Exploratory Study to Evaluate the Safety and Preliminary Efficacy of Anti-CDH17 CAR-T Cell Injection in Patients With CDH17-positive Advanced Malignant Solid Tumors

This is a single-arm, open-label, exploratory clinical study to evaluate the safety and preliminary efficacy of Anti-CDH17 CAR-T cell injection in patients with CDH17-positive advanced malignant solid tumors.

Start Date08 Jul 2024

Sponsor / Collaborator

Shanghai Pudong Hospital

[+1]

NCT06487377

/ RecruitingPhase 1IIT

A Clinical Study of IX001 TCR-T In the Treatment of Advanced Pancreatic Cancer and Colorectal Cancer Induced by KRAS Mutations

This is a single-arm, single-center, open-label clinical study aimed at evaluating the safety and efficacy of IX001 TCR-T (T cell receptor-engineered T-Cell) injection in patients with advanced pancreatic cancer and colorectal cancer induced by KRAS (Kirsten Rat Sarcoma Viral Oncogene) mutations. A total of 6-18 evaluable patients are planned to be enrolled. The study will include 4 dose groups, using a '3+3' dose escalation design.

Start Date01 Jul 2024

Sponsor / Collaborator

Shanghai Pudong Hospital

[+1]

NCT06541444

/ RecruitingEarly Phase 1

An Open, Single Center Exploratory Study to Evaluate Safety and Efficacy of NK520 for Patients With Relapsed/Refractory Acute Myeloid Leukemia

This study will evaluate the safety and efficacy of NK520 in the treatment of relapsed/refractory acute myeloid leukemia. NK520 will be administered by intravenous injection. The safety and efficacy of this treatment will be evaluated.

Start Date01 Jul 2024

Sponsor / Collaborator

Base Therapeutics (Shanghai) Ltd.

[+1]

100 Clinical Results associated with Shanghai Pudong Hospital

0 Patents (Medical) associated with Shanghai Pudong Hospital

879

Literatures (Medical) associated with Shanghai Pudong Hospital

01 Apr 2025·Talanta

An Auger electron-loaded theranostic biosensor triggered by the ACE2-mediated virus/host endocytosis

Article

Author: Wang, Ruizhi ; Lou, Jingjing ; Chen, Hui ; Li, Danni ; Jin, Liang ; Li, Rou ; Li, Jie ; Xue, Shuai ; Zhou, Pan ; Zuo, Changjing ; Guo, Zhongqiu ; Li, Xiao ; Xu, Wen

Accurate diagnosis and effective antiviral strategies are critical to combat acute infection and to avoid damage to the host. Due to their restricted radiation range and energy, Auger electron emitters have shown potential as a RNA-destructing radionuclide therapy in oncology and infection. Focusing on the process of angiotensin-converting enzyme 2 (ACE2)-mediated endocytosis, Technetium-99m-labeled DX600 (^99mTc-DX600) was synthesized as an Auger electron vector to specifically bind to surface-expressed ACE2 proteins on 293T-hACE2 cells (293T cells stably expressing human ACE2), and Technetium-99m-loaded microvesicles (^99mTc-MVs) served as an antiviral tracer and effector in pseudovirus infection. The whole-body ACE2 expression evaluation was non-invasive, meanwhile, the enhanced green fluorescent protein expression of pseudoviruses was substantially inhibited as a result of the ^99mTc-DX600 loading of microvesicles, though the mitochondrial and DNA stabilities of the host cells were not affected. Furthermore, the in vivo distribution of ^99mTc-DX600 in humanized ACE2 mice was demonstrated to be both ACE2-specific and long-lasting, and an antiviral effect was fully exhibited with two cycles of intravenous injection at a dosage of 37 MBq. Taking advantage of the ACE2-mediated interaction and natural trigger mechanism of virus-induced endocytosis, ^99mTc-MV represents a theranostic biosensor of Auger electrons that can expose viral RNA to lethal amounts of radiation, with the host cells receiving no detrimental radiation.

