Delving into the Latest Updates on PIN Pharma Inc. with Synapse

Overview

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Introduction

PIN Pharma is a privately owned business that specializes in research and development. The company's primary objective is to create immunotherapies that can treat a wide range of diseases, with an initial focus on oncology. The company employs a groundbreaking method to connect the innate and adaptive immune systems, which has the potential to revolutionize the field of medicine.

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Neoplasms

Recombinant polypeptide

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Disease Domain	Count

Neoplasms	1

Top 5 Drug Type	Count

Recombinant polypeptide	1

Understanding the impact of DNA methylation within different disease contexts often requires accurate assessment of these modifications in a genome-wide fashion. Frequently, patient-derived tissues stored in long-term hospital tissue banks have been preserved using formalin-fixation paraffin-embedding (FFPE). While these samples can comprise valuable resources for studying disease, the fixation process ultimately compromises the DNA's integrity and leads to degradation. Degraded DNA can complicate CpG methylome profiling using traditional techniques, particularly when performing methylation-sensitive restriction enzyme sequencing (MRE-seq), yielding high backgrounds and resulting in lowered library complexity. Here, we describe Capture MRE-seq, a new MRE-seq protocol tailored to preserving unmethylated CpG information when using samples with highly degraded DNA. The results using Capture MRE-seq correlate well (0.92) with traditional MRE-seq calls when profiling non-degraded samples, and can recover unmethylated regions in highly degraded samples when traditional MRE-seq fails, which we validate using bisulfite sequencing-based data (WGBS) as well as methylated DNA immunoprecipitation followed by sequencing (MeDIP-seq).

01 Jul 2022·iScience

Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer

Article

Author: Wei, Gonghong ; Ji, Boyao ; Wang, Ziwei ; Qu, Min ; Wang, Tao ; Lee, Hyung Joo ; Li, Daofeng ; Collins, Colin ; Huang, Jialiang ; Hong, Danni ; Lian, Bijun ; Xu, Chuanliang ; Dong, Baijun ; Huang, Huaqiang ; Wang, Yan ; Shi, Haoqing ; Gao, Xu ; Li, Jing ; Zhang, Wenhui

Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer, with a 10% five-year survival rate. However, little is known about its origin and the mechanisms governing its emergence. Our study characterized ADPC and NEPC in prostate tumors from 7 patients using scRNA-seq. First, we identified two NEPC gene expression signatures representing different phases of trans-differentiation. New marker genes we identified may be used for clinical diagnosis. Second, integrative analyses combining expression and subclonal architecture revealed different paths by which NEPC diverges from the original ADPC, either directly from treatment-naïve tumor cells or from specific intermediate states of treatment-resistance. Third, we inferred a hierarchical transcription factor (TF) network underlying the progression, which involves constitutive regulation by ASCL1, FOXA2, and selective regulation by NKX2-2, POU3F2, and SOX2. Together, these results defined the complex expression profiles and advanced our understanding of the genetic and transcriptomic mechanisms leading to NEPC differentiation.

01 Dec 2021·Nature Reviews NephrologyQ1 · MEDICINE

The Mesangial cell — the glomerular stromal cell

Q1 · MEDICINE

Review

Author: Shaw, Andrey S ; Chung, Jun-Jae ; Oxburgh, Leif ; Korin, Ben ; Avraham, Shimrit

Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and the glomerular response to injury. A growing body of evidence demonstrates that mesenchymal stromal cells, such as stromal fibroblasts, pericytes and vascular smooth muscle cells, not only specify the architecture of tissues but also regulate developmental processes, vascularization and cell fate specification. In addition, through crosstalk with neighbouring cells and indirectly through the remodelling of the matrix, stromal cells can regulate a variety of processes such as immunity, inflammation, regeneration and in the context of maladaptive responses - fibrosis. Insights into the molecular phenotype of kidney mesangial cells suggest that they are a specialized stromal cell of the glomerulus. Here, we review our current understanding of mesenchymal stromal cells and discuss how it informs the function of mesangial cells and their role in disease. These new insights could lead to a better understanding of kidney disease pathogenesis and the development of new therapies for chronic kidney disease.

100 Deals associated with PIN Pharma Inc.

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100 Translational Medicine associated with PIN Pharma Inc.

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Pipeline

Pipeline Snapshot as of 20 Jul 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

1

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