Delving into the Latest Updates on Arula Tibetan Medicine Group Co., Ltd. with Synapse

Overview

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Congenital Disorders

Endocrinology and Metabolic Disease

Skin and Musculoskeletal Diseases

Herbal medicine

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Disease Domain	Count

Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Herbal medicine	1

ETHNOPHARMACOLOGICAL RELEVANCEGout, a painful joint disease with a prevalence ranging from 0.86% to 2.2% in China over the past decade. Traditional medicine has long utilized the medicinal and edible Piper longum L. (PL) fruit spikes for treating gout and other joint conditions like rheumatoid arthritis. However, the exact mechanisms behind its effectiveness remain unclear.AIM OF THE STUDYThis study aimed to investigate the potential of alcoholic extracts from PL fruit spikes as a safe and effective treatment for gout. We used a combined network pharmacology and experimental validation approach to evaluate the mechanisms behind the anti-gout properties of PL.MATERIALS AND METHODSUPLC-Q/TOF-MS analysis determined the major components of PL. Subsequently, network pharmacology analysis predicted potential molecular targets and related signaling pathways for the anti-gout activity of PL. Molecular docking simulations further explored the interactions between PL compounds and proteins and characterized the properties of potential bioactive secondary metabolites. Mouse models of air pouch inflammation and hyperuricemia were further established, and the anti-gout mechanism of PL was confirmed by examining the expression of proteins related to the MAPK and PI3K-AKT pathways in the tissue.RESULTSOur analysis revealed 220 bioactive secondary metabolites within PL extracts. Network pharmacology and molecular docking results indicated that these metabolites primarily combat gout by modulating the PI3K-AKT and MAPK signaling pathways. In vivo experiments have also proven that PL at a dose of 100 mg/kg can optimally reduce acute inflammation of gout and kidney damage caused by high uric acid. The anti-gout mechanism involves the PI3K-AKT/MAPK signaling pathway and its downstream NF-κB pathway.CONCLUSIONThis study provides compelling evidence for PL's therapeutic potential in gout management by modulating key inflammatory pathways. The findings offer a strong foundation for future clinical exploration of PL as a gout treatment option.

17 Feb 2024·International Journal of Food Sciences and Nutrition

Alterations in the sequence and bioactivity of food-derived oligopeptides during simulated gastrointestinal digestion and absorption: a review

Review

Author: Liu, Wanlu ; Li, Kexin ; Yu, Shengjuan ; Liu, Xinqi ; Li, He ; Wang, Zhen

Food-derived oligopeptides (FOPs) exhibit various bioactivities. However, little was known about their sequence changes in the gastrointestinal tract and the effect of changes on bioactivities. FOPs' sequence features, changes and effects on bioactivities have been summarised. The sequence length of FOPs decreases with increased exposure of hydrophobic and basic amino acids at the terminal during simulated gastrointestinal digestion. A decrease in bioactivities after simulated intestinal absorption has correlated with a decrease of Leu, Ile, Arg, Tyr, Gln and Pro. The sequence of FOPs that pass readily through the intestinal epithelium corresponds to transport modes, and FOPs whose sequences remain unchanged after transport are the most bioactive. These include mainly dipeptides to tetrapeptides, consisting of numerous hydrophobic and basic amino acids, found mostly at the end of the peptide chain, especially at the C-terminal. This review aims to provide a foundation for applications of FOPs in nutritional supplements and functional foods.

Shipin Yu Yaopin

Determination of Polysaccharide in Shoushen Shenbao Capsules by DNS Method

Author: Li Huai-ping ; Sun Yue-ning ; Liu You-ju ; Luo Ming-ying

Objective To establish a method for the determination of polysaccharide in Tibetan medicine Shoushen Shenbao to better control the quality of Shoushen Shenbao Capsules.Methods The content of polysaccharide in Shoushen Shenbao Capsules was determined by spectrophotometry after chromogenic reaction with 3,5-dinitrosalicylic acid(DNS).Results The absorbance of the sample was determined at 520 nm after chromogenic reaction with DNS.There was a good linear relationship between the absorbance of the solution and the glucose content, and the linear range was 8.597-42.984 μg/mL.The regression equation was A=0.01839 C+0.01030, r=0.9981.The average recovery was 98.37 %, with RSD of 1.57 %(n=6).The polysaccharide contents of 3 batches of samples were 103.03-105.03 mg/capsule calculated as glucose.Conclusion This method is simple, accurate, controllable and reproducible, which can provide scienti?c basis for quality control of Shoushen Shenbao Capsules.

100 Deals associated with Arula Tibetan Medicine Group Co., Ltd.

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100 Translational Medicine associated with Arula Tibetan Medicine Group Co., Ltd.

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Pipeline

Pipeline Snapshot as of 26 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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