in ribonucleoprotein (RNP) complexes makes them amenable to small-molecule modulation of their biological function. This review will discuss why bacterial RNase P, a simple yet essential ubiquitous and highly conserved RNP enzyme, represents an excellent target for the discovery and development of novel antimicrobials.

Post-transcriptional regulation of TNFα secretion: Identification of a novel series of mRNA binding TNFα inhibitors

Author: Powers, Gordon D. ; Conway, Samuel C. ; Sturgess, Michael A. ; Waggoner, Shelly A. ; Woods, Michael P. ; Green, Alicia ; Giordano, Tony ; Temeles, Gretchen L.

In vitro and in vivo studies have unambiguously demonstrated that the induction of Tumor Necrosis Factor α(TNFα) secretion in response to extracellular stimuli such as LPS is a combination of transcriptional up-regulation of TNFα mRNA and post-transcriptional up-regulation of TNFα polypeptide.The post-transcriptional component of this induction has been shown to be regulated by an AU-rich element within the 3′-UTR of TNFα mRNA.A high throughput screening effort focused on this AU-rich element has identified a series of unique guanylhydrazone compounds that were subsequently shown to inhibit TNFα secretion in a range of assay formats.The mechanism of action of a representative example of these initial guanylhydrazones has been examinedInitial SAR studies have examined both the flexibility and shape of these compounds, leading to a series of second-generation guanylhydrazones displaying both reduced size and charge.

Current opinion in investigational drugs

Bacterial RNase P as a potential target for novel anti-infectives.

Author: Gopalan ; Hatfield C ; Vioque A ; Eder Ps

The diversity of higher-order structure in ribonucleoprotein (RNP) complexes makes them amenable to small-molecule modulation of their biological function. This review will discuss why bacterial RNase P, a simple yet essential ubiquitous and highly conserved RNP enzyme, represents an excellent target for the discovery and development of novel antimicrobials.

100 Deals associated with Message Pharmaceuticals, Inc.

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100 Translational Medicine associated with Message Pharmaceuticals, Inc.

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Pipeline

Pipeline Snapshot as of 20 Dec 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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