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Last update 08 May 2025

EMR1

Last update 08 May 2025

Basic Info

Synonyms

ADGRE1, Adhesion G protein-coupled receptor E1, egf-like module containing, mucin-like, hormone receptor-like 1

+ [6]

Introduction

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Drugs associated with EMR1

Anti-EMR1 CAR-T cell therapy (Humanigen)

Target

EMR1

Mechanism

EMR1 inhibitors [+2]

Active Org.-

Originator Org.

Humanigen, Inc.

Active Indication-

Inactive Indication

Leukemia

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

HGEN-005

Target

EMR1

Mechanism

EMR1 inhibitors [+1]

Active Org.-

Originator Org.

Humanigen, Inc.

Active Indication-

Inactive Indication

Asthma [+3]

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with EMR1

100 Translational Medicine associated with EMR1

0 Patents (Medical) associated with EMR1

180

Literatures (Medical) associated with EMR1

01 May 2025·Journal of Clinical and Experimental Hepatology

Liver Organoids From Hepatocytes of Healthy Humans and Non-alcoholic Fatty Liver Disease (NAFLD) Patients Display Multilineage Architecture and can be Used to Develop an In Vitro Model of Steatohepatitis

Article

Author: Tandon, Ruchi ; Yadav, Rajni ; Sharma, Phulwanti K ; Goswami, Yamini ; Garg, Pramod K ; Biswas, Sagnik ; Shalimar ; Baghel, Akash ; Sharma, Ghanshyam

Background/AimNon-alcoholic fatty liver disease (NAFLD) is a global health concern with limited treatment options. The paucity of predictive i n v itro models in preclinical settings seems to be one of the limitations of identifying effective medicines. We therefore aimed to develop an i n v itro model that can display the key hallmarks of NAFLD, such as steatosis, inflammation, and fibrosis.MethodsAn in vitro model of steatohepatitis was developed using organoids prepared from hepatocytes of healthy individuals from a commercial source (HLOs) and the liver tissues collected from needle biopsies of NAFLD patients (HLO_NAFLD) using defined culture conditions. HLOs were treated with palmitic acid for 72 h to develop an i n v itro model of steatohepatitis, while HLO_NAFLD served as a natural model of steatohepatitis. Metformin and saroglitazar were used to validate the liver organoid model of steatohepatitis. Saroglitazar was also evaluated in the high-fat, high-fructose (HF-HF) diet-induced model of NAFLD using C57BL/6 mice to validate the findings from the i n v itro model.ResultsHLOs and HLO_NAFLD exhibited bipotent properties, showing the expression of markers of hepatocytes, ductal cells, and also stem cells. Furthermore, they demonstrated the expression of nonparenchymal cell markers such as stellate cells (CD166) and Kupffer-like cells (CD68 and EMR1). The steatohepatitis models developed using these organoids displayed markers associated with steatosis, inflammation and fibrosis, which were decreased by metformin and saroglitazar.ConclusionThe in vitro models developed in our lab employing HLOs and HLO_NAFLD display all three key hallmarks of NAFLD: steatosis, inflammation, and fibrosis without the necessity for coculture with other nonparenchymal cells. The implementation of the HLO_NAFLD-based model is also expected to provide a more realistic assessment of test substances to develop therapeutics for NAFLD.

01 Mar 2025·Nature Nanotechnology

Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology

Article

Author: Garcia-Cabau, Carla ; Krieg, Michael ; Sanfeliu-Cerdán, Neus ; Pezzano, Fabio ; Jiménez-Delgado, Senda ; Martínez-Fernández, Carmen ; Frigeri, Paolo-Antonio ; Ruprecht, Verena ; Català-Castro, Frederic ; Salvatella, Xavier ; Ortiz-Vásquez, Santiago ; Fernández-Campo, Martín

AbstractQuantifying the mechanical response of the biological milieu (such as the cell’s interior) and complex fluids (such as biomolecular condensates) would enable a better understanding of cellular differentiation and aging and accelerate drug discovery. Here we present time-shared optical tweezer microrheology to determine the frequency- and age-dependent viscoelastic properties of biological materials. Our approach involves splitting a single laser beam into two near-instantaneous time-shared optical traps to carry out simultaneous force and displacement measurements and quantify the mechanical properties ranging from millipascals to kilopascals across five decades of frequency. To create a practical and robust nanorheometer, we leverage both numerical and analytical models to analyse typical deviations from the ideal behaviour and offer solutions to account for these discrepancies. We demonstrate the versatility of the technique by measuring the liquid–solid phase transitions of MEC-2 stomatin and CPEB4 biomolecular condensates, and quantify the complex viscoelastic properties of intracellular compartments of zebrafish progenitor cells. In Caenorhabditis elegans, we uncover how mutations in the nuclear envelope proteins LMN-1 lamin A, EMR-1 emerin and LEM-2 LEMD2, which cause premature aging disorders in humans, soften the cytosol of intestinal cells during organismal age. We demonstrate that time-shared optical tweezer microrheology offers the rapid phenotyping of material properties inside cells and protein blends, which can be used for biomedical and drug-screening applications.

01 Feb 2025·Gastroenterology

Overlap of Genomic and Transcriptomic Genes Identified in Familial Eosinophilic Esophagitis

Article

Author: Clayton, Frederic ; Allen-Brady, Kristina ; Cessna, Melissa ; Pyne, Ashley L ; Peterson, Kathryn A ; Hazel, Mark W ; Fang, John ; Stubben, Chris ; Pletneva, Maria A ; Stevens, Jeff ; Robson, Jacob

BACKGROUND & AIMSEvidence for a genetic contribution to eosinophilic esophagitis (EoE) exists from family and genome-wide association studies. Extensive investigation into rare variants contributing to EoE has not been performed. The study's aim was to evaluate families with multiple cases of EoE by genomic and transcriptomic sequencing to identify genes predisposing to EoE.METHODSDistant relative pairs (eg, cousins) in extended EoE families and other affected relatives were whole exome sequenced to identify rare, shared, potentially pathologic variants. RNA sequencing was performed in nuclear families with multiple EoE cases. We compared the overlap of genes from DNA and RNA sequencing for relevance to disease manifestations.RESULTSWhole exome sequencing was performed in 50 familial cases in 21 EoE extended pedigrees. We observed 189 rare candidate predisposition variants in 181 genes with complete sharing among all affected family members within each pedigree. RNA sequencing was performed for 43 EoE cases in 18 nuclear families, including 6 relatives without EoE. We observed 698 total differentially expressed genes compared with controls. We identified 3 genes (MUC16, ADGRE1, and TENM3) with evidence of rare variant sharing among all affected family members and differential gene expression. We identified 36 other genes with partial sharing of rare variants among some affected family members and with differential gene expression. Several genes identified as prominent in EoE were also differentially expressed in unaffected relatives.CONCLUSIONSGenes related to immune response, barrier dysfunction, and cell adhesion were identified in familial EoE cases and unaffected family members, supporting a genetic familial predisposition and a possible multihit background to disease pathophysiology.

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EMR1

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