Bharat Biotech International Ltd.

Sept. 10, 2024 -- Alopexx, Inc., a clinical-stage biotechnology company focused on developing novel, broad-spectrum immune-mediated therapeutics for the prevention and treatment of bacterial, fungal, and parasitic infections, today announced a collaboration with Bharat Biotech for the co-development and commercialization of Alopexx’s proprietary broad-spectrum anti-microbial vaccine, AV0328, in India and other low income and lower middle-income countries. Bharat Biotech is a pioneering biotechnology company known for its world-class research and development and manufacturing capabilities. As part of the collaboration, the companies will co-develop and commercialize AV0328, a synthetic vaccine targeting poly N-acetyl glucosamine (PNAG), in India and other licensed territories. Alopexx would be entitled to a one-time upfront payment and milestone payments, as well as royalties on future sales of AV0328 in the licensed territories. “We are excited to enter into this collaboration with Bharat Biotech,” said Dr. Daniel Vlock, CEO of Alopexx. “To partner with a company with such vast experience and expertise in vaccine development is a significant validation of the value and potential of Alopexx’s technology. This collaboration brings us one step closer to addressing the critical need for affordable, broad-spectrum antimicrobial solutions, especially in low-and middle-income countries.” Dr. Vlock added, “We also deeply appreciate the collaborative support provided by Bharat Biotech. This support is not only crucial for the advancement of AV0328, but will also significantly bolster our overall clinical programs. The broad and breakthrough potential of our platforms in treating a wide array of bacterial, fungal, and parasitic infections represents a transformative approach to combating infectious diseases on a global scale.” Dr. Krishna Ella, Executive Chairman of Bharat Biotech, commented, “We are proud to collaborate with Alopexx to bring AV0328 to the regions where it is most needed. Our goal is to develop solutions to reduce anti-microbial resistance through vaccination. This collaboration aligns with our mission to provide safe, affordable, and high-quality vaccines to combat infectious diseases globally.” AV0328 is a synthetic vaccine designed to target poly N-acetyl glucosamine (PNAG), a substance found on the surface of a wide range of bacterial, fungal, and parasitic pathogens. In pre-clinical studies, targeting PNAG has shown effectiveness in preventing and treating infections caused by over 15 different pathogens. A phase I, first-in-human trial has been completed, demonstrating that AV0328 is well-tolerated with no serious adverse events observed. The vaccine induced antibodies capable of killing a wide range of PNAG-expressing pathogens, reaffirming its potential as a broad-spectrum antimicrobial solution. Bharat Biotech (BBIL) is a biotech company in Genome Valley, Hyderabad, India. BBIL is a global leader with 145 patents, ~20 vaccines and bio-therapeutics, and registrations in 125 countries. These vaccines were developed through clinical trials in more than 20 countries worldwide and have been published in more than 100 peer-reviewed journals. The company has manufactured and supplied more than 9 billion doses of vaccines globally, saving millions of lives and livelihoods annually. The company has world-class vaccine and bio-therapeutics research, product development, manufacturing, and distribution facilities. BBIL has developed vaccines for infectious diseases, including Hepatitis B, Pentavalent (DPT+HepB+Hib), Rabies, Typhoid, polio, H1N1 influenza, Japanese Encephalitis (JENVAC®), India’s first Rotavirus vaccine, the world’s first Typhoid conjugate vaccine, TYPBAR TCV®, novel vaccines for COVID-19 such as COVAXIN® and INCOVACC®. BBIL introduced WHO pre-qualified vaccines, namely BIOPOLIO®, ROTAVAC®, ROTAVAC 5D®, and TYPBAR TCV®, in several countries worldwide. BBIL has a strong pipeline of innovative vaccines against malaria, tuberculosis, Para Typhi A, non-typhoidal salmonella, chikungunya, and Zika. The acquisition of Chiron Behring Vaccines has positioned Bharat Biotech as one of the world's largest rabies vaccine manufacturers with CHIRORAB® and INDIRAB®. To learn more about BBIL, visit www.bharatbiotech.com. Alopexx is a clinical-stage biotechnology company targeting novel immune therapeutics for the prevention and treatment of bacterial, fungal and parasitic microbial infections. The target of our therapeutics, poly N-acetyl glucosamine (PNAG), has been found in a wide range of pathogens. Our vaccine candidate, AV0328, has been shown to induce protective antibodies against a wide range of PNAG-expressing pathogens in a Phase I trial. F598, our fully human monoclonal antibody, has been shown to be safe and well tolerated in phase I and pilot trials. Following a single infusion, it can provide protection for 2-3 months. Our goal is to develop a broad-spectrum, non-antibiotic therapeutic platform for the treatment and prevention of microbial infections. These immune therapeutics will reduce reliance on antibiotics and the development of antimicrobial resistance. For more information, please visit www.Alopexx.com. The content above comes from the network. if any infringement, please contact us to modify.

