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Neoplasms

Small molecule drug

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A glimpse into the focused therapeutic areas

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Disease Domain	Count

Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

PRMT1(Protein arginine N-methyltransferase 1)	1

Although traditional type II heterojunction designs for artificial photosynthesis show promise for photocatalytic hydrogen production, their redox capacity is somewhat limited due to the spatial separation of hydrogen evolution and oxidation reactions at less favorable sites. To overcome this limitation, ohmic junctions based on type II heterojunctions have been designed to enhance hydrogen evolution by transferring electrons to the metal component. In this study, a copper powder graphdiyne (Cu-GDY) composite catalyst with ohmic angle contact was synthesized by coupling copper foil with hexa-hexylbenzene. Incorporating Cu-GDY into CoGdO₃ results in an interleaved band structure forming a type II heterojunction at the contact interface. This configuration overcomes the issue of the unfavorable conduction band position of CoGdO₃, thereby promoting charge transfer. The internal electric field created by the Fermi level difference between Cu-GDY and CoGdO₃, increase in REDOX capacity is the main reason for the increase of carrier separation rate. In addition, the plasmonic properties of copper expand the active reaction sites and promote the hydrogen evolution reaction. The composite catalyst exhibits b a hydrogen production rate that is 10.5 times higher than that of the individual catalysts. This work demonstrates that the formation of two distinct contact interfaces between Cu-GDY and CoGdO₃ significantly improves the electron transfer and hydrogen evolution performance.

01 Jan 2025·Biofabrication

3D printed PGCL@PLA/10CSPL composite scaffolds loaded with fibronectin 1 for intervertebral disc degeneration treatment

Article

Author: Dai, Zhiwen ; Liang, Jinguo ; Wang, Zhongwei ; Rong, Hongrui ; Chen, Siyuan ; Li, Zhencong ; Zhang, Weilin ; Wei, Yen ; Guo, Weixiong ; Wei, Jinsong ; Ouyang, Qianqian ; Huang, Shengbang

AbstractRestoration of disc height and biomechanical function is essential for intervertebral disc degeneration (IDD) treatment. Removing abnormal nucleus pulposus (NP) tissue is an important step to facilitate bony fusion during the healing process. We analyzed publicly available single-cell transcriptome data for human normal and degenerative NP to identify genes associated with NP degeneration. A novel poly(glycolide-co-caprolactone)@polylactide (PLA)-b-aniline pentamer (AP)-b-PLA/chitosan-ϵ-polylysine (PGCL@1PAP/10CSPL) scaffold with good biocompatibility and electroactivity was designed and fabricated as an implant for IDD treatment using 3D printing technology. The PGCL@1PAP/10CSPL scaffold exhibited superior hydrophilicity, mechanical properties, cytocompatibility, and antibacterial activity compared to PGCL. Fibronectin 1 (FN1), identified from single-cell transcriptome analysis, was loaded into the PGCL@1PAP/10CSPL scaffold to accelerate the abnormal NP degeneration. In vitro and in vivo experiments indicated that the PGCL@1PAP/10CSPL-FN1 scaffold enhanced osteogenic differentiation, promoted angiogenesis, and facilitated the removal of damaged disc tissue. This study introduces a novel implant system with desirable mechanical strength and unique bone-promoting and vascularizing properties for lumbar interbody fusion in IDD treatment.

01 Jan 2025·Journal of Alloys and Compounds

Influence of electric pulse on microstructural characteristics and mechanical properties of cast AZ91D magnesium alloy

Author: Zhou, Yuezhang ; Zhang, Yong ; Liu, Xinyu ; Liu, Dehua ; Geng, Guihong

The application of high-energy elec. pulses has emerged as a promising technique for refining the grain structure, inducing solid phase transformations, and weakening the weave structure of cast AZ91D magnesium alloy, thereby enhancing its rolling performance during molding processes.This study investigates the comparative effects of elec. pulse treatment, homogenized annealing, and their combination on the microstructure and mech. properties of cast AZ91D magnesium alloy under various process conditions.Elec. pulse treatment offers several advantages over traditional homogenized annealing methods, including high energy efficiency, reduced processing time, and eco-friendly energy conservation.By avoiding excessive heating and material deformation, this method ensures improved integrity and stability of the material.This study provides an in-depth anal. of how changes in frequency and voltage during elec. pulse processing influence the microstructure and mech. properties of the alloy.Exptl. results reveal that optimal enhancements occur at a pulse frequency of 640 Hz and an output voltage of 240 V, which refine the β-Mg₁₇Al₁₂ phase from a large flaky structure to a fine worm-like form, resulting in significant grain refinement and reduced weaving strength.Consequently, there is a substantial improvement in mech. properties, with the specimens transitioning from brittle fracture to a mixed brittle-tough fracture mode.Tensile strength and elongation exhibit remarkable enhancements of 51.4% and 91.7%, resp., compared to untreated specimens.Furthermore, the combined application of elec. pulse treatment across all three processing conditions consistently yields superior results, while homogenized annealing followed by elec. pulse treatment leads to a decline in mech. properties.These findings highlight the efficacy of elec. pulse treatment as a viable method for enhancing the microstructure and mech. properties of cast AZ91D magnesium alloy, with significant implications for optimizing manufacturing processes in various industries.

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Pipeline

Pipeline Snapshot as of 14 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

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