Between 0.6% and 22.2% of the global adult male population has a sexual interest in children (SIIC), depending on evaluation methods [1]. SIIC constitutes a major risk factor for child sexual abuse (CSA) and viewing of child sexual abuse material (CSAM) [2]. The true rates of CSA offences cannot be estimated, but self-report studies find 30 times higher rates of child-reported CSA compared to reports from child protection services or police [3].
Engagement in therapy is a protective factor against the risk of child sexual abuse [4] and can lead to reductions in CSAM consumption and severity [5]. Anticipated negative therapist behaviour is associated with less willingness to seek treatment [6]. The fear of being reported by the therapist discourages participation in therapy [7], a concern complicated by mandatory reporting laws in some countries [8]. Negative attitudes towards ISIC are high, and SIIC may be the most stigmatised trait globally [9].
Identifying barriers to treatment for ISIC, and of measures to overcome them, is important to increase therapy engagement, with the goal to improve wellbeing, reduce CSAM consumption, and reduce the risk of CSA offences. Patient anonymity during therapy may play an important role in increasing disclosure of stigmatised traits [10,11]. It remains unclear whether anonymous therapy addresses patient treatment anxieties and therefore increases the comfort or willingness to engage in therapy. To address this research gap, we conduct an anonymous online survey with ISIC to answer the following questions:
RQ1. Can online therapy preferences be identified for minor-attacted individuals and for their therapists?
RQ2. Are there individual factors that predict stigmatized individuals' online therapy preferences? (E.g. Trust, Self-Stigma)
RQ3. Are there differences between the different stigmatized groups', therapists, and general populations' online therapy preferences?
1. Savoie V, Quayle E, Flynn E. Prevalence and correlates of individuals with sexual interest in children: A systematic review. Child Abuse Negl. 2021 May;115:105005.
2. Beier KM, Grundmann D, Kuhle LF, Scherner G, Konrad A, Amelung T. The German Dunkelfeld Project: A Pilot Study to Prevent Child Sexual Abuse and the Use of Child Abusive Images. J Sex Med. 2015 Feb 1;12(2):529-42.
3. Stoltenborgh M, van IJzendoorn MH, Euser EM, Bakermans-Kranenburg MJ. A Global Perspective on Child Sexual Abuse: Meta-Analysis of Prevalence Around the World. Child Maltreat. 2011 May 1;16(2):79-101.
4. Van Deinse TB, Cuddeback GS, Wilson AB, Edwards D, Lambert M. Variation in Criminogenic Risks by Mental Health Symptom Severity: Implications for Mental Health Services and Research. Psychiatr Q. 2021 Mar;92(1):73-84.
5. Schuler M, Gieseler H, Schweder KW, Heyden M von, Beier KM. Characteristics of the Users of Troubled Desire, a Web-Based Self-management App for Individuals With Sexual Interest in Children: Descriptive Analysis of Self-assessment Data. JMIR Mental Health. 2021 Feb 19;8(2):e22277.
6. Jahnke S, McPhail IV, Antfolk J. Stigma processes, psychological distress, and attitudes toward seeking treatment among pedohebephilic people. PLoS One. 2024;19(10):e0312382.
7. Grady MD, Levenson JS, Mesias G, Kavanagh S, Charles J. "I can't talk about that": Stigma and fear as barriers to preventive services for minor-attracted persons. Stigma and Health. 2019;4(4):400-10.
8. Edwards W, Hensley C. Contextualizing Sex Offender Management Legislation and Policy: Evaluating the Problem of Latent Consequences in Community Notification Laws. Int J Offender Ther Comp Criminol. 2001 Feb 1;45(1):83-101.
9. Jahnke S, Imhoff R, Hoyer J. Stigmatization of People with Pedophilia: Two Comparative Surveys. Arch Sex Behav. 2015 Jan 1;44(1):21-34.
10. Fear NT, Seddon R, Jones N, Greenberg N, Wessely S. Does anonymity increase the reporting of mental health symptoms? BMC Public Health. 2012 Sept 17;12(1):797.

