A randomised controlled trial investigating the incidence of short-term complications between high- versus low-position of umbilical catheters in neonates.

Start Date01 May 2024

Sponsor / Collaborator

Hospital Universiti Sains Malaysia

NCT06389617 / Not yet recruitingNot Applicable

Different Doses of Intravenous Administered Dexamethasone Effecting Brachial Plexus Supraclavicular Block for Creation of Arteriovenous Fistula in End Stage Renal Disease: A Randomized Controlled Trial

To compare the analgesic properties of ultrasound guided supraclavicular block using ropivacaine 0.5% in arteriovenous fistula creation when used in combination with intravenous administered dexamethasone at 4mg and 8 mg as an adjuvant

Start Date01 May 2024

Sponsor / Collaborator

Hospital Universiti Sains Malaysia

NCT06235827 / RecruitingNot ApplicableIIT

Effects of Green Tea Consumption on Retinal Nerve Fiber Layer ( RNFL) and Intraocular Pressure ( IOP) in Patients With Primary Glaucoma

The goal of this randomised control trial is to learn about the effect of green tea consumption on patients with primary glaucoma.
The main questions to answer are:
Is there any difference of intraocular pressure (IOP) in patient with primary glaucoma after 1 month, 3 months and 6 months who is consuming green tea compared to patient not consuming green tea?
Is there any difference of retina nerve fibre layer in patient with primary glaucoma after 1 month, 3months and 6 months who is consuming green tea compared to patient not consuming green tea?
Researchers will compare patients with primary glaucoma who are consuming green tea and normal daily drinking to see if any affect to intraocular pressure and retina nerve fibre layer.

Start Date01 Feb 2024

Sponsor / Collaborator

Universiti Sains Malaysia

[+1]

100 Clinical Results associated with Hospital Universiti Sains Malaysia

0 Patents (Medical) associated with Hospital Universiti Sains Malaysia

774

Literatures (Medical) associated with Hospital Universiti Sains Malaysia

31 Dec 2024·Health Psychology and Behavioral Medicine

A survey exploring the nexus of psychological traits, nature connection, and quality of life among patients with rheumatoid arthritis

Article

Author: Eng Hui, Ellern ; Ching, Siew Mooi ; Wu, Shin Ling ; Ooi, Pei Boon ; Peh, Suat Cheng ; Hwang, Jung Shan ; Chow, Sook Khuan ; Wan Ghazali, Wan Syamimee ; Teh, Jane Kimm Lii

BackgroundAs the recognition of psychological factors in chronic illness management grows, this study examined the interplay of psychological traits - grit, self-efficacy, resilience, and nature-relatedness - and their collective impact on the Quality of Life (QoL) among patients with rheumatoid arthritis (RA) in Malaysia.MethodsA cross-sectional study was conducted among 222 patients with RA at a private hospital in Malaysia. Utilizing validated scales, including the Connor-Davidson Resilience Scale, Short Grit Scale, Nature Relatedness Scale, and Arthritis Self Efficacy Scale, data were collected. Pearson Product-moment Correlation analyses assessed the relationships between variables, and a multiple mediation analysis explored the mediating effects of resilience, grit, and self-efficacy on the relationship between nature-relatedness and QoL.FindingsOf the 222 participants (86% female, mean age = 56.03, S.D. = 13.42), the analysis revealed a significant mediating role of resilience in the relationship between nature-relatedness and QoL among RA patients (b = -.117, SE = .042, 95% BCa CI [-.208, -.046]). Although grit and self-efficacy positively correlated with QoL, they did not serve as significant mediators in the nature-relatedness - QoL relationship. This highlights the pivotal role of building a sense of resiliency among patients with RA.InterpretationIndividuals with RA are not only resilient in terms of their psychological traits such as grit, self-efficacy, and general resilience but also exhibit resilience in their connection and interaction with the natural environment (nature-relatedness). This holistic concept recognizes that fostering resilience in both psychological aspects and the context of one's environment is crucial for promoting overall well-being, particularly in the management of chronic illnesses like RA. It emphasizes the interconnectedness of psychological factors and environmental engagement in contributing to an individual's ability to cope and thrive despite health challenges.

01 Dec 2024·Endoscopy

Biliary ascariasis: extraction

Article

Author: Rahimi, Muhammad ; Voon Meng, Leow ; Yahya, Maya Mazuwin ; Mohammad Azmi, Mohd Azem Fathi ; Mohamad, Ikhwan Sani

01 Dec 2024·Analytical Biochemistry

Isolation and characterization of ssDNA aptamers against BipD antigen of Burkholderia pseudomallei

Article

Author: Ismail, Aziah ; Yunus, Muhammad Hafiznur ; Harun, Azian ; Fadzli Mustaffa, Khairul Mohd ; Najib, Mohamad Ahmad ; Aziah, Ismail ; Selvam, Kasturi ; Zainulabid, Ummu Afeera ; Wahab, Habibah A ; Khalid, Muhammad Fazli ; Wahab, Habibah A.

BACKGROUNDMelioidosis is difficult to diagnose due to its wide range of clinical symptoms. The culture method is time-consuming and less sensitive, emphasizing the importance of rapid and accurate diagnostic tests for melioidosis. Burkholderia invasion protein D (BipD) of Burkholderia pseudomallei is a potential diagnostic biomarker. This study aimed to isolate and characterize single-stranded DNA aptamers that specifically target BipD.METHODSThe recombinant BipD protein was produced, followed by isolation of BipD-specific aptamers using Systematic Evolution of Ligands by EXponential enrichment. The binding affinity and specificity of the selected aptamers were evaluated using Enzyme-Linked Oligonucleotide Assay.RESULTSThe fifth SELEX cycle showed a notable enrichment of recombinant BipD protein-specific aptamers. Sequencing analysis identified two clusters with a total of seventeen distinct aptamers. AptBipD1, AptBipD13, and AptBipD50 were chosen based on their frequency. Among them, AptBipD1 exhibited the highest binding affinity with a K_d value of 1.0 μM for the recombinant BipD protein. Furthermore, AptBipD1 showed significant specificity for B. pseudomallei compared to other tested bacteria.CONCLUSIONAptBipD1 is a promising candidate for further development of reliable, affordable, and efficient point-of-care diagnostic tests for melioidosis.

100 Deals associated with Hospital Universiti Sains Malaysia

100 Translational Medicine associated with Hospital Universiti Sains Malaysia

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