Synonyms 泡囊相关膜蛋白2, SYB2, synaptobrevin 2 + [5] |
Introduction Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) (PubMed:30929742). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. |
Target |
Mechanism VAMP1 inhibitors [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date08 Dec 2000 |
Target |
Mechanism VAMP1 modulators [+1] |
Active Org.- |
Originator Org. |
Active Indication- |
Inactive Indication |
Drug Highest PhaseDiscontinued |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date30 Nov 2023 |
Sponsor / Collaborator |
Start Date25 Nov 2023 |
Sponsor / Collaborator- |
Start Date16 Nov 2021 |
Sponsor / Collaborator |