Guangzhou Boji New Drug Clinical Research Centre

To observe the safety, tolerability, and permeation dynamics of a single dose of different concentrations of pazufloxacin mesylate ear drops in patients with acute suppurative otitis media or acute exacerbation of chronic suppurative otitis media

(1) Using placebo as control, preliminarily evaluate the efficacy and safety of Nitrogen and Dan Granules in the treatment of chronic cholecystitis (liver and gallbladder damp-heat syndrome). (2) Explore the optimal effective dose of Nitrogen and Dan Granules in the treatment of chronic cholecystitis (liver and gallbladder damp-heat syndrome) to provide a basis for Phase III clinical trials.

To observe the safety and tolerability of a single dose of different concentrations of pazufloxacin mesylate ear drops in patients with active simple chronic suppurative otitis media, and to evaluate the local and systemic pharmacokinetics of pazufloxacin mesylate ear drops.