Delving into the Latest Updates on Korea Food Research Institute with Synapse

Overview

Tags

Nervous System Diseases

Endocrinology and Metabolic Disease

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

No Data

Disease Domain	Count

Endocrinology and Metabolic Disease	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

Edible insects, known for their high-protein production efficiency, are vital for enhancing food security.However, standardized breeding protocols are lacking, and research on the impact of cage materials on insect product composition is limited.This study investigated the volatile compounds and processing properties of protein from Protaetia brevitarsis larvae reared in plastic and glass cages.Protein extracts from larvae reared in plastic cages contained 14 types of hydrocarbons, 4 types of ketones, and 1 type of phenol.Those reared in glass cages contained two types of acids, seven types of alcs., and five types of aldehydes.Notably, plastic-derived compounds, such as p-xylene (110.87 μg/mL) and o-xylene (37.98 μg/mL), were significantly higher in the extracts from plastic cages, indicating potential plastic exposure.Processing properties, including protein solubility, pH, color, foaming properties, and emulsion characteristics, showed no significant differences between the two rearing conditions (P > 0.05).Therefore, considering the detection and potential accumulation of plastic-derived volatile compounds, using glass cages may be more beneficial for rearing insects for protein production

01 Nov 2024·Biochemical and Biophysical Research Communications

Influence of different types of dietary sugars on the intestinal mucosa and hepatic lipid metabolism in germ-free mice

Article

Author: Jhun, Hyunjhung ; Lee, Yu Ra ; Son, Hee-Kyoung ; Park, Miri ; Lee, Hye-Bin ; Park, Ho-Young

The excessive consumption of dietary sugar induces changes in gut microbiota, which is associated with obesity and metabolic dysregulation. This study investigated the effects of monosaccharide and fructooligosaccharide (FOS) intake on metabolic function and intestinal environment in germ-free (GF) mice lacking gut microbiota. GF mice were provided with a chow diet and administered a water solution containing 15 % glucose, fructose, or FOS for 4 weeks. Compared with FOS, glucose, and fructose induced increased hepatic lipid accumulation, increased adipocyte size in white adipose tissue, and upregulated hepatic lipogenic gene expression. FOS exhibited notably higher activation of hepatic AMP-activated protein kinase compared with those consuming glucose or fructose. Moreover, the number of goblet cells in the intestinal mucosa increased significantly with FOS consumption. Collectively, these findings indicate that while monosaccharides caused metabolic disorders in GF mice, FOS alleviated these disorders and increased the number of goblet cells in the intestinal mucosa. These results provide evidence for the occurrence of these effects independently of the gut microbiota.

01 Nov 2024·Analytical Letters

Seasonal and Root-Specific Metabolomic Profiles of Panax Ginseng Meyer by Ultra-High Performance Liquid Chromatography-Quadrupole-Time-of-Flight-Mass Spectrometry (UPLC-QTOF-MS) and Partial Least Squares-Discriminant Analysis (PLS-DA)

Author: Park, Jong-Jin ; Ahn, Jae-Hwan ; Choi, Jae Woong ; Rhee, Young Kyoung ; Cho, Chang-Won ; Song, Nho-Eul ; Lim, Jeong-Ho ; Oh, Mira ; Hong, Hee-Do ; Han, Ah-Ram

The chem. composition of ginseng varies by several factors such as age, harvest season, and region.Each part of fresh ginseng contains certain valuable bioactive compounds; however, chem. studies of ginseng have focused on the ginsenoside content.In this study, we examine the chem. composition of Panax ginseng Meyer as related to harvest season and specific root parts via untargeted metabolomics using ultra-high performance liquid chromatog.-quadrupole-time-of-flight-mass spectrometry (UPLC-QTOF-MS).Multivariate statistical anal. such as partial least squares discriminant anal. (PLS-DA) was used to select significant metabolites distinguishing ginseng harvested in different seasons and various ginseng parts.The selected thirteen metabolites were identified as amino acids, ginsenosides, and fatty acid amides through MS fragment pattern anal.Addnl. chemometric anal. revealed chem. consistency between main and fine roots regardless of harvest time, indicating a stable chem. composition in P. ginseng among seasons.Furthermore, most ginsenosides among the thirteen selected metabolites had higher abundance in fine roots than in main roots, while primary metabolites were more abundant in main roots, highlighting a unique chem. composition dependent on the specific root parts.

100 Deals associated with Korea Food Research Institute

Login to view more data

100 Translational Medicine associated with Korea Food Research Institute

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 29 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

Login to view more data