01 Feb 2025·Journal of Advanced Research

Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model

Article

Author: Zengyu, Zhang ; Zhilan, Tu ; Yan, Xi ; Chao, Li ; Pengpeng, Jin ; Hualan, Yang ; Weiwei, Li ; Zimin, Guo ; Shuangxing, Hou

INTRODUCTIONSalidroside (SAL), extracted from Rhodiola rosea, has been widely used in coronary heart disease and myocardial ischemia for decades. Previous studies have demonstrated that SAL could reduce arteriosclerosis, and thus combat ischemic brain damage. However, the in-depth function of the salidroside in Cerebral Small Vascular Disease (CSVD) has not been discovered, and related molecular mechanism is still unclear.OBJECTIVESThe present study aims to explore the effects of salidroside in angiogenesis as well as repair of blood brain barrier (BBB) and its possible mechanisms.METHODSWe established a rat model of SHR via 2-vessel gradual occlusion (SHR-2VGO) to mimic the CSVD. Subsequently, the MRI, pathomorphism, as well as Morriss water maze test were conducted to determine CSVD-related indicators. 8 weeks post-surgery, animals were randomly administered SAL, DAPT, ATN161 or saline.The aim was to explore the protective effects of SAL in CSVD as well as its possible mechanism.RESULTSHere we found that SAL could attenuate cerebral hypoperfusion-induced BBB disruption, promote the pro-angiogenesis through enhancing the cell budding. Further investigations demonstrated that SAL could significantly increase the expression of Notch1, Hes1, Hes5, and ITGB1. In addition, we confirmed that SAL could activate Notch signal path, and then up-regulate ITGB1 to promote pro-angiogenesis and thus protect BBB from disruption.CONCLUSIONThe aforementioned findings demonstrated that SAL could protect BBB integrity through Notch-ITGB1 signaling path in CSVD, which indicated that SAL could be a potential medicine candidate for CSVD treatment.

01 Jan 2025·Annals of Vascular Surgery

Retrospective Analysis of a Novel Grading System for Evaluating the Long-Term Benefit of Revascularization on Carotid Artery Stenosis

Article

Author: Tang, Jingdong ; Liang, Kun ; Deng, Ying ; Tan, Jinyun ; Wang, Jie ; Tong, Jindong ; Fan, Weijian ; Yu, Bo ; Shi, Weihao

BACKGROUNDTo estimate revascularization benefit for carotid artery stenosis, with a novel grading system containing symptoms, stenosis, plaque, and collateral compensation (SSPC grading system).METHODSA retrospective multicenter study examined 945 consecutive patients diagnosed with carotid stenosis from January 2013 to December 2017. The cohort was classified into 2 groups: the revascularization group and the best medical therapy (BMT) group. Demographic, clinical, and lesion characteristics of all patients were recorded and 5-year nonprocedural stroke survival was calculated using Kaplan-Meier curve analyses.RESULTSOf the 945 patients, 514 underwent carotid revascularization (483 for carotid endarterectomy and 31 for transfemoral-carotid artery stenting) and 431 patients were treated with BMT. Patients in the revascularization group had a significantly higher proportion of preprocedural stroke/transient ischemic attack (TIA) and grades of stenosis. Of the patients in the revascularization group, 3.1% were classified as SSPC I, 10.3% as SSPC II, 41.4% as SSPC III, and 45.1% as SSPC IV. Meanwhile, 17.9% were classified as SSPC I, 19.7% as SSPC II, 49.2% as class III, and 13.2% had class IV in the BMT group. Procedural stroke developed in 13 patients (2.5%) following revascularization (10 of them were non-disabling). The overall rate of freedom from any nonprocedural stroke was 94.1 ± 1.1% in the revascularization group and 89.5 ± 1.6% in the BMT group (P = 0.01). Subgroup analysis was conducted for asymptomatic carotid stenosis (ACS) and carotid near-occlusion (CNO) patients. Nonsignificance was noted in the rate of freedom from any nonprocedural stroke between revascularization and BMT in both ACS and CNO subgroups (P = 0.09 and 0.12, respectively). Of note, in ACS patients graded as SSPC III, a significant difference in stroke survival was found between the revascularization and BMT group (96.0 ± 2.0% vs. 89.1 ± 2.4%, P = 0.04). Meanwhile, in symptomatic CNO patients, similar results were found regarding SSPC classification (94.8 ± 3.6% vs. 63.8 ± 14.9%, P = 0.01).CONCLUSIONSThe SSPC grading system stratifies the patients with carotid artery stenosis and predicts the long-term benefits of revascularization. Meanwhile, potential revascularization benefits could be better attained via SSPC classes in specific patients with ACS and CNO.

100 Deals associated with Shanghai Pudong Hospital

100 Translational Medicine associated with Shanghai Pudong Hospital

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Pipeline Snapshot as of 02 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

IX001 TCR-T cells ( KRAS )	Pancreatic Cancer More	Phase 1
Chimeric exosomal tumor vaccines(Shanghai Pudong Hospital)	Bladder Cancer More	Pending
Autologous Rak Cells(Shanghai Pudong Hospital)	Glioma More	Pending

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