The project will consist of two studies. One study will explore the satiating properties of dairy cheese and its dairy-free substitute when consumed ad libidum, and another study will investigate their effects on postprandial glycemia. Both studies will involve healthy young adults. The secondary outcomes of these studies will be food sensory characteristics, diet-induced thermogenesis, subjective feeling of fatigue and energy, gastrointestinal comfort level, and food intake. The proposed project results will help to better understand the health properties of the cheese and its dairy-free substitute.

Start Date04 Aug 2024

Sponsor / Collaborator

Mount Saint Vincent University

[+1]

NCT05113641

/ RecruitingNot ApplicableIIT

Reducing Dietary Acid With Fruit and Vegetables Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD) Feasibility Trial

Metabolic acidosis is a common problem that occurs with worsening chronic kidney disease. Dietary acid can build up when the kidneys are not working well. This can be associated with a higher risk of worsening kidney function and death. The usual treatment is a medication called sodium bicarbonate which works to balance the acids in the body. The medication however often does not work and causes side effects. Consumption of alkalizing fruit and vegetables may work as a treatment for metabolic acidosis. This trial is being done to see if fruit and vegetables, provided via home delivery, can become a viable management for metabolic acidosis in patients with chronic kidney disease.

Start Date04 Aug 2023

Sponsor / Collaborator

University of Manitoba

[+2]

NCT05400694

/ CompletedNot ApplicableIIT

The Sensory and Metabolic Effects of Functional and Value-Added Dairy Products

Milk proteins possess multiple biological activities including their effect on blood glucose control, satiety and energy intake. The design of functional food products with added milk protein fractions has many challenges related to their inferior sensory properties. Chocolate milk presents the universal vehicle for added milk protein fractions that might partially mask their sensory characteristics. However, commercially produced chocolate milk has a significant amount of added sugar. This project will investigate the properties of a value-added dairy product (chocolate milk with reduced sugar content) enriched with individual milk protein fractions on characteristics of blood glucose control, satiety and energy intake in young healthy adults.

Start Date01 Oct 2021

Sponsor / Collaborator

Mount Saint Vincent University

[+1]

100 Clinical Results associated with Mount Saint Vincent University

0 Patents (Medical) associated with Mount Saint Vincent University

1,979

Literatures (Medical) associated with Mount Saint Vincent University

01 Jun 2025·Social Science & Medicine

Measurement invariance and differential item functioning of a care staff proxy measure of nursing home resident dementia-specific quality of life (DEMQOL-CH): do care aides' first language, and care aides' and residents’ ethno-cultural background matter?

Article

Author: Banerjee, Sube ; Kilmen, Sevilay ; Hoben, Matthias ; Estabrooks, Carole A ; O'Rourke, Hannah M ; Keefe, Janice

Quality of life (QoL) is a priority goal of dementia care, but measuring QoL becomes increasingly difficult as a person's ability to self-report declines. QoL measurement is particularly challenging among Nursing home (NH) residents, due to their often advanced cognitive impairment. The DEMQOL-CH is a validated tool to assess NH residents' QoL, using care staff proxy reports. Care staff and residents often have diverse ethno-cultural backgrounds, which may affect the measurement of QoL. Our objective was to assess measurement invariance and differential item functioning (DIF) of the DEMQOL-CH based on care staff ethno-cultural background, language, and resident ethno-cultural background. In a convenience sample of 9 NHs in the Canadian province of Alberta, research assistants conducted structured interviews with 119 care staff between July and September 2021 to complete DEMQOL-CH assessments of 612 residents. We performed confirmatory factor analyses, multiple group item response theory analyses, and DIF analyses. Measurement of the overall DEMQOL-CH score was affected by care staff ethno-cultural background and language (lack of scalar measurement invariance), but not by resident ethno-cultural background. Six of the 31 DEMQOL-CH items had DIF based on both, care staff ethno-cultural background and language, 2 items had DIF based on care staff ethno-cultural background, 4 items had DIF based on care staff language. Resident ethno-cultural background did not lead to DIF. The lack of measurement invariance and the presence of DIF affects the comparability of DEMQOL-CH assessments collected from care staff with diverse ethno-cultural and/or language backgrounds. However, the extent of the issues identified is small and the tool's other psychometric properties are robust. Therefore, we suggest that it is reasonable to continue to use the DEMQOL-CH in its current form, with careful consideration of methods to deal with and adjust for measurement invariance.

