Delving into the Latest Updates on Dashi Pharmaceutical (Guangdong) Co., Ltd. with Synapse

Overview

Tags

Neoplasms

Nervous System Diseases

Bispecific antibody

Monoclonal antibody

Antibody drug conjugate (ADC)

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	6
Nervous System Diseases	1

Top 5 Drug Type	Count

Bispecific antibody	3
Monoclonal antibody	2
Antibody drug conjugate (ADC)	1

Top 5 Target	Count

Trop-2(Tumor-associated calcium signal transducer 2)	1
HER2 x PDL1	1
CD276 x PDL1	1
NGF(Nerve growth factor)	1
CD47(Cluster of differentiation 47)	1

Primary objective: To evaluate the safety and tolerability of DS002 injection in the treatment of bone metastasis pain. Secondary objectives: To evaluate the preliminary efficacy of DS002 injection in the treatment of moderate to severe bone metastasis pain; To evaluate the immunogenicity of DS002 in patients; To evaluate the pharmacokinetic (PK) characteristics of DS002 in subjects.

Start Date28 Sep 2022

Sponsor / Collaborator

Dashi Pharmaceutical (Guangdong) Co., Ltd.

CTR20210155 / CompletedPhase 1

一项评价DS002注射液单次给药在健康受试者中的安全性、耐受性、药代动力学及免疫原性的随机、双盲、剂量递增、安慰剂对照的I期临床研究

[Translation] A randomized, double-blind, dose-escalation, placebo-controlled Phase I clinical study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of a single dose of DS002 injection in healthy subjects

主要目的是评价DS002在健康受试者中单次给药的安全性和耐受性，同时评价DS002在健康受试者中单次给药后的药代动力学（Pharmacokinetics, PK）特征和评价DS002在健康受试者中单次给药后的免疫原性，为后续试验推荐给药剂量。

[Translation]

The main objectives are to evaluate the safety and tolerability of a single dose of DS002 in healthy subjects, to evaluate the pharmacokinetic (PK) characteristics of DS002 after a single dose in healthy subjects, and to evaluate the immunogenicity of DS002 after a single dose in healthy subjects, so as to recommend a dosage for subsequent trials.

Start Date22 Feb 2021

Sponsor / Collaborator

Dashi Pharmaceutical (Guangdong) Co., Ltd.

100 Clinical Results associated with Dashi Pharmaceutical (Guangdong) Co., Ltd.

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0 Patents (Medical) associated with Dashi Pharmaceutical (Guangdong) Co., Ltd.

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100 Deals associated with Dashi Pharmaceutical (Guangdong) Co., Ltd.

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100 Translational Medicine associated with Dashi Pharmaceutical (Guangdong) Co., Ltd.

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Pipeline

Pipeline Snapshot as of 24 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

3

2

Preclinical

IND Approval

2

1

Phase 2 Clinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

DS-002 ( NGF )	Cancer Pain More	Phase 2 Clinical
DS003(Tashi Pharmaceutical) ( CD47 )	Neoplasms More	IND Approval
DS001	Advanced cancer More	IND Approval
HER2/PD-L1 BsAb (Dartsbio Pharmaceuticals) ( HER2 x PDL1 )	Neoplasms More	Preclinical
DS-005	Neoplasms More	Preclinical