Title:
Single-Session Radiofrequency Ablation for the Treatment of Benign Thyroid Nodules: A Prospective Study
Purpose:
The goal of this clinical trial is to learn if single-session radiofrequency ablation (RFA) can effectively reduce the volume of benign thyroid nodules in adults. It will also evaluate the safety of the RFA procedure.
The main questions it aims to answer are:
1. Does single-session RFA reduce the size of thyroid nodules (measured by volume reduction rate - VRR)?
2. What medical problems or complications do participants experience after undergoing RFA?
3. How does RFA affect thyroid hormone levels (TSH, FT4)?
4. Is RFA equally effective in purely cystic nodules, solid, and predominantly cystic nodules?
Comparator:
This is a single-arm study, so there is no placebo or comparison treatment group. All participants will undergo RFA, and the results will be assessed over time.
Participants will:
* Undergo one session of RFA for benign thyroid nodules.
* Be followed up with clinical visits and ultrasound assessments at 1, 6, and 12 months.
* Have thyroid hormone levels tested and nodule size measured by ultrasound at each follow-up.
* Be monitored for any side effects or complications such as voice changes, pain, or bleeding.

Start Date10 Feb 2023

Sponsor / Collaborator

Da Nang Hospital

NCT02923817

/ Unknown statusPhase 2IIT

Phase I-II Clinical Trial Using Bone Marrow-derived Mononuclear Cells for Spinal Cord Injury

The purpose of study is to determine whether autologous mononuclear cells deriving from the bone marrow are effective in the treatment of spinal cord injury.

Start Date01 Sep 2016

Sponsor / Collaborator

Da Nang Hospital

[+1]

100 Clinical Results associated with Da Nang Hospital

0 Patents (Medical) associated with Da Nang Hospital

Literatures (Medical) associated with Da Nang Hospital

08 Aug 2025·International Journal of Stroke

Clinical and Safety Outcomes Following Endovascular Treatment For Large Ischemic Core Stroke With Alberta Stroke Program Early Computed Tomography Score 3-5 in the 12-24-Hour Time Window.

Article

Author: Le, Tra Vu Son ; Duong, Hai Quang ; Tran, Vu Thanh ; Dang, Hung Minh ; Do, Huy Quoc ; Ha, Duc Tan ; Nguyen, Tran Tran Ngoc ; Tran, Hang Thi Minh ; Do, Binh Thi Thanh ; Nguyen, Thang Ba ; Pham, Thai Nguyen Thanh ; Chen, Yimin ; Doan, Hanh Thi My ; Bach, Dung Tri ; Nguyen, Trung Quoc ; Nguyen, Thanh N ; Dang, Huy Quang ; Phan, Bang ; Truong, Anh T L ; Le, Thien Quang ; Nguyen, Huy Thang ; Ngo, Trinh Thi Kim ; Nguyen, Trung Thanh ; Hoang, Dinh Chau Bao ; Huynh, Quoc Huy Quoc ; Nguyen, Nhi Thanh ; Pham, Binh Nguyen ; Nguyen, Lanh Chi ; Chiem, Duc Nguyen ; Nguyen, Huong Thi Bich ; Nguyen, Khang Vinh

INTRODUCTION:

Although efficacy and safety of endovascular treatment (EVT) for large-core ischemic stroke have been proven, most trials used perfusion imaging or included early-window patients, limiting generalizability to the late window, particularly in developing countries.

AIM:

We aimed to evaluate the safety and functional outcomes of EVT in large-core stroke patients treated between 12-24 hours (late window) from last known well (LKW).

METHODS:

We conducted a prospective, multicenter observational study across four comprehensive stroke centers in Vietnam, enrolling consecutive patients who underwent EVT within 24 hours of symptom onset between August 2023 and September 2024. Large core was defined by an Alberta Stroke Program Early CT Score (ASPECTS) of 3 to 5 on non-contrast computerized tomography (NCCT) or diffusion-weighted magnetic resonance imaging (DWI-MRI). Patients who underwent EVT within 12-24 hours after LKW were compared to those treated before 12 hours (early window). Primary and safety outcomes were independent ambulation (90-day mRS 0-3) and symptomatic intracranial hemorrhage (sICH). Secondary outcomes were 90-day mRS 0-2, ordinal mRS, successful reperfusion (modified Thrombolysis in Cerebral Infarction score ≥2b, early neurological deterioration (END)), and 90-day mortality.

RESULTS:

Of 1,872 patients receiving EVT, 343 with large ischemic cores (median age 64.0 years, 33.8% female) were included, with 103 (30.0%) treated in the 12-24-hour window. Compared to early-window patients, late-window patients had lower rates of intravenous thrombolysis (2.9% vs. 32.9%, p < 0.001), higher brain MRI use (51.5% vs. 16.2%, p < 0.001), and longer pre-treatment imaging-to-groin puncture times (106 vs. 77 minutes, p < 0.001). After adjusting for confounders, there were no significant differences in 90-day mRS 0-3 (56.3% vs. 55.0%, adjusted odds ratio [aOR] 0.71, 95% confidence interval [CI] 0.39-1.28, p = 0.26), ordinal mRS (aOR 1.21, 95% CI 0.78-1.90, p = 0.39), and sICH (aOR 1.12, 95% CI 0.32-3.50, p = 0.85). Other secondary outcomes were also similar.

