University Hospital Hradec Kralove

This study investigated the effect of desflurane and propofol anesthesia on visual acuity in patients in prone position for spinal surgery. Many trials have investigated the effects of different anesthetic agents on intraocular pressure, propofol may reduce intraocular pressure more than other intravenous anesthetics.

The goal of this prospective observational study is to evaluate the role of ultrasound-guided tru-cut biopsy (in the hands of an expert certified sonographer within a gynecological center)in patients with suspected ovarian cancer.
The main questions it aims to answer are:
Is the material from tru-cut biopsy adequate for histopathological and immunohistochemical examination? Is the material accurate in comparison with the final pathological specimen? What are the patient experience and complications after the procedure?
Participants who will undergo a standard tru-cut biopsy procedure will need to additionally answer the questionnaire.

The goal of this monocentric double blinded cross over trial is to evaluate safety and tolerability of inhaled furosemide in patients with pulmonary diseases and dyspnea.
The main question[s] it aims to answer are:
is inhaled furosemide safe and well tolerated?
is inhaled furosemide capable of dyspnea suppression and is there any additive effect of levodropropizine
Participants will be given:
inhaled furosemide or placebo in double blinded cross over manner. Dyspnea severity and vital functions will be measured, adverse reactions monitored
all participants will receive levodropropizine open label. Dyspnea severity and vital functions will be measured, adverse reactions monitored