Immune-mediated bowel diseases (IMBD), notably ulcerative colitis and Crohn's disease, impose a
substantial global health burden due to their intricate etiology and escalating prevalence. The nexus between intestinal
parasites and the gut microbiome in IMBD is a dynamic and complex field of study. Several studies
have evidenced the capacity of intestinal parasites to modulate the gut microbiome, inducing alterations in microbial
diversity, abundance, and metabolic activity. These changes are crucial in influencing the immune response
and contributing to the development of IMBDs. Simultaneously, the gut microbiome functions as a
linchpin in sustaining intestinal homeostasis and immune regulation. Dysbiosis, marked by shifts in gut microbial
composition, is intricately linked to IMBD pathogenesis. Imbalances in the gut microbiota contribute to
hallmark features of IMBDs, such as heightened gut permeability, chronic inflammation, and aberrant immune
responses. The bidirectional interaction between intestinal parasites and the gut microbiome adds a layer of
complexity to understanding IMBDs. Specific parasites, including hookworms and Necator americanus, exhibit
immune downregulation and potential therapeutic applications in celiac disease. Conversely, infections with
Strongyloides stercoralis and Blastocystis mirror IBD symptoms, underscoring the intricate relationship between
parasites and disease pathogenesis. Further investigation is imperative to comprehensively unravel the
mechanisms linking intestinal parasites and the gut microbiome in IMBD. This understanding holds the potential
to pave the way for targeted therapeutic strategies aiming to restore gut microbiota homeostasis and alleviate
the debilitating symptoms of these conditions. Harnessing the intricate interplay among parasites, the gut
microbiome, and the host immune system may unveil novel approaches for managing and treating IMBDs.