Sanofi's flu vaccine manufacturing hiccup in China, DualityBio's proposed Hong Kong IPO and UCB's $680 million sale of some Chinese assets made our news this week. Sanofi has suspended distribution of its two flu vaccines in China out of concern of waning potency. BioNTech's antibody-drug conjugate partner, DualityBio, has filed for a Hong Kong IPO. UCB will offload some Chinese assets for $680 million. And more.1. Sanofi halts flu vaccine distribution in China over fear of declining potencySanofi has temporarily stopped selling its two flu vaccines, Vaxigrip and VaxigripTetra, in China after a routine quality follow-up test flagged a decline in the vaccines’ potency in doses that were not yet distributed. The company attributed the problem to “unexpected circumstances” at the company’s production line in Shenzhen, China, which supplies doses only for the Chinese market.2. Duality plans Hong Kong IPO to fund trials of BioNTech-partnered ADCs and beyondChina’s Duality Biotherapeutics has filed for a Hong Kong IPO. The antibody-drug conjugate specialist set up shop in 2019 and has attracted deals with BioNTech, BeiGene and Adcendo that could be worth more than $4 billion combined. Duality named BioNTech-partnered ADCs targeting HER2 and B7-H3 as its “core products,” with the HER2 program nearing a potential application for accelerated approval in 2025.3. UCB sells off production plant and a clutch of older meds in China for $680MAnother foreign company is trimming its business in China. UCB is selling off its mature neurology and allergy brands in mainland China, plus a manufacturing site in the Chinese city of Zhuhai, to investment shops CBC Group and Mubadala for $680 million. The Belgian company will instead explore the launch of novel medicines in immunology, neurology and rare diseases in China, UCB CEO Jean-Christophe Tellier said.4. FDA weighs limiting PD-1 drugs in stomach cancer, calls on experts to discuss Merck, BMS and BeiGene medsThe FDA will hold an advisory committee meeting to discuss whether approvals for PD-1 inhibitors in advanced gastric and gastroesophageal junction adenocarcinoma and esophageal squamous cell carcinoma should be restricted based on tumors’ PD-L1 expression. BeiGene’s two open applications for Tevimbra, plus existing approvals for Merck’s Keytruda and Bristol Myers Squibb’s Opdivo, will be examined closely.5. As sales climb, Jazz's Epidiolex falls short in Japanese study in treatment-resistant epilepsiesA phase 3 Japanese study of Jazz Pharma’s cannabinoid drug Epidiolex has failed on the primary endpoint measuring seizure frequency in certain patients with treatment-resistant epilepsies. Still, the company pointed to numeric improvements across primary and secondary endpoints, as well as the drug’s overall global data, saying it plans to speak with Japanese authorities about a potential filing.6. Ipsen sues CSPC Pharma to block rival to cancer drug Onivyde (Bloomberg Law)Ipsen has filed a patent infringement lawsuit against China’s CSPC Pharma. The lawsuit centers on Ipsen’s Onivyde, a liposome formulation of the chemotherapy irinotecan, and CSPC’s irinotecan liposome candidate, which was filed with the FDA in late 2023 for previously treated pancreatic cancer. Ipsen alleges that CSPC steps on its new patent, which was issued Aug. 13, according to the complaint (PDF).Other News of Note:7. Bora's expansion tear continues as CDMO takes up stake in Tanvex, gains manufacturing capabilities8. With new focus, Kyowa Kirin pulls decades-old breast cancer drug Fareston from US market9. Bharat Biotech to launch oral cholera vaccine developed in partnership with Hilleman Labs (release)10. Tech company Fujitsu partners with Paradigm Health to boost clinical trials in Japan11. YolTech sells China rights to cholesterol gene editing therapy to Salubris for $29M12. API maker Global Calcium stung with Form 483 filing after FDA inspection of Indian plant