Start Date13 May 2025

Sponsor / Collaborator

Deutsches Forschungszentrum für Künstliche Intelligenz GmbH

[+1]

NCT06445153

/ RecruitingNot ApplicableIIT

Digitalized Clinical Decision Support for the Prevention of Postoperative Delirium (POD)

The project aims to improve patient safety, reduce barriers to the implementation of current guideline recommendations, reduce workload in clinics, increase efficiency in work processes and close gaps in care. Subprojects regarding delirium are implementes as well.

Start Date03 Jun 2024

Sponsor / Collaborator

Barmer

[+2]

NCT05949827

/ Active, not recruitingNot ApplicableIIT

Evaluation of the Effect on Nursing Care Specialists of a Device With Specific Light Algorithms to Maintain and Restore Circadian Melatonin Rhythmicity in Critically Ill Patients

The purpose of this study is to investigate the impact of a newly installed device administering a Light Scheduling Algorithm with high circadian effective irradiances to mechanically ventilated patients on the perceived stress among nursing care specialists.
The investigators will further evaluate the impact on commitment to the workplace, meaning of work, and empathy.

Start Date01 Jun 2023

Sponsor / Collaborator

Technical University of Berlin

100 Clinical Results associated with Technical University of Berlin

0 Patents (Medical) associated with Technical University of Berlin

16,887

Literatures (Medical) associated with Technical University of Berlin

01 Apr 2026·HEALTH POLICY

Integrated care in the Baltic countries over a five-year period: an expert-informed cross-country analysis of progress, challenges and future directions

Article

Author: Kasekamp, Kaija ; Behmane, Daiga ; Scarpetti, Giada ; Shuftan, Nathan ; Murauskiene, Liubove ; Polin, Katherine ; Struckmann, Verena

BACKGROUND:

In Estonia, Latvia, and Lithuania, the push for care integration has gained momentum, being seen as an innovative approach to allocate resources more efficiently and improve patient outcomes.

OBJECTIVE:

This study investigates the progress of integrating care in the Baltic countries from 2019 to 2024 to detail key learnings.

METHODS:

We undertook a cross-country study to better understand the progress in care integration in the Baltics with a two-round, 21-item questionnaire on the adoption of integrated care reforms in 2019 and 2024. Responses were analyzed to capture countries' policy environments and their conduciveness to the uptake of integrated care. Country-specific experiences with implementation of care were further explored via case studies of pilot programmes.

RESULTS:

The pace of implementing integrating care varied. Existing barriers, workforce challenges and payment schemes have impeded integration across health and social care. Despite this, political commitment across successive governments to new and innovative service delivery and collaboration for chronic care management underscores an important prerequisite toward achieving more integrated and person-centred healthcare. The three case studies illustrate hurdles that come with shifting care settings and expanding roles for some workers.

CONCLUSIONS:

Integrating care across providers and the social and health sectors is an incremental process that needs long-term political support to address persistent barriers. The Baltic countries' experiences indicate challenges in bringing together stakeholders in areas such as data interoperability, new financing models and reorganization of workforce and skills mixing. Further work should advance evidence on patient-centred solutions for evolving needs.

01 Mar 2026·HEALTH POLICY

Small countries face specific challenges in health workforce sustainability, but policy responses are a testbed for resilience for all countries

Article

Author: Richardson, Erica ; Williams, Gemma A ; van Ginneken, Ewout ; Azzopardi-Muscat, Natasha ; Lorcy, Anne-Charlotte ; Kantaris, Marios ; Rechel, Bernd ; Shuftan, Nathan

While countries across Europe are facing challenges in building and sustaining a health workforce, small countries (official population of under 2 million people) face specific challenges that go beyond resource constraint. Limited population size constrains training capacity, specialist care provision, and career development opportunities, making these systems highly vulnerable to workforce shortages. Experiences in Cyprus, Luxembourg, North Macedonia, and the Caribbean Netherlands illustrate these dynamics. Cyprus and Luxembourg have expanded in-country medical education and postgraduate training to reduce the need for training abroad. In contrast, North Macedonia trains sufficient health professionals but struggles with outmigration. Island territories face additional logistical and geographic barriers. The Caribbean Netherlands rely on rotations and cross-border care for many healthcare services. Small countries are like a microscope that magnifies both the problems and the policy responses and may thus serve as a testbed for all health systems confronting workforce challenges. Small country experiences underscore the need for collaborative solutions to respond to the health workforce crisis, including enhanced training opportunities, mitigation of migration risks and improved retention. Ensuring resilience of the health workforce in the face of demographic and mobility pressures requires effective planning and integrated strategies addressing remuneration, working conditions, and professional development across all roles and sectors.

01 Feb 2026·BIOTECHNOLOGY AND BIOENGINEERING

Self‐Driving Development of Perfusion Processes for Monoclonal Antibody Production

Article

Author: Chethana Janardhana Gadiyar ; Fabian Feidl ; Michael Sokolov ; Alessandro Fagnani ; Jean-Marc Bielser ; Jonathan Souquet ; Claudio Müller ; Mariano Nicolas Cruz Bournazou ; Alessandro Butté ; Moritz von Stosch ; Thomas Vuillemin

ABSTRACT:

The development of autonomous agents in bioprocess development is crucial for advancing biopharma innovation. Time and resources required to develop and transfer a process for clinical material generation can be significantly decreased. While robotics and machine learning have greatly accelerated drug discovery and initial screening, the later stages of development have primarily benefited from experimental automation, lacking advanced computational tools for experimental planning and execution. For example, in the development of new monoclonal antibodies, the search for optimal upstream conditions (such as feeding strategy, pH, temperature, and media composition) is often conducted using sophisticated high‐throughput (HT) mini‐bioreactor systems, while the integration of machine learning tools for experimental design and operation in these systems have not matured accordingly. In this work, we developed an integrated user‐friendly software framework that combines a Bayesian experimental design (BED) algorithm and a cognitive digital twin of the cultivation system. This framework is digitally linked to an advanced 24‐parallel mini‐bioreactor perfusion platform. This results in an autonomous experimental machine capable of: (1) embedding existing process knowledge, (2) learning during experimentation, (3) utilizing information from similar processes, (4) predicting future events, and (5) autonomously operating the parallel bioreactors to achieve challenging objectives. As proof of concept, we present experimental results from a 27 day‐long cultivation including 20‐days operated by the autonomous software agent, which successfully achieved challenging goals such as increasing the viable cell volume (VCV) and maximizing the viability throughout the experiment.

