Chronic insomnia affects 5-10% of adults in developed countries, often associated with stress and mental health challenges.Traditional pharmacol. interventions frequently present side effects, motivating research into alternative stress and sleep management strategies.This clin. trial investigated the safety and efficacy of a novel phytoconstituent-based gummy supplement in reducing stress and improving sleep quality.An open-label, single-arm clin. study was conducted with 30 healthy volunteers (15 males, 15 females).The investigational product contained extracts of Withania somnifera, L-Theanine, Matricaria chamomilla, and Crocus sativus.Participants consumed two destress and snooze gummies daily, 30 min before bed for 30 days.Participants were evaluated using the Perceived Stress Scale (PSS) and Insomnia Severity Index (ISI).Comprehensive hematol., biochem., and vital sign assessments were performed at screening and after 30 days of intervention.The study demonstrated statistically significant improvements: 47.84% reduction in perceived stress and 38.38% decrease in insomnia severity.Most blood parameters remained stable, with a notable decrease in creatinine levels.Only 4 participants (13.33%) experienced mild adverse events unrelated to the investigational product.The phytoconstituent-based gummies proved safe and effective in managing stress and improving sleep quality.The formulation's safety, tolerability, and potential efficacy make it an intriguing option for further investigation and potential integration into holistic stress and sleep management strategies.