Yangtze River Pharmaceutical Group Guangzhou Hairui Pharmaceutical Co., Ltd.

Main purpose: To evaluate the effectiveness and safety of Zhengyuan capsule in the treatment of chemotherapy-related cancer-related fatigue; Secondary purpose: To evaluate the effect of Zhengyuan capsule on the quality of life of patients; To explore the relationship between immune function indicators, neuroendocrine function indicators, cancer-related fatigue and Zhengyuan capsule.

Primary objective: To study the pharmacokinetic behavior of the test formulation of amlodipine benazepril capsules (specifications: amlodipine 5mg; benazepril hydrochloride 10mg, Yangtze River Pharmaceutical Group Guangzhou Hairui Pharmaceutical Co., Ltd.) and the reference formulation (trade name: Lotrel, specifications: amlodipine 5mg; benazepril hydrochloride 10mg, Novartis Pharmaceuticals Corporation) in healthy subjects after a single oral administration in fasting and postprandial states, and to evaluate the bioequivalence of the two formulations; Secondary objective: To observe the safety of the test formulation and the reference formulation (trade name: Lotrel) in healthy subjects.

To compare the pharmacokinetic characteristics of a single oral dose of clopidogrel bisulfate tablets (75 mg) produced by Guangzhou Hairui Pharmaceutical Co., Ltd. of Yangtze River Pharmaceutical Group and clopidogrel bisulfate tablets (trade name: Plavix, 75 mg) produced by Sanofi Winthrop Industrie, France and packaged by Sanofi (Hangzhou) Pharmaceutical Co., Ltd. in healthy adults under fasting state, and to evaluate the bioequivalence and safety of the two preparations.