News (Medical) associated with Technical University of Berlin

09 Apr 2024

·www.sciencedaily.com

BESSY II: How pulsed charging enhances the service time of batteries

An improved charging protocol might help lithium-ion batteries to last much longer. Charging with a high-frequency pulsed current reduces aging effects, an international team demonstrated. An improved charging protocol might help lithium-ion batteries to last much longer. Charging with a high-frequency pulsed current reduces ageing effects, an international team demonstrated. The study was led by Philipp Adelhelm (HZB and Humboldt University) in collaboration with teams from the Technical University of Berlin and Aalborg University in Denmark. Experiments at the X-ray source BESSY II were particularly revealing. Lithium-ion batteries are powerful, and they are used everywhere, from electric vehicles to electronic devices. However, their capacity gradually decreases over the course of hundreds of charging cycles. The best commercial lithium-ion batteries with electrodes made of so-called NMC532 (molecular formula: LiNi0.5Mn0.3Co0.2O2) and graphite have a service life of up to eight years. Batteries are usually charged with a constant current flow. But is this really the most favourable method? A new study by Prof Philipp Adelhelm's group at HZB and Humboldt-University Berlin answers this question clearly with no. The study in the journal Advanced Energy Materials analyses the effect of the charging protocol on the service time of the battery. Ageing effects analysed Part of the battery tests were carried out at Aalborg University. The batteries were either charged conventionally with constant current (CC) or with a new charging protocol with pulsed current (PC). Post-mortem analyses revealed clear differences after several charging cycles: In the CC samples, the solid electrolyte interface (SEI) at the anode was significantly thicker, which impaired the capacity. The team also found more cracks in the structure of the NMC532 and graphite electrodes, which also contributed to the loss of capacity. In contrast, PC-charging led to a thinner SEI interface and fewer structural changes in the electrode materials. Synchrotron experiments at BESSY II and PETRA III HZB researcher Dr Yaolin Xu then led the investigation into the lithium-ion cells at Humboldt University and BESSY II with operando Raman spectroscopy and dilatometry as well as X-ray absorption spectroscopy to analyse what happens during charging with different protocols. Supplementary experiments were carried out at the PETRA III synchrotron. "The pulsed current charging promotes the homogeneous distribution of the lithium ions in the graphite and thus reduces the mechanical stress and cracking of the graphite particles. This improves the structural stability of the graphite anode," he concludes. The pulsed charging also suppresses the structural changes of NMC532 cathode materials with less Ni-O bond length variation. The pulse current frequency is crucial However, the frequency of the pulsed current counts: High-frequency PC charging protocols with square-wave current extend the service life of commercial LIBs the most, with a doubled cycle life (with 80% capacity retention) achieved in this study. Co-author Prof. Dr Julia Kowal, an expert in electrical energy storage technology at TU Berlin, emphasises: "Pulsed charging could bring many advantages in terms of the stability of the electrode materials and the interfaces and significantly extend the service life of batteries."

18 Mar 2024

·www.sciencedaily.com

Where quantum computers can score

The traveling salesman problem is considered a prime example of a combinatorial optimization problem. Now a team has shown that a certain class of such problems can actually be solved better and much faster with quantum computers than with conventional methods. The travelling salesman problem is considered a prime example of a combinatorial optimisation problem. Now a Berlin team led by theoretical physicist Prof. Dr. Jens Eisert of Freie Universität Berlin and HZB has shown that a certain class of such problems can actually be solved better and much faster with quantum computers than with conventional methods. Quantum computers use so-called qubits, which are not either zero or one as in conventional logic circuits, but can take on any value in between. These qubits are realised by highly cooled atoms, ions or superconducting circuits, and it is still physically very complex to build a quantum computer with many qubits. However, mathematical methods can already be used to explore what fault-tolerant quantum computers could achieve in the future. "There are a lot of myths about it, and sometimes a certain amount of hot air and hype. But we have approached the issue rigorously, using mathematical methods, and delivered solid results on the subject. Above all, we have clarified in what sense there can be any advantages at all," says Prof. Dr. Jens Eisert, who heads a joint research group at Freie Universität Berlin and Helmholtz-Zentrum Berlin. The well-known problem of the travelling salesman serves as a prime example: A traveller has to visit a number of cities and then return to his home town. Which is the shortest route? Although this problem is easy to understand, it becomes increasingly complex as the number of cities increases and computation time explodes. The travelling salesman problem stands for a group of optimisation problems that are of enormous economic importance, whether they involve railway networks, logistics or resource optimisation. Good enough solutions can be found using approximation methods. The team led by Jens Eisert and his colleague Jean-Pierre Seifert has now used purely analytical methods to evaluate how a quantum computer with qubits could solve this class of problems. A classic thought experiment with pen and paper and a lot of expertise. "We simply assume, regardless of the physical realisation, that there are enough qubits and look at the possibilities of performing computing operations with them," explains Vincent Ulitzsch, a PhD student at the Technical University of Berlin. In doing so, they unveiled similarities to a well-known problem in cryptography, i.e. the encryption of data. "We realised that we could use the Shor algorithm to solve a subclass of these optimisation problems," says Ulitzsch. This means that the computing time no longer "explodes" with the number of cities (exponential, 2N), but only increases polynomially, i.e. with Nx, where x is a constant. The solution obtained in this way is also qualitatively much better than the approximate solution using the conventional algorithm. "We have shown that for a specific but very important and practically relevant class of combinatorial optimisation problems, quantum computers have a fundamental advantage over classical computers for certain instances of the problem," says Eisert.

