Delving into the Latest Updates on Tibet Cheezheng Tibetan Medicine Co., Ltd. with Synapse

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Disease Domain	Count

Nervous System Diseases	2
Hemic and Lymphatic Diseases	1
Infectious Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Herbal medicine	6
Small molecule drug	1

Top 5 Target	Count

TrxR1(thioredoxin reductase 1)	1

以普通感冒24h解热率为主要疗效指标，与原剂型催汤丸以及安慰剂对照，在Ⅱb期临床试验基础上，进一步评价催汤丸工艺改进及改变剂型后，催汤颗粒治疗普通感冒的有效性与安全性，最终为药物注册申请获得批准提供充分依据。

[Translation]

Taking the 24-hour antipyretic rate of the common cold as the main efficacy indicator, compared with the original dosage form of Cuitang Pills and placebo, on the basis of the Phase IIb clinical trial, the effectiveness and safety of Cuitang Granules in treating the common cold were further evaluated after the process improvement and dosage form change of Cuitang Pills, ultimately providing sufficient basis for the approval of the drug registration application.

Start Date20 Dec 2018

Sponsor / Collaborator

Tibet Cheezheng Tibetan Medicine Co., Ltd.

100 Clinical Results associated with Tibet Cheezheng Tibetan Medicine Co., Ltd.

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0 Patents (Medical) associated with Tibet Cheezheng Tibetan Medicine Co., Ltd.

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18

Literatures (Medical) associated with Tibet Cheezheng Tibetan Medicine Co., Ltd.

01 Jan 2024·Journal of Separation Science

Simultaneously characterization of multiple constituents in Valeriana jatamansi Jones using an online supercritical fluid extraction‐high‐performance liquid chromatography/supercritical fluid chromatography‐mass spectrometry system

Article

Author: Ren, Biao ; Chen, Haochang ; Dong, Jing ; Niu, Yaru ; Zhang, Xiaotian

Valeriana jatamansi Jones is a commonly used traditional Chinese medicine, boasting rich effective compositions with versatile chemical structures and wide polarity, including iridoids, chlorogenic acid, and flavonoids. Previous reports indicate that conventional high‐performance liquid chromatography (HPLC) analytical methods have proven inefficient performance in comprehensively characterizing components in Valeriana jatamansi. In the present study, a hybrid online analytical platform combining supercritical fluid extraction with both conventional HPLC separation (reverse phase) and supercritical fluid chromatography (normal phase) has been established and validated. This system can provide online extraction with two different chromatographic separation modes to increase separation ability and has been connected to a mass spectrometer to acquire high‐resolution mass spectrometry data. Then, the online platform was applied to screening components in Valeriana jatamansi. A total of 117 compounds were identified, including five lignans, 18 organic acids, six flavonoids, and 88 iridoids. Thirty‐three compounds were reported from Valeriana jatamansi for the first time. These results enrich our understanding of the components of Valeriana jatamansi and prove that the developed online platform in this study is a robust approach for accelerating working efficiency in comprehensively analyzing complicated samples.

01 Jan 2023·Journal of Ethnopharmacology

Anti-inflammatory and osteoprotective effects of Shi-Wei-Ru-Xiang pills on collagen-induced arthritis in rats via inhibiting MAPK and STAT3 pathways

Article

Author: Chen, Lunju ; Meng, Fengping ; Chen, Weiwu ; Tian, Juan ; Ju, Yankun ; Xiong, Hui ; Luo, Miao ; Mei, Zhinan

ETHNOPHARMACOLOGICAL RELEVANCEShi-Wei-Ru-Xiang pills (SW) as a tradition Tibetan medicine has been clinically proved effective in rheumatoid arthritis (RA) treatment. However, the underlying mechanism of SW remains unclear.AIM OF THE STUDYThis study aimed to investigate the anti-arthritic effect of SW and its possible mechanisms of action.MATERIALS AND METHODSA CIA rat model in vivo, and IL-1β-stimulated synoviocytes or chondrocytes and a co-culture system (IL-1β-stimulated synoviocytes/chondrocytes) in vitro were used to evaluate the effects of SW on the treatment of RA. Arthritic score, paw swelling rate, hematoxylin-eosin (HE) staining, and Safranin-O-Fast green (S-O) staining were used to evaluate the anti-arthritic activity of SW in CIA rats. TUNEL assay or flow cytometry were performed to measure chondrocytes apoptosis in vivo and invitro. The effects of SW on the expression and production of pro-inflammatory cytokines were assessed by qRT-PCR and Elisa. The inhibitory effects of SW on the phosphorylation of p38, Erk1/2, and STAT3 were analyzed by Western blot.RESULTSSW treatment significantly alleviated paw swelling, severity of arthritic and cartilage destruction in CIA rats. Moreover, SW decreased the expression of mRNAs of proinflammatory cytokines including TNF-α, IL-1β and IL-6 in the synovium, suppressed the production of these pro-inflammatory cytokines in serum and hind paws, downregulated the protein expression of p-p38, p-Erk1/2 and p-STAT3, and protected the chondrocytes apoptosis in CIA rats. Consistent with the results in vivo, SW also inhibited the activation of MAPK and STAT3 pathways, suppressed the expression of pro-inflammatory cytokines in IL-1β-stimulated synoviocytes, and attenuated chondrocytes apoptosis in IL-1β-stimulated chondrocytes. In the co-culture system, SW pre-treatment in IL-1β-stimulated synoviocytes exhibited inhibition of chondrocytes apoptosis, which was associated with attenuation of inflammation in synoviocytes.CONCLUSIONThese results suggested that the underlying mechanisms by which SW exerts its anti-arthritis effect may be related to the reduction of proinflammatory cytokine levels, inhibition of p38, Erk1/2 and STAT3 phosphorylation, and attenuating of chondrocyte apoptosis.

01 Aug 2021·Biomedicine & Pharmacotherapy

Corrigendum to ‘Proteomic changes in the hippocampus and motor cortex in a rat model of cerebral palsy: Effects of topical treatment’ [Biomed. Pharmacother. 133 (2021) 110844]

Author: Wang, Tao ; Ge, Wei ; Dou, Wanchen ; Zhang, Yusheng ; Ma, Chao ; Chen, Weiwu ; Xue, Qiao ; Tao, Jin

100 Deals associated with Tibet Cheezheng Tibetan Medicine Co., Ltd.

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100 Translational Medicine associated with Tibet Cheezheng Tibetan Medicine Co., Ltd.

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

1

2

Phase 2 Clinical

Phase 3 Clinical

1

3

Approved

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

QingPeng	Pain More	Approved
XiaoTong	Hyperostosis More	Approved
Honghuaruyi Pill	Vaginitis More	Approved
Cuitang Granules	Influenza, Human More	Phase 3
Xiaotong Aerosol	Soft Tissue Injuries More	Phase 2