Zhejiang Yatai Pharmaceutical Co., Ltd.

Main study objectives This study investigates the pharmacokinetics of the test preparation atenolol tablets (specification: 50 mg/tablet, manufacturer: Zhejiang Asia Pacific Pharmaceutical Co., Ltd.) and the reference preparation atenolol tablets (trade name: Tenormin®, specification: 50 mg/tablet, manufacturer: Norwich Pharmaceuticals, Inc.) in healthy adult subjects after a single oral administration under fasting and fed conditions, and evaluates the bioequivalence of the two preparations after fasting and fed oral administration. Secondary study objectives Observe the safety of a single oral administration of 50 mg of the test preparation atenolol tablets or the reference preparation atenolol tablets (trade name: Tenormin®, 50 mg) in healthy subjects.

The pharmacokinetics of the test preparation diltiazem hydrochloride tablets (specification: 30 mg, produced and provided by Zhejiang Asia Pacific Pharmaceutical Co., Ltd.) and the reference preparation diltiazem hydrochloride tablets (trade name: Hexinshuang®, specification: 30 mg, certified by Tianjin Tanabe Pharmaceutical Co., Ltd. and provided by Zhejiang Asia Pacific Pharmaceutical Co., Ltd.) taken orally in healthy adult subjects in the fasting and fed state were studied, and the bioequivalence of the two preparations taken orally in the fasting and fed state was evaluated.

Terazosin hydrochloride tablets produced by Zhejiang Asia Pacific Pharmaceutical Co., Ltd. were used as the test preparation (T), and Terazosin hydrochloride tablets (Golteline®) produced by Shanghai Abbott Pharmaceuticals Co., Ltd. were used as the reference preparation (R). The bioavailability of the test preparation and the reference preparation after a single oral administration in healthy subjects under fasting conditions was evaluated, and the bioequivalence of the two preparations was evaluated. Secondary objective: To investigate the safety of the test preparation and the reference preparation after oral administration in healthy subjects.