Last update 08 May 2025

TRABD2A

Basic Info

Synonyms
C2orf89, Metalloprotease TIKI1, TIKI1
+ [3]
Introduction
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Analysis

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