Multicenter cohort research evaluating the effectiveness and safety of SGLT-2 inhibitor and DPP-4 inhibitor and metformin combined therapy in type 2 diabetes mellitus based on real-world study

Start Date30 Sep 2024

Sponsor / Collaborator

Guangzhou Integrative Medicine Hospital

ChiCTR2400080630

/ SuspendedNot Applicable

The mechanism and clinical empirical study of the regulation of ITA-GATA3 signaling pathway by auricular vagus nerve stimulation in the treatment of chronic insomnia comorbidities dyspepsia in the elderly

Start Date01 Jun 2024

Sponsor / Collaborator

Guangzhou Integrative Medicine Hospital

100 Clinical Results associated with Guangzhou Integrative Medicine Hospital

0 Patents (Medical) associated with Guangzhou Integrative Medicine Hospital

Literatures (Medical) associated with Guangzhou Integrative Medicine Hospital

01 Jan 2019·Caries ResearchQ2 · MEDICINE

A Membrane-Targeted Peptide Inhibiting PtxA of Phosphotransferase System Blocks Streptococcus mutans

Q2 · MEDICINE

Article

Author: Xiang, Shao-Wen ; He, Jian ; Shao, Jun ; Zhao, Wang-Hong ; Wu, Xin-Yu ; Xu, Xiao-Hu

Streptococcus mutans, the primary cause of dental caries, takes up carbohydrates through the phosphoenolpyruvate sugar phosphotransferase system (PTS). This study aimed to identify a novel membrane-targeted antimicrobial peptide (AMP) that could also target the L-ascorbate-specific PtxA component of the S. mutans PTS system. C10-KKWW was identified and selected using virtual screening of a lipopeptide library, a minimum inhibiting concentration (MIC) assay, cytotoxicity assays and a hemolysis assay. Surface plasmon resonance confirmed that C10-KKWW had a high binding affinity for PtxA. Combining with scanning electron microscopy and cell permeability assay, it was shown that the effects of C10-KKWW could be attributed to both membrane and PtxA. Wild type (WT) S. mutans, a ptxA deletion mutant (ΔptxA), and a mutant-complemented strain (CptxA), were cultured consistently in brain heart infusion (BHI) medium, tryptone-vitamin medium supplemented with 15 mM L-ascorbate (TVL), or for 5 h in BHI supplemented with 7.4 mM sodium L-ascorbate. Compared to ∆ptxA, in WT S. mutans and CptxA, C10-KKWW had a stronger MIC (3.9 μg/mL), and distinctively decreased biofilm viability. The extracellular concentrations of L-ascorbate/sodium L-ascorbate were not changed before and after WT treated with C10-KKWW. L-ascorbate-induced operon genes, or other PTS genes, were significantly suppressed by C10-KKWW. In conclusion, C10-KKWW has been developed; it acts through interaction with the bacterial membrane and interferes with L-ascorbate translocation to inhibit S. mutans growth and eradicate its biofilm. C10-KKWW may be especially effective at optimal oral ascorbate levels. A combination of C10-KKWW with sodium L-ascorbate might also be a novel strategy for dental caries treatment.

Buildings

Sick Building Syndrome: Prevalence and Risk Factors Among Medical Staff in Chinese Hospitals

Author: Huang, Fuyuan ; Ying, Xiaoyu ; Tan, Yang ; Lin, Jingkai ; Wang, Qianling ; Weng, Jiantao ; Sun, Yukai

Sick building syndrome (SBS) poses a significant challenge in hospital settings, adversely affecting staff health, operational efficiency, and environmental quality. This study aims to investigate the prevalence and risk factors of SBS among medical staff in Chinese hospitals, advancing the literature by pinpointing actionable environmental and psychological factors tailored to this occupational group within China’s distinct regional context. A survey questionnaire was administered to 615 medical staff members across seven private hospitals located in the eastern coastal region of China. Data were collected using structured questionnaires. The survey encompassed 27 factors across four aspects, with respondents being asked to self-assess the severity of four types of SBS symptoms (never, rarely, occasionally, often). Multivariable binary logistic regression analysis was carried out to identify factors associated with SBS, based on odds ratios (OR) with a significance level of p < 0.05. The prevalence rates for skin symptoms, mucosal symptoms, and general symptoms were 32.8%, 61%, and 71.1%, respectively. Gender, psychological mood, visibility of water systems and greenery from the workspace, outdoor noise environment, indoor air quality, indoor natural lighting, department of occupancy, design of workspace, cleanliness, and control over the indoor environment (temperature, lighting) were identified as risk factors related to SBS symptoms. These findings underscore the critical role of modifiable building design and psychological factors in SBS occurrence, offering a novel perspective on hospital-specific risks in China compared to global studies. Enhancing indoor and outdoor environments—through increased greenery, noise reduction, improved air quality, better lighting, and greater environmental control—emerges as a vital strategy to mitigate SBS, with implications for hospital management and staff well-being.

Frontiers in Medicine

Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature

Author: Yang, Lin ; Pan, Wenjue ; Wei, Xinzheng ; Qian, Ying ; Zhao, Xiujie ; Xiao, Haowen ; Qian, Zijun ; Meng, Huimin

Extramedullary multiple myeloma (EMM) is an aggressive sub-entity of multiple myeloma (MM). Despite an excellent improvement in survival for most patients with MM over recent decades, the overall survival (OS) of patients with EMM was usually not longer than 3 years. Standard treatment for patients with EMM has not been established, and their management is particularly challenging. We presented a heavily pretreated young patient with relapsed EMM and refractoriness to a proteasome inhibitor (PI; bortezomib), a next-generation PI (ixazomib), immunomodulatory drugs (IMiDs; lenalidomide), autologous hematopoietic stem cell transplantation (ASCT), and monoclonal antibody (directed against CD38: daratumumab) and indicated that myeloablative haploidentical hematopoietic stem cell transplantation (haploidentical-HSCT) as a salvage treatment of relapse after a chimeric antigen receptor (CAR)-T cell therapy that targeted B-cell maturation antigen (BCMA) (NCT04650724) is feasible. Taken together of the contemporary literature, the promising results on the effect of anti-BCMA CAR-T cell therapy and allogeneic HSCT might present a proof-of-principle for patients with EMM, and therefore, patients with the disease need to be included in future studies.

100 Deals associated with Guangzhou Integrative Medicine Hospital

100 Translational Medicine associated with Guangzhou Integrative Medicine Hospital

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