Last update 01 Nov 2024

IRAK3

Basic Info

Synonyms
IL-1 receptor-associated kinase M, Inactive IL-1 receptor-associated kinase 3, interleukin 1 receptor associated kinase 3
+ [4]
Introduction
Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383).

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