Epilobium angustifolium L., known as fireweed, is a spontaneous perennial herb.Aerial parts of fireweed contain flavonoids, phenolic acids and ellagitannins.Thanks to this rich phytocomplex it is traditionally used in infusions and food supplements for prostatic ailments.Due to population ageing in Western countries, this market segment is increasing every year, however most of the products are based on phytosterols obtained from exotic plants.Therefore, the aim of this work was to cultivate, for the first-time, fireweed setting the best sustainable on-farm practices to respect the agro-environment, facilitate the entomophilous insects' health and to concentrate one of the most active polyphenols, oenothein B.Fireweed is then used for the production of the first high-value standardized extract