Altheia Science Srl

SEATTLE, MILAN, July 28, 2022 (GLOBE NEWSWIRE) -- AGC Biologics, a leading global Biopharmaceutical Contract Development and Manufacturing Organization (CDMO), today announced a new partnership with Altheia Science, a gene therapy company pioneering cell and gene therapy strategies to treat autoimmune diseases and cancer. Through this partnership, Altheia Science will advance its development of autoimmunity treatments, focused on modulating PD-L1 expression in patients’ hematopoietic stem and progenitor cells, into clinical testing. AGC Biologics is performing drug product development at its Milan facility using lentiviral vector (LVV) and autologous CD34+ hematopoietic stem and progenitor cell systems. The cells will be transduced using a highly efficient ex vivo lentiviral material to encode the human PD-L1 DNA. “The AGC Biologics Milan site has a long-standing expertise in successfully developing stem cell-based gene therapies, from clinical testing up to commercialization,” said Paolo Rizzardi, Chief Executive Officer of Altheia Science. “We believe this partnership is key in supporting our gene therapy programs and making these innovative therapies available to patients." The AGC Biologics Milan facility has one of the strongest development and manufacturing track records in the global cell and gene industry, working with virtually any cell type and lentiviral, retroviral and adeno‐associated viral vectors. The site has 25 years of expertise, including manufacturing three commercial products, and teams of scientists with significant development and regulatory experience. The site was the first ex-vivo cell and gene therapy site approved in Europe for GMP manufacturing of clinical and commercial supplies. “We are pleased Altheia Science placed their trust in our cell therapy and viral vector services, and our Milan site, at this important stage in their product’s lifecycle,” notes JB Agnus, Chief Business Officer of AGC Biologics. “Our global Cell Therapy and Viral Vector services are powerful tools for partners creating life-changing treatments for patients. We pride ourselves on our ability to collaborate with cell and gene developers and work within their unique specifications and requirements.” AGC Biologics’ cell therapy services and viral vector capabilities leverage the latest technology and processes, including proprietary platforms developed to address the evolving advanced therapies industry. To learn more about the company and its complete list of biologics and cell and gene services, visit . About Altheia Science Altheia Science has been founded by Prof. Alessandra Biffi, MD, and Prof. Paolo Fiorina, MD, Ph.D., together with the investment company AurorA-TT ( ). Altheia Science develops pioneering cell & gene therapy strategies to treat autoimmune diseases and cancer. To learn more, visit . About AGC Biologics AGC Biologics is a leading global biopharmaceutical Contract Development and Manufacturing Organization (CDMO) with a strong commitment to delivering the highest standard of service as we work side-by-side with our clients and partners every step of the way. We provide world-class development and manufacture of mammalian and microbial-based therapeutic proteins, plasmid DNA (pDNA), messenger RNA (mRNA), viral vectors, and genetically engineered cells. Our global network spans the U.S., Europe, and Asia, with cGMP-compliant facilities in Seattle, Washington; Boulder and Longmont, Colorado; Copenhagen, Denmark; Heidelberg, Germany; Milan, Italy; and Chiba, Japan and we currently employ more than 2,500 employees worldwide. Our commitment to continuous innovation fosters the technical creativity to solve our clients’ most complex challenges, including specialization in fast-track projects and rare diseases. To learn more, visit  . Attachment AGC Biologics Signs Contract with Altheia Science Nick McDonald AGC Biologics 4254193555 nmcdonald@agc.com

Dublin, Feb. 15, 2021 (GLOBE NEWSWIRE) -- The "Gene Therapy Market by Therapeutic Approach, Type of Gene Therapy, Type of Vectors Used, Therapeutic Areas, Route of Administration, and Key Geographical Regions: Industry Trends and Global Forecasts, 2020-2030" report has been added to ResearchAndMarkets.com's offering. Over time, several gene therapies have been developed for the treatment of both simple and complex genetic disorders. In fact, there are 10 approved gene therapies (recent examples include Zolgensma, ZyntegloT and Collategene) to date, and more than a thousand product candidates being evaluated in clinical trials, worldwide. Considering the current pace of research and product development activity in this field, experts believe that the number of clinical research initiatives involving gene therapies are likely to grow by 17% annually. In this context, the USFDA released a notification, mentioning that it now expects to receive twice as many gene therapy applications each year, starting 2020. Despite