A prospective study on the learning curve in the analysis of FFR angiography - A prospective study on the learning curve in the analysis of FFR angiography

Start Date01 Sep 2023

Sponsor / Collaborator

Mie University Hospital

JPRN-UMIN000045468 / CompletedIIT

A multicenter study of patient questionnaires regarding the omission of breast surgery - A multicenter study of patient questionnaires regarding the omission of breast surgery

Start Date13 Sep 2021

Sponsor / Collaborator

Mie University Hospital

JPRN-UMIN000045200 / RecruitingIIT

The clinical survey of self-management of patients with chronic heart failure using the heart failure management application. - The clinical survey of self-management of patients with chronic heart failure using the heart failure management application.

Start Date18 Aug 2021

Sponsor / Collaborator

Mie University Hospital

100 Clinical Results associated with Mie University Hospital

0 Patents (Medical) associated with Mie University Hospital

1,142

Literatures (Medical) associated with Mie University Hospital

31 Dec 2024·Hematology

Venetoclax is effective for chronic myelomonocytic leukemia blastic transformation with RUNX1 mutation

Article

Author: Oka, Koji ; Kageyama, Shinichi ; Sugimoto, Yuka ; Ohya, Eiko ; Watanabe, Yasuyuki ; Nagaharu, Keiki ; Kashima, Emiko ; Tawara, Isao ; Ikejiri, Makoto

Background: Chronic myelomonocytic leukemia is a clonal hematological disorder with an inherent risk of transformation to acute myeloid leukemia. Recently, there has been exponential discovery of molecular abnormalities in patients with chronic myelomonocytic leukemia. Some of these mutations independently contribute to a higher risk of transformation and result in inferior overall survival. Treatment strategies for patients undergoing blastic transformation in chronic myelomonocytic leukemia, especially after progressing on hypomethylating agents, are currently limited.Case presentation: We present a case of a 70-year-old male patient with chronic myelomonocytic leukemia blastic transformation with RUNX1 mutation following azacitidine monotherapy. Notably, he achieved hematological complete remission after the first course of venetoclax plus azacitidine, leading to the disappearance of RUNX1 mutation. We performed serial assessments of molecular analysis by next generation sequencing throughout his clinical course.Conclusion: The presence of RUNX1 mutation is associated with higher response rates to venetoclax-based combination therapies in chronic myelomonocytic leukemia with blastic transformation. Our findings suggest that even after azacitidine monotherapy, venetoclax plus azacitidine is effective in targeting leukemic clones harboring RUNX1 mutations. Furthermore, we emphasize the significance of molecular analysis, including next-generation sequencing, in providing insights into the detailed dynamics of clonal evolution and guiding treatment decisions.

01 Dec 2024·IJC Heart & Vasculature

Test-retest reproducibility of absolute myocardial blood flow obtained using stress dynamic CT myocardial perfusion imaging

Article

Author: Kitagawa, Kakuya ; Takafuji, Masafumi ; Hasegawa, Daisuke ; Sakuma, Hajime ; Nakamura, Satoshi

BackgroundCoronary artery disease (CAD) and coronary microvascular disease (CMD) are significant contributors to angina pectoris, necessitating reliable diagnostic techniques for effective management. While positron emission tomography has been the non-invasive gold standard for myocardial blood flow (MBF) quantification, stress dynamic CT myocardial perfusion imaging (CTMPI) has emerged as a promising alternative. This study aimed to evaluate the test-retest reproducibility of MBF measurements obtained using dynamic CTMPI.MethodsThe study retrospectively analyzed MBF values from two dynamic CTMPI examinations conducted in the same patient cohort (n = 30) to examine the consistency of MBF quantification and the ability to visually detect and grade abnormal perfusion suggesting ischemia between the tests. Global and remote MBF were defined as the mean MBF and the maximum MBF of all segments, respectively.ResultsMBF quantification revealed strong linear correlations between the tests (r = 0.89 for global MBF, r = 0.88 for remote MBF, and r = 0.82 for all segments), and intraclass correlation coefficients reflected high agreement between the tests (0.94 for global MBF, 0.93 for remote MBF, and 0.90 for all segments). Bland-Altman plots indicated a negligible mean difference with acceptable limits of agreements between the tests for global MBF, remote MBF, and all segments. Visual assessment of the CTMPI maps for abnormal perfusion suggesting ischemia yielded a good inter-test agreement with a weighted kappa value of 0.80.ConclusionDynamic CTMPI can consistently reproduce absolute MBF values and reliably detect myocardial perfusion abnormalities, potentially making it a robust diagnostic tool for evaluating the presence and severity of CAD and CMD.

01 Nov 2024·Journal of Infection and Chemotherapy

Epidemiological study of respiratory syncytial virus infection in adults during the pandemic of COVID-19

Article

Author: Hirai, Jun ; Takayama, Mina ; Mikamo, Hiroshige ; Yamada, Atsuko ; Suematsu, Hiroyuki ; Asai, Nobuhiro ; Ohta, Toshihiro ; Kato, Hideo ; Sakanashi, Daisuke ; Miyazaki, Narimi ; Mori, Nobuaki ; Shibata, Yuichi ; Hagihara, Mao ; Ohashi, Wataru ; Nakamura, Akiko ; Kawamoto, Yuzuka ; Chida, Sumie ; Ohno, Tomoko ; Koita, Isao

INTRODUCTIONWhile respiratory syncytial virus (RSV) is one of the most common pathogens in adults admitted to the ICU due to respiratory diseases, no reports regarding the occurrence rate of RSV infections in adults in Japan during the COVID-19 pandemic exist.PATIENTS AND METHODSWe conducted this retrospective study to examine the exact occurrence rate of RSV infections in adults. We reviewed all patients (≥18 years) with any respiratory symptoms who received quantitative polymerase chain reaction (PCR) using nasopharyngeal samples for respiratory viruses by GeneLEAD at the Aichi Medical University Hospital between November 2022 and November 2023.RESULTSA total of 541 adult patients who underwent PCR test were enrolled in this study. RSV was identified in 18 cases (3.3 %); 8 (1.5 %) upper and 10 (1.8 %) lower respiratory tract infections. Influenza A and SARS-CoV-2 were found in 10 (1.8 %) and 61 (11.3 %), respectively. Patients with RSV infections and COVID-19 had more comorbidities than those with Influenza virus infections. As for RSV-associated with lower respiratory tract infection cases, 10 developed acute respiratory failure, resulting in 1 fatal case due to pneumonia and 1 died of septic shock due to ileus. The 30-, 90-day mortality rates were 1 (6 %) and 2 (11 %) respectively.CONCLUSIONAbout 3 % of adults had RSV infections during the COVID-19 pandemic. The outcomes of RSV infections in adults were similar to those by COVID-19. Those with comorbidities should have a preventive method against RSV infections, the same as for COVID-19.

100 Deals associated with Mie University Hospital

100 Translational Medicine associated with Mie University Hospital

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