Article
Author: Zafer, Dila ; Kubota, Tetsuo ; Kitase, Yuma ; Yoshino, Ai ; Onishi, Yosuke ; Hayashi, Sora ; Oba, Atsuko ; Kashima, Kohei ; Jones, Sora ; Shiohama, Tadashi ; Miyosawa, Yukihide ; Hayashi, Haru ; Hiroma, Takehiko ; Shiraki, Seiya ; Hayashi, Rin ; Koyabu, Yui ; Yamaide, Fumiya ; Ishikawa, Chie ; Fujii, Katsunori
Recent advances in neonatal care have improved survival rates of preterm infants but highlighted the persistent challenge of neurological impairments. This study focuses on delta wave analysis in neonatal electroencephalography (EEG) as a marker for brain maturation and injury. Using quantitative EEG methods, including spectral power analysis, we examined 399 EEG recordings from infants with gestational ages spanning 23-42 weeks. Results demonstrated significant maturation-related changes in delta wave spectral power across cortical regions, particularly in lower-frequency bands. Suppression of delta wave power correlated with visual assessments of brain injury severity. These findings suggest that delta wave spectral power analysis enhances the precision of brain function evaluation, providing a valuable complement to conventional methods such as amplitude-integrated EEG (aEEG). This approach holds potential for improving early diagnosis and guiding therapeutic interventions for neonatal brain injuries.