the ongoing pandemic, it is worth highlighting that gene therapy companies raised approximately USD 5.5 billion in capital investments, in 2020 alone. This is indicative of the promising therapeutic potential of this emerging class of pharmacological interventions, which has led investors to bet heavily on the success of different gene therapy candidates in the long term. Several technology platforms are currently available for discovery and development of various types of gene therapies. In fact, advances in bioanalytical methods and genome editing and manipulation technologies, have enabled the development of novel therapy development tools/platforms. In fact, technology licensing is a lucrative source of income for stakeholders in this industry, particularly for those with proprietary gene editing platforms. Given the growing demand for interventions that focus on the amelioration of the underlying (genetic) causes of diseases, it is expected that the gene therapy pipeline will continue to steadily expand. Moreover, promising results from ongoing clinical research initiatives are likely to bring in more investments to support therapy product development initiatives in this domain. Therefore, we are led to believe that the global gene therapy market is poised to witness significant growth in the foreseen future. The report features an extensive study of the current market landscape of gene therapies, primarily focusing on gene augmentation-based therapies, oncolytic viral therapies, immunotherapies and gene editing therapies. The study also features an elaborate discussion on the future potential of this evolving market. Key Questions Answered Who are the leading industry players engaged in the development of gene therapies? How many gene therapy candidates are present in the current development pipeline? Which key disease indications are targeted by such products? Which types of vectors are most commonly used for effective delivery of gene therapies? What are the key regulatory requirements for gene therapy approval, across various geographies? Which commercialization strategies are most commonly adopted by gene therapy developers, across different stages of development? What are the different pricing models and reimbursement strategies currently being adopted for gene therapies? What are the various technology platforms that are either available in the market or are being designed for the development of gene therapies? Who are the key CMOs/CDMOs engaged in supplying viral/plasmid vectors for gene therapy development? What are the key value drivers of the merger and acquisition activity in the gene therapy industry? Who are the key stakeholders that have actively made investments in the gene therapy domain? Which are the most active trial sites related to this domain? How is the current and future market opportunity likely to be distributed across key market segments? Key Topics Covered: 1. PREFACE 2. EXECUTIVE SUMMARY 3. INTRODUCTION 4. GENE DELIVERY VECTORS 5. REGULATORY LANDSCAPE AND REIMBURSEMENT SCENARIO 6. MARKET OVERVIEW 7. COMPETITIVE LANDSCAPE 8. MARKETED GENE THERAPIES 9. KEY COMMERCIALIZATION STRATEGIES 10. LATE STAGE GENE THERAPIES 11. EMERGING TECHNOLOGIES 12. KEY THERAPEUTICS AREAS 13. PATENT ANALYSIS 14. MERGERS AND ACQUISITIONS 15. FUNDING AND INVESTMENT ANALYSIS 16. CLINICAL TRIAL ANALYSIS 17. COST PRICE ANALYSIS 18. BIG PHARMA PLAYERS: ANALYSIS OF GENE THERAPY RELATED INITIATIVES 19. DEMAND ANALYSIS 20. MARKET FORECAST AND OPPORTUNITY ANALYSIS 21. VECTOR MANUFACTURING 22. CASE STUDY: GENE THERAPY SUPPLY CHAIN 23. CONCLUSION A Selection of Companies Mentioned Include: 4BIO Capital 4D Molecular Therapeutics AavantiBio aaVective AAVogen AbbVie Allergan AlphaVax Altheia Science Amgen Amplo Angionetics ApolloBio Arthrogen Astellas Pharma AstraZeneca Atlas Venture Atsena Therapeutics AVROBIO Baillie Gifford Baldota Group Bayer Biogen BridgeBio Bristol-Myers Squibb Calimmune Cardiogen Sciences Casdin Capital Codexis CSL Behring Editas Medicine Fundacion Sanfilippo B Google Ventures Gradalis Green Cross Holdings GSK Handl Therapeutics Hovione Scientia Intrexon Invus IVERIC bio Janssen Pharmaceuticals Johnson & Johnson Development Juda Capital K2 Venture Capital Lacerta Therapeutics MeiraGTx Merck MERITZ Securities Mitsubishi Tanabe Pharma MultiVir Myonexus Therapeutics Navega Therapeutics NeoMed Nerveda Omega Funds Omnes Capital OrbiMed ORI Capital Otonomy Oxford BioMedica Oxular REGENXBIO Renova Therapeutics Roche Sanofi StrideBio Surveyor Capital Syncona Synpromics T. Rowe Price Takeda Pharmaceutical Targovax Temasek Tenaya Therapeutics TheraBiologics Theravectys Tocagen WuXi AppTec XyloCor Therapeutics Ysios Capital Ziopharm Oncology For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. CONTACT: ResearchAndMarkets.com Laura Wood, Senior Press Manager press@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470 For U.S./CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900