Laparoscopic Versus Robot-assisted Left-sided Pancreatectomy for Benign and Pre-malignant Lesions (DIPLOMA-3): an International Multicenter Patient-blinded Randomized Controlled Trial

The DIPLOMA-3 trial is an international, multicenter, patient-blinded randomized controlled trial comparing laparoscopic and robot-assisted left-sided pancreatectomy. Patients with an indication for elective left-sided pancreatecomy for benign or premalignant lesions in the body or tail of the pancreas and considered eligible will be randomized between laparoscopic and robot-assisted resection.

Start Date01 Jun 2025

Sponsor / Collaborator

Catharina Ziekenhuis

[+3]

NL-OMON56982

/ RecruitingNot Applicable

The 10-year follow-up of the Delta-TT trial: Stability of the Delta-TT cup with Polyethylene insert compared to the Delta-TT cup with Ceramic insert. - RSA-10

Start Date14 Nov 2024

Sponsor / Collaborator

Onze Lieve Vrouwe Gasthuis

NL-OMON56622

/ RecruitingNot Applicable

Reducing Pain and Anxiety with Virtual Reality at the Emergency department, in children - REPAVE-C

Start Date08 Nov 2024

Sponsor / Collaborator

Onze Lieve Vrouwe Gasthuis

100 Clinical Results associated with Onze Lieve Vrouwe Gasthuis

0 Patents (Medical) associated with Onze Lieve Vrouwe Gasthuis

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Literatures (Medical) associated with Onze Lieve Vrouwe Gasthuis

01 Apr 2025·Developmental Cognitive Neuroscience

Maternal depressive symptoms in childhood and offspring brain cortical and subcortical volumetric change: A repeated imaging study from age 4–10 years

Article

Author: Tan, Ai Peng ; Koyama, Yuna ; Setoh, Peipei ; Tiemeier, Henning ; Broekman, Birit ; Chen, Helen ; Sadikova, Ekaterina ; Zhou, Juan Helen ; Gluckman, Peter

Maternal depressive symptoms have been associated with offspring's brain structural differences. However, previous studies were limited by cross-sectional designs, brain region-of-interest analyses, or clinical samples. Importantly, few studies assessed the early childhood brain. This study analyzed data from a Singaporean cohort of 217 children with 589 repeated structural neuroimaging from 4.5 to 10.5 years (2-4 assessments) in relation to maternal depressive symptoms. Maternal depressive symptoms were measured by questionnaire at child age 4.5 years. Mixed models explored within-sample change accounting for non-linear brain development. Multiple testing was corrected, and a stringent threshold was applied. Maternal depressive symptoms were associated with persistently smaller precentral gyral volume over time (β = -0.162 [-0.238; -0.086], p_adj < 0.001). In analysis with time interaction, maternal symptoms were associated with curvilinear changes in the volumes of supramarginal (β = -0.019 [-0.027; -0.010], p_adj < 0.001) and precuneus gyrus (β = -0.016 [-0.025; -0.007], p_adj = 0.007); this suggests delayed volumetric development in brain areas governing attention, memory, and language among children exposed to severe maternal symptoms. The findings implicate that childhood maternal depressive symptoms are associated with persistent differences in precentral volume and affect the brain volumetric development of complex sensory information processing regions, rather than in emotion regulation areas implicated in the depression experience. Our findings emphasize repeated childhood imaging to understand child brain development risk factors.

01 Apr 2025·Mycopathologia

Publisher Correction: Iron Levels in Bronchoalveolar Lavage Fluid of Hematological Patients with Suspected Invasive Pulmonary Aspergillosis and their Association with 12‑week Mortality: A Retrospective Cohort Study

Author: Wagemakers, A ; Lamberink, H ; van Dijk, K ; Heijmans, J

01 Apr 2025·Netherlands Heart Journal

Impact of lesion preparation and stent optimisation on lesion-oriented events in PCI with drug-eluting stents: 5-year results from the AIDA trial

Article

Author: van der Schaaf, Rene J ; Tijssen, Jan G P ; Arkenbout, Karin E K ; Koch, Karel T ; Grundeken, Maik J D ; de Winter, Robbert J ; Hofma, Sjoerd H ; Kalkman, Deborah N ; Tijssen, Ruben Y G ; Renkens, Mick P L ; Weevers, Auke P J D ; Wykrzykowska, Joanna J ; Serruys, Patrick W ; Kerkmeijer, Laura S M ; Kraak, Robin P ; Onuma, Yoshinobu

AbstractBackgroundMeticulous implantation strategies (i.e. lesion predilatation, stent sizing and postdilatation) are known to decrease lesion-oriented adverse events (LOCE) following percutaneous coronary intervention (PCI) with bioresorbable scaffolds. Their impact on PCI with drug-eluting stents remains unclear.ObjectiveTo assess the impact of meticulous implantation strategies on long-term LOCE in PCI with everolimus-eluting stents (EES).MethodsThis substudy of the AIDA trial (NCT01858077) focused on the evaluation of predilatation, stent sizing and postdilatation through analyses of vessel and device diameters at various locations around the lesion. Their interrelations were assessed using quantitative coronary angiography across various lesion locations. Logistic regression was used to evaluate how predictors influenced the primary outcome LOCE, which includes target lesion revascularisation (TLR), target-vessel myocardial infarction (TV-MI) and definite stent thrombosis (ST).ResultsLOCE occurred in 84 (7.7%) of 1098 lesions, mainly driven by TLR (63, 5.7%) and TV-MI (46, 4.2%), with ST occurring in 9 (0.8%) lesions. Predilatation and postdilatation were performed in 92 and 49% of lesions, respectively. The difference between the diameter of the predilatation balloon and the reference vessel diameter was significantly associated with an increased risk for LOCE (odds ratio 4.84, 95% confidence interval: 1.91–12.7) with significant interaction with diabetes (p for interaction = 0.04), thus disfavouring predilatation with oversized balloons.ConclusionThe low LOCE rate (7.7%) over 5 years underscores the efficacy of PCI with EES. The use of ‘oversized’ balloons for predilatation was associated with an increased risk of LOCE by up to fivefold, a risk that was interestingly reduced in patients with diabetes mellitus.

100 Deals associated with Onze Lieve Vrouwe Gasthuis

100 Translational Medicine associated with Onze Lieve Vrouwe Gasthuis

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