Clinical Efficacy of Surgical Vs. Conservative Treatment for Atlantoaxial Dislocation Patients Without Neurological Deficit: a Prospective, Multicenter, Observational Study

The goal of this observational study was to learn about the long-term clinical efficacy of conservative treatment in atlantoaxial dislocation patients without neurological deficit. The main question it aims to answer is:
Is surgical intervention always necessary in atlantoaxial dislocation patients without nerve deficit?
Patients who refuse surgical intervention will continue to be treated conservatively. Clinical outcomes will be summarized over five years of follow-up

Start Date15 Jan 2025

Sponsor / Collaborator

Peking University Third Hospital

[+8]

ChiCTR2400094898

/ SuspendedNot ApplicableIIT

Research on Screening Early Tumor Markers of Cholangiocarcinoma by Utilizing Multi-omics Technology

Start Date05 Jan 2025

Sponsor / Collaborator

The Third Hospital of Hebei Medical University

100 Clinical Results associated with The Third Hospital of Hebei Medical University

0 Patents (Medical) associated with The Third Hospital of Hebei Medical University

514

Literatures (Medical) associated with The Third Hospital of Hebei Medical University

01 Mar 2025·Neuropharmacology

Short chain fatty acids mediates complement C1q pathway alleviation of perioperative neurocognitive disorders

Article

Author: Wang, Qiujun ; Yu, Yaozong ; Zhao, Bo ; Tan, Xiaona ; Niu, Junfang ; Liu, Xiang

Perioperative neurocognitive disorders (PND) is one of the most common postoperative complications, which can lead to a harmful impact on self-dependence, longer hospital stays, increased medical costs, morbidity, and mortality amongst older adults. Microglia can modulate synapse elimination involved in the complement component protein 1q (C1q) pathway to induce cognitive dysfunction, which is significantly improved by short chain fatty acids (SCFAs) treatment. Here we investigate the effects of SCFAs treatment on PND via mediating C1q complement pathway. High-throughput sequencing of 16S rDNA from fecal samples of male SD rats was applied to assess the changes in gut microbiota. Fecal microbiota transplantation (FMT) was performed to investigate whether gut microbiota from PND rats could alter cognitive impairment. The blood from the rat tail vein was collected to measure the SCFAs concentrations. Hippocampal and brain tissue samples were obtained to perform Western blots, Golgi and immunofluorescence staining. Primary microglia treated with SCFAs or Histone deacetylase inhibitor were cultured to measure microglial activation states and the expression of acetylated histone. The 16S rDNA sequencing results showed that PND rats had the significant changes in the species diversity of the gut microbiota and the metabolite of specifc species. Gut microbiota from PND rats could alter spatial learning and memory, and meanwhile, the changed SCFAs concentrations in plasma were involved. The synapse elimination in PND rats was strikingly reversed by SCFAs treatment involved in modulation complement C1q via suppressing neuroinflammation. This suggests that a link between gut microbiota dysbiosis and cognitive function impairment is involved in synapse elimination via mediating complement C1q pathway. SCFAs treatment can alleviate PND, the mechanisms of which may be associated with regulating complement C1q pathway.

01 Feb 2025·European Journal of Radiology

Diagnostic performance of dual-energy computed tomography (DECT) quantitative parameters for detecting metastatic cervical lymph nodes in patients with papillary thyroid cancer: A systematic review and meta-analysis

Article

Author: Li, Yize ; Chen, Ziqi ; Dai, Xinpeng ; Gao, Huimin ; Zhang, Luyao ; Chen, Yingmin

PURPOSEThis study systematically evaluated the diagnostic performance of dual-energy computed tomography (DECT) quantitative parameters in detecting cervical lymph node metastasis in patients with papillary thyroid cancer (PTC).METHODWe searched PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Data databases for relevant original studies from database inception to March 2024. The quality of the included studies was evaluated using the QUADAS-2 tool. A bivariate random-effects model was used to calculate the pooled sensitivity and specificity of DECT. The threshold effect was determined by calculating Spearman correlation coefficients, meta-regression and subgroup analysis were performed to evaluate the sources of variability. Publication bias was assessed using the asymmetry of Deek's funnel plot.RESULTSThirteen studies involving 951 patients (2,782 lymph nodes) were included in this meta-analysis. We analyzed four quantitative parameters of DECT, among which the normalized iodine concentration (NIC) in the arterial phase had the highest area under the receiver operating characteristic curve (AUC). The combined sensitivity, specificity, and AUC were 83 % (95 % confidence interval [CI]: 76 % - 89 %), 90 % (95 % CI: 82 % - 95 %), and 0.92 (95 % CI: 0.90 - 0.94), respectively. The Spearman correlation coefficient was - 0.244 (p = 0.4). Meta-regression and subgroup analysis revealed that use of blinding, mean patients' age, female proportion, presence of Hashimoto's thyroiditis, number of lymph nodes included in the study, and slice thickness were sources of heterogeneity for the NIC in the arterial phase. No significant publication bias was observed among the studies.CONCLUSIONSDECT, a noninvasive technique, can be used to distinguish metastatic from nonmetastatic cervical lymph nodes in patients with PTC by measuring quantitative lymph node parameters.

01 Feb 2025·Pharmacology Biochemistry and Behavior

Juvenile chronic social defeat stress reduces prosocial behavior in adult male mice

Article

Author: An, Xiangyu ; Zhang, Mingxu ; Shi, Haishui ; Zhao, Zihan ; Qian, Ningyuan ; Cui, Yajie ; Shao, Juan ; Zhao, Mingyang ; Qie, Xiaojuan ; Tang, Qiqi ; Lu, Minghao ; Song, Li

Exposure to stress in early life can have a significant impact on individuals. However, the effects of early-life stress (ELS) on prosocial behavior remain unclear, as do the underlying mechanisms. In this study, ICR juvenile mice were subjected to juvenile chronic social defeat stress (jCSDS) between postnatal days 32 and 41, during which body weight changes were continuously monitored. The behaviors of adult mice were evaluated using the open field test (OFT), the social interaction test (SIT), and the prosocial choice task (PCT). ELISA was used to quantify serum levels of oxytocin, serotonin, and dopamine. The density of dendritic spines in the basolateral amygdala was evaluated by Golgi staining. Behavioral test results showed that jCSDS induced anxiety-like behavior and decreased prosocial selection tendency in mice. Additionally, exposure to jCSDS increased the serum levels of oxytocin, decreased those of serotonin, and increased the density of dendritic spines in the basolateral amygdala. Correlation analysis indicated that prosocial behavior was negatively correlated with serum oxytocin levels and dendritic spine density in the basolateral amygdala. These results suggested that jCSDS reduced prosocial behavior, possibly due to changes in serum oxytocin contents and adaptive changes in amygdaloid neurons.

100 Deals associated with The Third Hospital of Hebei Medical University

100 Translational Medicine associated with The Third Hospital of Hebei Medical University

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 07 Feb 2025

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

The Third Hospital of Hebei Medical University

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 07 Feb 2025

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing