Delving into the Latest Updates on Shandong Bausch & Lomb Freda Pharmaceutical Co. Ltd. with Synapse

Overview

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Eye Diseases

Immune System Diseases

Nervous System Diseases

Small molecule drug

Polymer

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Immune System Diseases	2
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	2
Polymer	1

Top 5 Target	Count

H1 receptor(Histamine H1 receptor)	1
nAChRα1/β1/δ/γ(Acetylcholine receptor; alpha1/beta1/delta/gamma)	1

The efficacy of disinfectants to be used in manufacturing environment of medical industry against selected microorganisms on representative surface was evaluated and demonstrated.Efficacy of the disinfectants on representative surface would be evaluated by measuring the mean surviving populations of test microorganisms after exposed to test disinfectants on the surface of a coupon representing a surface present in the manufacturing environment of medical industry.70% Iso-Pr alc. could work against bacteria, 1:32 Spore-klenz could work against bacteria and mold.The effectiveness of disinfectants to different coupons and microorganisms can be not the same.We should choose the proper disinfectants in the manufacturing environments of medical industry.

Yaoxue Shijian Zazhi

Carbazole method for simultaneous determination of sodium hyaluronate and chondroitin sulfate

Author: Bai, Ruo-wan ; Jiang, Wen ; Wan, Xiu-yu ; Zhang, Tian-min

To establish a carbazole method for the simultaneous determination of sodium hyaluronate (SH) and chondroitin sulfate (CS).By regulating acidity or alkalinity and ionic strength with sodium acetate, CS was selectively precipitated with cetylpyridinium chloride (CPC), whereas SH was not, so SH and CS were separatedThe sample pretreatment conditions were as follows: measuring 10 mL mixture of SH and CS accurately, adding 1.6 g sodium acetate and 10 mL CPC of 12.5 mmol/L, standing for 1 h after stirring thoroughly, then, the solution was filtered with 20 μm filter membrane and the filtrate was used to determine the content of SH, the precipitates on the filter membrane were resolved with 1.4 mol/L NaCl solution by ultrasonic treatment for the determination of CS.The average recoveries of SH and CS were 101.2% and 99.4% with RSD of 1.05% and 0.96%, resp.This method can be used for the simultaneous determination of SH and CS without interference with each other.

Shipin Yu Yaopin

Determination of Naphazoline Hydrochloride and Chlorpheniramine Maleate in Naiminjixin Eye Drops by HPLC

Author: Zhu, Jiandong ; Bai, Ruowan ; Pan, Jifei ; Li, Yongchun ; Yan, Guodong

An HPLC method for simultaneous determination of Naphazoline Hydrochloride (Naph) and Chlorpheniramine Maleate (Chlor) as well as determination of their related substances in Naiminjixin Eye Drops was established.A C₁₈ column was used and the mobile phase consisted of sodium heptanesulfonate solution-methanol (60:40).The detection wavelength was 230 nm.The peak area response vs. concentration for Naph was linear over the range of 5.80-58.00 μg/mL (r = 0.999 9, n = 5).The limit of detection (LOD) was 0.20 ng.The average recovery was 99.79% with RSD of 0.23%.The peak area response vs. concentration for Chlor was linear over the range of 10.60-212.00 μg/mL (r = 0.999 9, n = 5) and the LOD was 0.72 ng.The average recovery was 99.95% with RSD of 0.65%.This method is accurate and precise, and can be used for the determinations of Naph, Chlor and their related substances in Naiminjixin Eye Drops.

100 Deals associated with Shandong Bausch & Lomb Freda Pharmaceutical Co. Ltd.

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100 Translational Medicine associated with Shandong Bausch & Lomb Freda Pharmaceutical Co. Ltd.

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Pipeline

Pipeline Snapshot as of 01 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Approved

3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Pheniramine Maleate ( H1 receptor )	Hypersensitivity More	Approved
Carbachol ( nAChRα1/β1/δ/γ )	Ocular Hypertension More	Approved
Sodium Hyaluronate	Osteoarthritis, Knee More	Approved