CONCLUSIONS:

In patients with anterior circulation large vessel occlusion stroke and low ASPECTS, EVT at 12-24 hours versus <12 hours from symptom onset showed no significant differences in clinical or safety outcomes. Larger trials are needed to confirm these findings, especially in developing regions.

07 Aug 2025·BMC GASTROENTEROLOGY

Impact of timing of endoscopy on clinical outcomes in cirrhotic patients with esophageal variceal bleeding: a monocentric retrospective study from Vietnam.

Article

Author: Nguyen, Khoa Phuoc ; Nguyen, Xung Van ; Doan, Trung Hieu

INTRODUCTION:

In cirrhotic patients with esophageal variceal bleeding (EVB), most guidelines recommend endoscopy within 12 h. However, the optimal timing for the highest treatment efficacy remains controversial, and current studies provide inconsistent results. This study aims to evaluate the optimal timing by comparing clinical outcomes between early endoscopy (< 12 h) and delayed endoscopy (≥12 h) groups.

METHODS:

A retrospective study was conducted on 265 cirrhotic patients with EVB who underwent endoscopic variceal ligation (EVL) from January 2022 to December 2024. Patients were divided into early and delayed endoscopy groups based on the timing of endoscopic intervention since admission. The primary outcome was the 5-day treatment failure.

RESULTS:

Among the 265 eligible patients, 109 (41.1%) underwent early endoscopy, while 156 (58.9%) underwent delayed endoscopy. There were no statistically significant differences between the early and delayed endoscopy groups regarding 5-day treatment failure (10.1% vs. 9%, p = 0.759), in-hospital mortality (10.1% vs. 7.1%, p = 0.377), the need for ICU care (13.8% vs. 10.9%, p = 0.481), total blood transfusion units (p = 0.585), hemoglobin decrease requiring transfusion (p = 0.31), and the length of hospital stay (p = 0.35). Similarly, after Propensity Score Matching, no significant differences were observed between the two groups regarding those outcomes. Univariate and multivariate logistic regression analysis identified low systolic blood pressure (OR = 0.959, CI: 0.927-0.992), elevated serum creatinine levels (OR = 1.026, CI: 1.004-1.047), and Child-Pugh class C (OR = 7.516, CI: 1.538-36.721) at admission were independently associated with an increased risk of in-hospital mortality.

CONCLUSION:

The timing of endoscopy (before or after 12 h) does not significantly affect clinical outcomes in EVB patients. Endoscopy timing should depend on the patient's condition and clinical judgement. Key predictors of in-hospital mortality include low systolic blood pressure, high serum creatinine levels, and Child-Pugh class C at admission.

01 Jul 2025·ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Virtual Remote Pathology Education in Support of Virtual Remote Gynecologic-Oncology Training: The Open Pathology Education Network Pilot Proof of Concept Experience

Article

Author: Ng, Joseph S. ; Huynh, Lien ; Quy, Tran Tu ; Parkash, Vinita ; Tran, Ngoc TB ; Ngoc, Phan Thi Hong ; Quynh, Tran Thi Nhu ; Wong, Adele ; Hassell, Lewis A. ; Han, Truong Ngoc

Context.—:

The subspecialty workforce in pathology globally is inadequate for the demands of many modern therapies. The Open Pathology Education Network (OPEN) was formed to augment the global pathology workforce. The International Gynecologic Cancer Society (IGCS) virtual gynecologic-oncology (gyn-onc) fellowship training identified needs for higher-level pathology support.

Objective.—:

To report on an OPEN-IGCS pilot project to support gyn-onc and pathology education efforts in a developing country.

Design.—:

Curriculum with learning objectives and content from open sources was assembled. Mentoring sessions included bidirectional case sharing. Trainees received sequential curricula assignments and had options for communication outside mentoring sessions. Pretest and posttest digital slide assessments were included. Mentors attended the gynecology tumor board, allowing for the assessment of quality and accuracy of pathology diagnosis for cases discussed.

Results.—:

Learners completing the pretest and posttest showed substantial improvement, with 2 practicing pathologists improving their diagnostic scores from 60% to an average of 95%. A third trainee-level participant also improved, but to a lesser degree. Qualitative assessments included increased confidence in presentation and an increased ability to anticipate questions, raise issues of expanded differential diagnoses, and articulate appropriate workup. Observations of clinicians who participated also noted increased confidence in participating pathologists. Secondary value included establishing an expanded network of support in other subspecialties for participants. Pathologic issues at the tumor board decreased, from more than 50% in the first 3 months of study to 0% in the last 3 months of study. The curriculum was embedded into a self-paced learning portal at courses.open-pathology.org.

Conclusions.—:

The OPEN-IGCS collaboration model shows the potential to provide subspecialty pathology training remotely.

100 Deals associated with Da Nang Hospital

100 Translational Medicine associated with Da Nang Hospital

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