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Neoplasms

Fusion protein

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Disease Domain	Count

Neoplasms	1

Top 5 Drug Type	Count

Fusion protein	1

Top 5 Target	Count

Telomerase	1

BackgroundEnterococcus faecalis (E. faecalis), the main pathogenic bacterium of root canal infection, can penetrate deep into the dentin tubule, form a biofilm, and resist host defense mechanisms, thereby increasing treatment complexity. Therefore, the key to the treatment of root canal infections is to completely kill the bacteria and prevent secondary infection. This review assesses advancements in traditional and novel disinfection methods targeting E. faecalis biofilm.MethodsBy comparing the bactericidal mechanisms and effects of the individual and combined application of these methods, the scientific basis and clinical application potential of these methods as adjuvant or alternative treatments were evaluated and the scientific basis for the optimization of the root canal treatment strategy was provided.ResultsEmerging strategies, including natural medicine, antibacterial photodynamic therapy, and cold atmospheric plasma, have shown promising antibacterial effects.ConclusionThese approaches have the potential to replace traditional disinfection methods, offering more effective solutions for clinical pulp treatment.

31 Dec 2025·Applied Mathematics in Science and Engineering

Improvements to Slater's inequality and their applications via functions whose fourth-order derivatives are convex

Author: Sohail, Asadullah ; Li, Yi-Xia ; Ullah, Hidayat ; Alnowibet, Khalid A. ; Chu, Yu-Ming ; Khan, Muhammad Adil

01 Oct 2025·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

A near-infrared fluorescence probe for sensing mitochondrial viscosity in cells and mice

Article

Author: Zhang, Xiao-Fan ; Cao, Xiao-Qun ; Shen, Shi-Li ; Zou, Han-Yang ; Shang, Jizhen ; Wang, Zhao-Chen ; Liu, Xiao-Hui ; Du, Yi-Fan

Mitochondria play a critical role in providing energy to maintain cellular physiological functions. The viscosity in mitochondria is one of the important indicators of mitochondrial microenvironment. When mitochondrial viscosity increases, it often indicates the occurrence or development of certain diseases. Herein, a series of near-infrared (NIR) fluorescent probes (ZHY-1 ∼ 4) were developed to detect viscosity changes. After screening, we selected ZHY-2 for cellular imaging, since it had the largest fluorescence intensity enhancement (222 times) in response to viscosity compared to the other probes (ZHY-1, ZHY-3, ZHY-4). In addition, ZHY-2 responded to viscosity specifically, and was not affected by pH and other biological species. Also, the probe ZHY-2 had good biocompatibility and mitochondria-targeting ability. It has been applied to measure viscosity changes after stimulation of nystatin and rapamycin. Finally, using probe ZHY-2, we have achieved the real-time fluorescence imaging of viscosity during starvation, as well as in drug-induced liver injury mice.

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100 Translational Medicine associated with Huzhou University

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Pipeline

Pipeline Snapshot as of 29 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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