SENORITA 1 trial showed laparoscopic sentinel lymph node biopsy and stomach preserving surgery in early gastric cancer can increase the quality of life. (Ryu KW et al. JCO 2022) The radioactive isotope is difficult to use because of the hazard of radiation and shortage of materials. The aim of this study is to investigate whether laparoscopic sentinel lymph node biopsy and stomach-preserving surgery using only fluorescence is feasible.

Start Date17 Aug 2023

Sponsor / Collaborator

National Cancer Center Korea

[+7]

KCT0002931

/ RecruitingNot Applicable

Immunological response and safety of autologous dendritic cells in triple-negative breast cancer (TNBC) patients who have received curative surgery after neoadjuvant chemotherapy(NCT).

Start Date28 Feb 2018

Sponsor / Collaborator

Dongnam Institute of Radiological & Medical Sciences

KCT0009315

/ CompletedNot Applicable

A study of autologous dendritic cells in triple-negative breast cancer patients who underwent Neoadjvant chemothrapy.

Start Date28 Feb 2018

Sponsor / Collaborator

Dongnam Institute of Radiological & Medical Sciences

100 Clinical Results associated with Dongnam Institute of Radiological & Medical Sciences

0 Patents (Medical) associated with Dongnam Institute of Radiological & Medical Sciences

575

Literatures (Medical) associated with Dongnam Institute of Radiological & Medical Sciences

01 Apr 2025·Journal of Immunotherapy

Comparison of Antitumor Effects of Combinations of Immune Checkpoint Inhibitors With Dendritic Cells Intratumorally Injected into Irradiated Mouse Adenocarcinoma

Article

Author: Song, Jin Hoo ; Son, Woo-Chang ; Kim, YoungHee ; Kim, Dong Won ; Kang, Hyun Bon ; Lee, Hong-Rae ; Park, You-Soo ; Park, Ga-Young ; Koh, Eun-Kyoung

Dendritic cells (DCs) are specialized immune cells that play a crucial role in presenting antigens and activating cytotoxic T lymphocytes to combat tumors. The immune checkpoint receptor programmed cell death-1 (PD-1) can bind to its ligand programmed cell death-ligand 1 (PD-L1), which is expressed on the surface of cancer cells. This interaction suppresses T-cell activation and promotes immune tolerance. Radiation therapy can increase the expression of PD-L1 on tumor cells, which can lead to a decrease in the effectiveness of the treatment, and detailed studies are needed to understand the mechanisms. As many patients develop resistance to chemotherapy and radiotherapy—either through lack of response or cancer recurrence—there is a critical need to maximize synergistic effects by selecting combination treatments that offer improved therapeutic efficacy with minimal side effects. In the present study, immature DCs (iDCs) were introduced directly into irradiated tumor sites (referred as IR/iDCs), and immune checkpoint blockades (ICBs) were administered intraperitoneally. We confirmed the antitumor effect of combining IR/iDCs and ICBs by examining tumor growth and mouse survival. The proportion of CD4+ and CD8+ T cells in splenocytes increased in the IR/iDCs-treated groups. Combining IR/iDCs with an anti-PD-L1 antibody led to a significant reduction in distant tumor growth and improved mouse survival rates compared with IR/iDCs alone or IR/iDCs + anti-PD-1 antibody. These findings suggest that integrating radiotherapy, DC-based immunotherapy, and ICB, specifically targeting PD-L1, may be an effective cancer treatment strategy.

04 Mar 2025·International Journal of Radiation Biology

Collaborative activities in a biological dosimetry network for radiation emergencies in South Korea

Article

Author: Yoon, Hyo Jin ; Kwon, Soon Woo ; Park, Seong-Hoon ; Lee, Yang Hee ; Kim, Hwa Young ; Seong, Ki Moon ; Oh, Su Jung ; Lee, Younghyun ; Jeong, Soo Kyung ; Yang, Su San

PURPOSEBiological dosimetry is an essential analytic method to estimate the absorbed radiation dose in the human body by measuring changes in biomolecules after radiation exposure. Joint response in a network to mass-casualty radiation incidents is one way to overcome the limitations of biological dosimetry, sharing the workload among laboratories. This study aimed to investigate the current performance, collaborative activities and technical advances of the Korea biodosimetry network (K-BioDos), and suggest the future directions toward successful joint response.MATERIALS AND METHODSA survey was performed to investigate the capacities of each laboratory and their expectations for the K-BioDos network. We summarized the capacities, expectations and technical advances of K-BioDos members. Based on the results, in-depth discussion was carried out to determine the future plan and activities of K-BioDos.RESULTSK-BioDos has grown to six laboratories since its establishment with three functional laboratories of biological dosimetry in South Korea. We constructed long-term strategy according the survey results, and performed various activities for enhanced biological dosimetry capabilities - including intercomparison exercises, education, and resource sharing. Through these active collaborations we achieved harmonization of biodosimetry protocols and technical improvement such as better image quality.CONCLUSIONSK-BioDos network performed various activities for joint response and constructed long-term plans, considering the expectations and feedbacks of members. K-BioDos continue to support members to establish and develop biodosimetry tools. These efforts and findings could serve as a fundamental guide for coordinated network responses in the event of large-scale radiological disaster.

01 Mar 2025·BMJ Open

Factors associated with health literacy in older adults aged 65 and over: a secondary data analysis of the 2021 Korea Health Panel applying the Andersen behavioural model

Article

Author: Moon, Chang Sun ; Kim, Yeong Eun ; Han, Ol

ObjectivesUsing the Korea Health Panel 2021 survey data, we identify factors associated with health literacy (HL) among older adults aged 65 years and older.DesignA secondary data analysis of the 2021 Korea Health Panel survey.SettingKorea Health Panel survey.ParticipantsData were from 3410 older adults ≧65 years of age, drawn from the 2016 registration census of the Korea Health Panel 2021 survey, with a stratified selection approach for participants.Outcome measureTo explore the factors associated with HL within the framework of the Andersen behavioural model, considering predisposing factors (age, gender, region and spouse), enabling factors (National Basic Livelihood Security recipient, education level, economic activity, usual source of care) and need factors (subjective health status, usual activities, depression/anxiety and chronic disease).AnalysisStepwise multiple regression analysis was employed to examine the factors associated with HL among the study participants within the framework of the Andersen behavioural model.ResultsStatistically significant associations with HL were found for predisposition factors (age, gender and residential area), enabling factors (National Basic Livelihood Security recipient, educational background and usual source of care) and need factors (subjective health status, usual activities and the presence of chronic diseases). While the National Basic Livelihood Security recipient was significant in model 2 (p=0.011), it became nonsignificant in model 3 after adding need factors (p=0.093). Adding enabling factors to model 1 significantly increased the explanatory power (ΔR2=0.084,p<0.001). Similarly, incorporating need factors into model 2 improved the model fit for model 3 (F=113.21,p<0.001) and significantly enhanced explanatory power (ΔR2=0.017,p<0.001).ConclusionsThis study highlights the importance of enabling factors, such as education level and usual source of care, and need factors, such as subjective health status and chronic disease management, in improving HL among older adults. Strategies addressing these factors could enhance HL and support healthy ageing by improving access to care and tailored health information.

100 Deals associated with Dongnam Institute of Radiological & Medical Sciences

100 Translational Medicine associated with Dongnam Institute of Radiological & Medical Sciences

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