Zhengzhou Tongtai Pharmaceutical Technology Co., Ltd.

To evaluate the time-dependent blood concentrations of the main ingredient triflusal and the main metabolite HTB after single or multiple oral administration of triflusal capsules to healthy volunteers after meals, calculate the main pharmacokinetic parameters, understand the absorption, distribution, and elimination patterns of triflusal in the human body, and provide experimental basis for the formulation of clinical trial plans.

To observe the in vivo time course of single-dose oral administration of triflusal tablets and reference preparation triflusal capsules in healthy adult males after fasting or crossover after eating, evaluate the relative bioavailability, determine whether they are bioequivalent, and guide clinical drug use.

To evaluate the efficacy and safety of triflusalgia capsules in the treatment and prevention of cerebral infarction using enteric-coated aspirin tablets as control.