03 Aug 2023

·www.biospace.com

Agilent Announces Thought Leader Award to Peter Neubauer

Technical University of Berlin researcher recognized for his innovative work in bioprocess engineering SANTA CLARA, Calif.--(BUSINESS WIRE)-- Agilent Technologies Inc. (NYSE: A) announced that Dr. Peter Neubauer has been selected to receive a prestigious Agilent Thought Leader Award. As Chair of Bioprocess Engineering at the Technical University of Berlin, Dr. Neubauer leads innovative research to identify new methods for more efficient bioprocess development, including genetic, cultivation, and analytical tools, with a particular focus on industrial-scale applications. Automation and high throughput are important for the real-time determination of critical quality attributes (CQAs), thus optimizing biotechnological applications. To this end, substantial resources are being directed toward developing process analytical technology (PAT) – a mechanism for designing, analyzing, and controlling pharmaceutical manufacturing processes by monitoring parameters that impact quality – to ultimately minimize public health risks. Dr. Neubauer’s work orchestrates hardware, software, automation, mathematical models, and AI to discover optimal conditions for PAT end-to-end workflows. Integrating intelligent technologies and automation into PAT solutions is a key factor for moving the pharmaceutical industry toward optimized bioprocesses that improve safety and reduce hands-on intervention. The Agilent Thought Leader Award will support his ongoing research into understanding and optimizing bioprocesses for difficult-to-express proteins and the development of scale-up/scale-down strategies. “We are truly grateful and excited that Agilent's award will open up the opportunity to incorporate two-dimensional liquid chromatography and mass spectrometry into our upcoming bioprocess laboratory. The use of such leading-edge instrumentation is a fundamental element in our journey towards achieving a higher level in automated bioprocess development,” said Dr. Neubauer who established and heads the KIWI-biolab as an International Future Laboratory for AI for Intelligent Integrated Biolaboratories. “Given our recent progress in seamlessly orchestrating all devices required in the process, ranging from extensive analyte-specific sample preparation to the management of big data, we feel ready to conquer this next logical step of integration.” “Agilent is pleased to grant this Thought Leader Award to Dr. Neubauer to support his scientific developments in the biopharma space,” said Sudharshana Seshadri, vice president and general manager of Agilent’s Liquid Chromatography, Mass Spectrometry, and Automation Divisions, and executive sponsor of the award. “His important work will help the pharmaceutical industry optimize their bioprocesses and accelerate improved healthcare worldwide.” The Agilent Thought Leader Award program promotes fundamental scientific advances by contributing financial support, products, and expertise to the research of influential thought leaders in the life sciences, diagnostics, and chemical analysis space. To learn more, visit the Agilent Thought Leader Award website. About Agilent Technologies Agilent Technologies Inc. (NYSE: A) is a global leader in analytical and clinical laboratory technologies, delivering insights and innovation that help our customers bring great science to life. Agilent’s full range of solutions includes instruments, software, services, and expertise that provide trusted answers to our customers' most challenging questions. The company generated revenue of $6.85 billion in fiscal 2022 and employs 18,000 people worldwide. Information about Agilent is available at . To receive the latest Agilent news, please subscribe to the Agilent Newsroom. Follow Agilent on LinkedIn and Facebook.

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