The rising demand for vaccine adjuvants is mainly due to the increasing rates of infectious and cancerous diseases. Other significant factors include the heightened need for vaccines for specific illnesses, a greater emphasis on immunization, and the expansion of vaccination programs globally. This trend is projected to persist through the forecast period from 2024 to 2030. LAS VEGAS, Aug. 29, 2024 /PRNewswire/ -- DelveInsight's Vaccine Adjuvants Market Insights report provides the current and forecast market analysis, individual leading vaccine adjuvants companies' market shares, challenges, vaccine adjuvants market drivers, barriers, trends, and key market vaccine adjuvants companies in the market. Key Takeaways from the Vaccine Adjuvants Market Report As per DelveInsight estimates, North America is anticipated to dominate the global vaccine adjuvants market during the forecast period. In the product segment of the vaccine adjuvants market, the oil-in-water emulsion category had a significant revenue share in the vaccine adjuvants Market in 2023. Notable vaccine adjuvants companies such as Dynavax Technologies, GSK plc, Croda International plc, SEPPIC, Novavax, SPI Pharma, Agenus Inc., Aurorium, Merck KGaA, Vaxine Pty Ltd., Hawaii Biotech Inc., CSL, OZ Biosciences, InvivoGen, Allergy Therapeutics, EUBIOLOGICS CO., LTD., Pacific GeneTech Limited, Riboxx GmbH, CaPtivate Pharmaceuticals LLC, Mukta Industries, and several others, are currently operating in the vaccine adjuvants market. In May 2023 Croda International Plc entered into a partnership with Amyris and Botanical Solutions Inc. firstly for biotechnology-derived squalene and secondly with BSI to develop a sustainable QS-21 vaccine adjuvant moving towards plant tissue culture-derived approach rather than the traditional method of extracting QS-21 from soap bark trees. In August 2022, GSK Plc entered into an acquisition with Affinivax, Inc. to develop pneumococcal vaccines. To read more about the latest highlights related to the vaccine adjuvants market, get a snapshot of the key highlights entailed in the Global Vaccine Adjuvants Market Report Vaccine Adjuvants Overview Vaccine adjuvants are substances added to vaccines to enhance the body's immune response to the primary antigen. By stimulating the immune system more effectively, adjuvants can reduce the amount of antigen required and increase the duration of immunity. They play a crucial role in improving the efficacy of vaccines, particularly in cases where the antigen alone might not provoke a strong enough immune reaction. Adjuvants can work through various mechanisms, such as promoting a stronger local immune response at the injection site or facilitating a more robust activation of immune cells. Common types of adjuvants include aluminum salts, which have been used for decades and are known for their safety and effectiveness in boosting antibody responses. More recently, newer adjuvants like oil-in-water emulsions and toll-like receptor agonists have been developed to target specific aspects of the immune system. Research continues to explore and refine adjuvants to enhance vaccine performance, aiming to provide better protection against a range of infectious diseases and improve vaccine responses in different populations, including the elderly and immunocompromised individuals. Vaccine Adjuvants Market Insights In 2023, North America is anticipated to represent the largest share of the vaccine adjuvants market among all regions. This growth is driven by several factors. The region benefits from a well-established healthcare infrastructure and strong research and development capabilities, which stimulate advancements in vaccine adjuvant technologies. Additionally, increasing cases of infectious diseases and the threat of potential pandemics, like influenza or new pathogens, have led to greater investment in vaccine and adjuvant research. Government efforts to expand vaccination programs and enhance public health preparedness are also contributing to market growth. For example, the US Department of Health and Human Services (HHS) launched the HPV VAX NOW campaign in January 2021 to boost HPV vaccination rates among young adults. Similarly, the Government of Canada released updated guidelines on seasonal influenza vaccines for 2022-2023 in August 