Last update 21 May 2026

SpringWorks Therapeutics Ireland Ltd.

Private Company|Ireland

Overview

Tags

Neoplasms
Other Diseases
Nervous System Diseases
Small molecule drug

Disease domain score
A glimpse into the focused therapeutic areas
Technology Platform
Most used technologies in drug development
Targets
Most frequently developed targets
Disease DomainCount
Neoplasms2
Endocrinology and Metabolic Disease2
Nervous System Diseases1
Hemic and Lymphatic Diseases1
Immune System Diseases1
Top 5 Drug TypeCount
Small molecule drug2
Top 5 TargetCount
γ-secretase(Gamma-secretase)1
MEK1 x MEK21

Related

2
Drugs associated with SpringWorks Therapeutics Ireland Ltd.
Mirdametinib
Target
MEK1 x MEK2
Mechanism
MEK1 inhibitors [+1]
Active Org.
Merck Europe BV [+4]
Originator Org.
Springworks Therapeutics, Inc.Springworks Therapeutics, Inc.
Active Indication
NF1 mutant Plexiform Neurofibroma [+16]
Inactive Indication
Advanced breast cancer [+5]
Drug Highest PhaseApproved
First Approval Ctry. / Loc.
United States
First Approval Date11 Feb 2025
Nirogacestat hydrobromide
Target
γ-secretase
Mechanism
γ-secretase inhibitors
Active Org.
GSK PlcGSK Plc [+5]
Originator Org.
Pfizer Inc.Pfizer Inc.
Active Indication
Fibroma [+6]
Inactive Indication
Adult Lymphoblastic Lymphoma [+8]
Drug Highest PhaseApproved
First Approval Ctry. / Loc.
United States
First Approval Date27 Nov 2023
100 Clinical Results associated with SpringWorks Therapeutics Ireland Ltd.
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0 Patents (Medical) associated with SpringWorks Therapeutics Ireland Ltd.
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100 Deals associated with SpringWorks Therapeutics Ireland Ltd.
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100 Translational Medicine associated with SpringWorks Therapeutics Ireland Ltd.
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Pipeline

Pipeline Snapshot as of 22 May 2026

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3
Approved
2
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Current Projects

Drug(Targets)IndicationsGlobal Highest Phase
Mirdametinib
 ( MEK1 x MEK2 )		NF1 mutant Plexiform Neurofibroma
More
Approved
Nirogacestat hydrobromide
 ( γ-secretase )		Aggressive Fibromatosis
More
NDA/BLA
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Translational Medicine

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Profit

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Grant & Funding(NIH)

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