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Last update 08 May 2025

IGFBP7

Last update 08 May 2025

Basic Info

Synonyms

FSTL2, IBP-7, IGF-binding protein 7

+ [12]

Introduction

Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180).

Drugs associated with IGFBP7

CN115212302

Patent Mining

Target

IGFBP7

Mechanism-

Active Org.

People's Liberation Army Air Force Military Medical University

Originator Org.

People's Liberation Army Air Force Military Medical University

Active Indication

Immune System Diseases [+3]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with IGFBP7

100 Translational Medicine associated with IGFBP7

0 Patents (Medical) associated with IGFBP7

1,094

Literatures (Medical) associated with IGFBP7

31 Dec 2025·Annals of Medicine

Association between serum levels of insulin-like growth factor-binding proteins at admission and outcomes at 3 months after acute ischemic stroke

Article

Author: Wang, Huan ; Zhang, Shihong ; Hao, Zilong ; Zhu, Yuyi ; Cui, Ting ; Chen, Yaqi ; Wu, Simiao ; Chen, Mingxi ; Leng, Xinyi ; Wang, Deren

BACKGROUNDInsulin-like growth factor-binding proteins (IGFBPs) contribute to central nervous system development and may influence recovery after stroke. This study aimed to determine whether serum IGFBPs levels in acute ischemic stroke (AIS) patients are associated with 3-month outcomes.MATERIALS AND METHODSWe retrospectively reviewed data from AIS patients admitted within 24 h after stroke onset, and who had been prospectively enrolled in the Chengdu Stroke Registry. Serum IGFBPs 4, 6 and 7 levels at admission were compared between patients experienced good outcome (modified Rankin Scale scores of 0-2) or poor outcome (scores of 3-6) at 3 months after stroke onset. Factors associated with good outcome were identified using logistic regression.RESULTSAmong 194 patients, 115 (59.3%) experienced good outcome at 3 months. Patients with good outcome showed significantly higher levels of all three IGFBPs at admission. Good outcome was independently associated with higher serum levels of IGFBP 4 (OR 1.013, 95% CI 1.005-1.020) and IGFBP 7 (OR 1.012, 95% CI 1.003-1.021) after adjustment for potential confounders. Adding either or both IGFBPs to a model based on conventional clinical factors significantly improved good outcome prediction, with net reclassification improvement of 41.9-54.5% and integrated discrimination improvement of 3.8-5.8%. The model containing both IGFBPs predicted good outcome with an area of 0.878 (95% CI 0.827-0.929) under the receiver operating characteristic curve.CONCLUSIONSHigher serum IGFBPs 4 and 7 levels may be associated with greater probability of good outcome at 3 months after AIS.

01 Apr 2025·JGH Open

Urine TIMP2.IGFBP7 Reflects Kidney Injury After Moderate Volume Paracentesis in Patients With Ascites: A Randomized Control Study

Article

Author: Khaoprasert, Sanpolpai ; Chirapongsathorn, Sakkarin ; Suksamai, Anuchit ; Chaiprasert, Amnart

ABSTRACTBackgroundUrinary biomarkers may predict acute kidney injury (AKI) in cirrhosis with ascites in a moderate volume paracentesis setting.ObjectiveThe study aimed to assess the risk and consequence of AKI and its progression in patients with decompensated cirrhosis undergoing paracentesis using a urine test measuring tissue inhibitor of metalloproteinases‐2 (TIMP2) and insulin‐like growth factor‐binding protein 7 (IGFBP7).MethodsA randomized, controlled trial was performed. All outpatients with decompensated cirrhosis with ascites and diuretic complications were enrolled and randomized into 3 and 5 L paracentesis groups. Serial urine samples were analyzed for TIMP2. IGFBP7 concentration before and after paracentesis.ResultsA total of 90 patients with decompensated cirrhosis were consecutively enrolled during the study period. After screening, 29 patients were enrolled in the 3‐L paracentesis group, and 25 patients were enrolled in the 5‐L paracentesis group. The mean of the MELD score was 8 ± 1.2. Urine TIMP2.IGFBP7 > 2, rising urine TIMP2, and rising urine TIMP2/urine Cr were shown in patients within the 5‐L group for 48% (p = 0.015), 32% (p = 0.049), and 76% (p = 0.010) respectively, indicating a higher incidence of renal tubular injury markers in this group. Urine TIMP2.IGFBP7/1000 > 2 was statistically significant to predict a hemodynamic event (p = 0.002).ConclusionIn cirrhotic patients with ascites undergoing paracentesis, a 5‐L paracentesis volume was associated with a higher incidence of renal tubular injury markers.Trail Registration: The national clinical registration number was TCTR20191116003.

01 Apr 2025·Journal of Dairy Science

Genomic selection and weighted single-step genome-wide association study of sheep body weight and milk yield: Imputing low-coverage sequencing data with similar genetic background panels

Article

Author: An, X ; Xiao, Y ; Xu, X ; Chen, Z ; Song, Y ; Zhang, L ; Jiang, Y ; Li, D ; Li, R ; Chen, X ; Zhao, X

Low-coverage whole-genome sequencing (LcWGS), a cost-effective genotyping method, offers greater flexibility in variant detection than SNP chips. However, to our knowledge, no studies have explored the application of LcWGS in sheep. This study aimed to evaluate the feasibility of implementing LcWGS and genotype imputation and assess their applicability in genomic studies of body weight and milk yield in sheep. A total of 45,787 birth weight (BiW), 31,135 weaning daily gain (WDG), 8,928 milk yield (MY), and 4,918 milk yield per unit of metabolic body weight (MWMY) data records were analyzed. Among these, 2,366 sheep had imputed high-density genotypes. Simulated sequencing depths from 0.1× to 3× were imputed using reference panels of 100 to 600 individuals. Genotype concordance with true data improved from 0.8875 to 0.9852 as the sequencing depth and panel size increased. The single-step GBLUP method applied to the imputed data yielded higher accuracy for BiW, WDG, MY, and MWMY than the classical pedigree-based BLUP, and notably increased MY accuracy from 0.61 to 0.66. Furthermore, a weighted single-step genome-wide association study identified key genes associated with BiW (ANKS1B, OPRM1, CSMD1), WDG (TKDP5, GRP, RAX, IGFBP7), MY (CCSER1, FGGY, HOOK1), and MWMY (NDUFA10, ZNF385D, NWD1), revealing the importance of multiple pathways in sheep growth and milk production. This is the first study to assess the feasibility of combining LcWGS with genotype imputation for sheep genomic selection, balancing economic costs and imputation efficiency. Furthermore, we demonstrate an effective approach for identifying genetic variants linked to body weight and milk production, offering a cost-effective strategy for dairy sheep breeding.

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IGFBP7

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