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MechanismRIPK1 inhibitors |
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Drug Highest PhasePhase 1/2 |
First Approval Ctry. / Loc.- |
First Approval Date- |
A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study to Assess Safety and Efficacy of SIR1-365 in Patients With Severe COVID-19
Primary Objective:
• To evaluate overall safety and tolerability of SIR1-365 in patients with severe COVID-19
Secondary Objectives:
To assess the clinical efficacy of SIR1-365 in patients with severe COVID-19
To assess the effects of SIR1-365 on multiple inflammatory biomarker levels including C-reactive protein (CRP), ferritin, lymphocyte and neutrophil counts, cytokines, and chemokines
To assess the effects of SIR1-365 on biomarkers indicative of target engagement in patients with severe COVID-19
To assess the effects of SIR1-365 on biomarkers indicative of kidney injury in patients with severe COVID-19
To assess the effects of SIR1-365 on biomarkers indicative of cardiovascular endothelial cell damage in patients with severe COVID-19
To characterize plasma pharmacokinetics (PK) of SIR1-365 in patients with severe COVID-19
100 Clinical Results associated with Sironax USA, Inc.
0 Patents (Medical) associated with Sironax USA, Inc.
100 Deals associated with Sironax USA, Inc.
100 Translational Medicine associated with Sironax USA, Inc.