01 May 2025·Talanta

A sensitive electrochemical DNA biosensor for detecting the genome of a plant growth-promoting bacteria

Article

Author: Zahrebelnei, Felipe ; Etto, Rafael Mazer ; Carmo, Taiza Alissul Sauer do ; Urrea-Valencia, Salomé ; Gryczak, Derik William ; de Lara, Lucas Stori ; Lima, Dhésmon ; Wohnrath, Karen ; Galvão, Carolina Weigert ; Pessôa, Christiana Andrade

The challenge of increasing food production while maintaining environmental sustainability can be addressed by using biofertilizers such as Azospirillum, which can enhance plant growth and colonize more than 100 plant species. The success of this biotechnology depends on the amount of plant growth-promoting bacteria associated with the plant during crop development. However, monitoring bacterial population dynamics after inoculation requires time-consuming, laborious, and costly procedures. To address these issues, this study describes an effective electrochemical DNA biosensor to detect Azospirillum brasilense. The biosensor comprises a glassy carbon electrode modified with a nanocomposite based on carbon nanotubes and gold nanoparticles capped with 3-n-propylpyridinium chloride silsesquioxane, followed by the immobilization of a thiolated probe oligonucleotide that binds specifically to the A. brasilense genome (AZO_genome). The nanocomposite was characterized utilizing spectroscopic and morphological methods. Its presence on the biosensor's surface enhanced electrochemical responses due to its excellent electrocatalytic properties, as observed during electrochemical impedance spectroscopy and cyclic voltammetry experiments. The biosensor enabled the detection of AZO_genome after the hybridization event, which alters the electrochemical response of the electrode and was rapidly detected by square wave voltammetry. The detection range of the bacterial genome was 1.17 pmol L^-1 to 146.8 pmol L^-1, with LOD and LOQ of 0.261 and 0.322 pmol L^-1, respectively, and sensitivity of -15.560 μA/log [AZO_genome] (pmol L^-1). The biosensor showed good selectivity and reproducibility, with a coefficient of variation of -5.69 %, in addition to satisfactory sensitivity and stability for up to seven weeks. These promising analytical features allowed the quantification of A. brasilense in low concentrations in soil metagenomic DNA samples.

01 May 2025·Geriatric Nursing

The effects of relaxation interventions on physical and psychological distress among informal cancer caregivers: A systematic review

Article

Author: Chen, Chunfang ; Xu, Tuzhen ; Rose, Gloria M ; Liu, Caiyi

OBJECTIVESTo evaluate the effects of relaxation interventions on physical and psychological distress in informal cancer caregivers and identify effective intervention components.METHODSA systematic review was conducted. PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL Complete, Nursing & Allied Health Premium, Scopus, WHO International Clinical Trial Registry Platform, and PsycINFO were searched from January 1, 2010, to March 31, 2024. Risk of bias was conducted using the Mixed Methods Appraisal Tool.RESULTSWe identified a diverse range of relaxation interventions including aerobic exercise, back massage, music therapy, art therapy, mindfulness meditation, and progressive muscle relaxation, demonstrating reduced caregiver burden, anxiety, and stress levels while improving sleep quality and overall quality of life. However, studies were limited by short follow-up periods and methodological diversity.CONCLUSIONRelaxation interventions show promise in alleviating distress among cancer caregivers. Future studies should focus on optimizing intervention components and extending follow-up durations.

100 Deals associated with Mount Saint Vincent University

100 Translational Medicine associated with Mount Saint Vincent University

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