BGI Research

SHENZHEN, China, Nov. 22, 2024 /PRNewswire/ -- The 19th Annual Meeting of the International Conference on Genomics (ICG-19) officially opened at BGI Group's Global Headquarters in Shenzhen. This annual event brings together over 100 leaders in the field of genomics from the U.S., UK, Denmark, Australia, Singapore, and China amongst others to discuss the latest advancements in global life sciences. Continue Reading Professor Huanming Yang, Co-Founder of BGI Group, delivered a keynote address on milestones in genomics This year's conference builds on a strong legacy of fostering collaboration and innovation in the life sciences. Over the past 18 years, the conference has brought together more than 1,500 scientists, including Nobel Laureates, and has reached a global audience of over 15 million. The opening day emphasized the critical importance of harnessing genomics to address some of humanity's most urgent issues. Several speakers shared their insights on the transformative role of genomics in tackling global challenges such as aging, public health, and biodiversity conservation. In the opening speech, Dr. Siqi Liu, Chair of the ICG-19 Academic Committee, Co-founder and Member of the Board of Directors of BGI Group, and Chairman of the Supervisory Board of BGI Group, reflected on the history of the ICG. He underscored BGI's mission to go beyond research by focusing on advancing the application of genomics in industrial and medical fields. Professor Huanming Yang, Chair of the ICG-19 Organizing Committee, Co-founder and Member of the Board of Directors of BGI Group, and Director-General of BGI, reflected on key milestones in genomics, emphasizing ethical considerations, open data access, and global collaboration. His speech explored transformative technologies such as single-cell transcriptomics and AI-driven sequencing, highlighting their applications in life sciences. The four-day conference features a comprehensive program of talks on topics such as biodiversity, metagenomics and chronic diseases, frontiers in life sciences and bioinformatics, public health, population genetics and precision medicine, gene editing and biomanufacturing, and science for youth. During the conference, the global data analytics company Clarivate honored several distinguished individuals named in the 2024 "Highly Cited Researchers" list. The honorees included Professor Huanming Yang, Co-founder and Member of the Board of Directors of BGI Group; Dr. Xun Xu, Executive Director of BGI Group and Director of BGI-Research; Professor Karsten Kristiansen, Member of the Danish Academy of Natural Sciences and Professor at the University of Copenhagen; and Jinmiao Chen, Associate Professor at Duke-NUS Medical School. SOURCE BGI Group WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

A team of researchers has reported for the first time the live birth of a monkey that contains a high proportion of cells derived from a monkey stem cell line. This 'chimeric' monkey is composed of cells that originate from two genetically distinct embryos of the same species of monkey. This has previously been demonstrated in rats and mice but, until now, has not been possible in other species, including non-human primates. A team of researchers in China has reported for the first time the live birth of a monkey that contains a high proportion of cells derived from a monkey stem cell line. This "chimeric" monkey is composed of cells that originate from two genetically distinct embryos of the same species of monkey. This has previously been demonstrated in rats and mice but, until now, has not been possible in other species, including non-human primates. The details of the research are reported November 9 in the journal Cell. "This is a long-sought goal in the field," says senior author Zhen Liu of the Chinese Academy of Sciences (CAS). "This research not only has implications for understanding naive pluripotency in other primates, including humans, but it also has relevant practical implications for genetic engineering and species conservation. Specifically, this work could help us to generate more precise monkey models for studying neurological diseases as well as for other biomedicine studies." The monkeys used in the study were cynomolgus monkeys, also known as crab-eating or long-tailed macaques, a primate common in biomedical research. The investigators first established nine stem cell lines using cells removed from 7-day-old blastocyst embryos. They then placed the cell lines in culture to give them enhanced ability to differentiate into different cell types. They performed a number of different tests on the cells to confirm that they were pluripotent -- having the ability to differentiate into all of the cell types needed to create a live animal. The stem cells were also labeled with green fluorescent protein so the researchers would be able to determine which tissues had grown out of the stem cells in any animals that developed and survived. Ultimately, they selected a particular subset of stem cells to inject into early monkey morula embryos (embryos that are 4-5 days old). The embryos were implanted into female macaques, resulting in 12 pregnancies and six live births. Analysis confirmed that one monkey that was born alive and one fetus that was miscarried were substantially chimeric, containing cells that grew out of the stem cells throughout their bodies. Both were male. The investigators used the green fluorescent protein label to determine which tissues contained cells derived from the injected stem cells. They also used gene sequencing and other tests to confirm the presence of stem-cell-derived tissue across different organs. The tissue types they tested that contained the stem-cell-derived cells included the brain, heart, kidney, liver, and gastrointestinal tract. In the live monkey, the contribution of the stem cells in the different tissue types ranged from 21% to 92%, with an average of 67% across the 26 different types of tissue that were tested. The numbers were lower in the monkey fetus. In both animals, they also confirmed the presence of stem-cell-derived cells in the testes and in cells that eventually develop into sperm cells. "In this study, we have provided strong evidence that naive monkey pluripotent stem cells possess the capability of differentiating in vivo into all the various tissues composing a monkey body," says co-corresponding author Miguel Esteban of BGI Research and CAS. "This study deepens our understanding of the developmental potential of pluripotent stem cells in primate species." "This work helps us to better understand naive pluripotency in primate cells," adds co-corresponding author Qiang Sun of CAS. "In the future, we will try to increase the efficiency of this method for generating chimeric monkeys by optimizing the culture conditions for the stem cells, the cultures for the blastocysts where the stem cells are inserted, or both." The investigators also plan to further explore the mechanisms that underlie the survival of the embryos in the host animals, which they say will help improve the efficiency of chimera generation. This work was funded by the National Key Research and Development Program of China, the National Natural Science Foundation of China, the Shanghai Municipal Science and Technology Major Project, the Strategic Priority Research Program of the Chinese Academy of Sciences, the Basic Frontier Scientific Research Program of Chinese Academy of Sciences, the National Science and Technology Innovation 2030 Major Program, and Shenzhen Basic Research Project for Excellent Young Scholars.