2022, which is expected to further stimulate market growth. Moreover, market expansion is supported by strategies such as product approvals, launches, and agreements. In November 2022, GSK plc's RSV vaccine candidate for older adults received a priority review from the FDA, indicating significant advancements in treatment or prevention. The combined effect of increased government and nonprofit investment in adjuvant development, alongside various product development activities, is set to drive the North American vaccine adjuvants market throughout the forecast period. To know more about why North America is leading the market growth in the vaccine adjuvants market, get a snapshot of the Vaccine Adjuvants Market Outlook Vaccine Adjuvants Market Dynamics The vaccine adjuvants market is experiencing significant growth driven by i ncreasing vaccine development and the demand for enhanced vaccine efficacy. Adjuvants are critical in improving the immune response to vaccines, which is particularly important as new and more complex pathogens emerge. The surge in research and development efforts, especially following the COVID-19 pandemic, has accelerated the need for innovative adjuvant technologies. Companies are focusing on developing adjuvants that can enhance the effectiveness of vaccines with lower doses, thereby addressing both efficacy and cost concerns. Technological advancements are playing a crucial role in shaping the dynamics of the adjuvants market. The development of novel adjuvants, such as nanoparticle-based and recombinant protein adjuvants, is gaining traction. These new technologies offer improved safety profiles and better control over immune responses. Additionally, the rise of personalized medicine and targeted therapies is driving interest in adjuvants that can be tailored to individual patient needs, further expanding the market potential. The r egulatory landscape and approval processes for vaccine adjuvants are also influencing market dynamics. Stringent regulatory requirements and the need for extensive clinical trials can pose challenges for market entry and innovation. However, successful navigation of these regulatory hurdles can lead to significant rewards, as demonstrated by the successful adjuvants used in COVID-19 vaccines. Companies that can efficiently meet regulatory standards while delivering effective solutions are likely to gain a competitive edge. Moreover, the vaccine adjuvants market is witnessing increased investment and collaboration between pharmaceutical companies, academic institutions, and government agencies. This collaborative approach is essential for advancing research, sharing knowledge, and accelerating the development of new adjuvant technologies. The convergence of resources and expertise from multiple stakeholders is expected to drive innovation and expand the market further. Overall, the vaccine adjuvants market is poised for substantial growth due to technological advancements, rising demand for effective vaccines, and increased investment in research and development. As the global focus on public health and disease prevention continues to intensify, the role of adjuvants in enhancing vaccine efficacy will remain a critical component of the healthcare landscape. Get a sneak peek at the vaccine adjuvants market dynamics @ Vaccine Adjuvants Market Dynamics Analysis Vaccine Adjuvants Market Assessment Vaccine Adjuvants Market Segmentation Vaccine Adjuvants Market Segmentation By Product Type: Oil-In-Water Emulsion, Aluminium Salts, Liposomes, Saponin-Based Adjuvants, and Others Vaccine Adjuvants Market Segmentation By Disease Type: Infectious Diseases, Cancer, and Others Vaccine Adjuvants Market Segmentation By Geography: North America, Europe, Asia-Pacific, and Rest of World Porter's Five Forces Analysis, Product Profiles, Case Studies, KOL's Views, Analyst's View Which MedTech key players in the vaccine adjuvants market are set to emerge as the trendsetter explore @ Vaccine Adjuvants Companies Table of Contents Interested in knowing the vaccine adjuvants market by 2030? 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