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Last update 08 May 2025

PSAC

Last update 08 May 2025

Basic Info

Synonyms-

Introduction-

Drugs associated with PSAC

12F

Target

PSAC

Mechanism

PSAC inhibitors

Active Org.-

Originator Org.

CSIR-Indian Institute of Chemical Biology

Active Indication-

Inactive Indication

Plasmodium knowlesi infection

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

PSAC Inhibitor (Microbiotix)

Target

PSAC

Mechanism

PSAC inhibitors

Active Org.-

Originator Org.

Microbiotix, Inc.

Active Indication-

Inactive Indication

Malaria

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Antiplasmodial and antileishmanial(The University of North Carolina)

Target

PSAC

Mechanism

PSAC inhibitors

Active Org.-

Originator Org.

The University of North Carolina at Chapel Hill

Active Indication-

Inactive Indication

Leishmaniasis [+1]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PSAC

100 Translational Medicine associated with PSAC

0 Patents (Medical) associated with PSAC

292

Literatures (Medical) associated with PSAC

01 Apr 2025·BMJ Paediatrics Open

Predictors of persisting symptoms after concussion in children following a traumatic brain injury: a longitudinal retrospective cohort study

Article

Author: Pocock, Lucy ; Wright, Ingram ; Lyttle, Mark D ; Wilson, Rebecca ; Jackson, Joni ; Williams, Cathy ; Scott, Lauren J ; Burrell, Alex ; Birnie, Kate ; Hong, Jialan ; Ijaz, Sharea ; Redaniel, Maria Theresa ; Savovic, Jelena ; Booker, Matthew ; Mytton, Julie ; Haythornthwaite, Giles

ObjectivesTo identify predictors of persisting symptoms after concussion (PSaC) in children, following any medically attended traumatic brain injury (TBI).DesignRetrospective cohort study.SettingLinked primary and secondary care data from UK Clinical Practice Research Datalink and Hospital Episode Statistics.ParticipantsChildren aged 1–17 years with a medically attended TBI between 2013 and 2017.Main outcome measureA binary indicator of PSaC or suspected PSaC, measured using either a clinical code for PSaC or medical attendances for one or more PSaC symptoms 3–12 months after TBI.ResultsWe identified 137 873 children with a TBI; 4620 (3.4%) had PSaC or suspected PSaC. More females (3.8%) had PSaC than males (3.1%). Those with PSaC were older at the time of TBI compared with those without PSaC (8 vs 5.5 years). In a multivariable logistic regression model, older age (OR =1.02 per year increase in age, 95% CI 1.01 to 1.03), female sex (OR=1.20, 95% CI 1.13 to 1.28), being Asian (OR=1.37, 95% CI 1.22 to 1.54) or mixed ethnicity (OR=1.18, 95% CI 1.01 to 1.37) (compared with white ethnicity), having a history of headaches (OR=3.52, 95% CI 3.13 to 3.95), learning disabilities (OR=2.06, 95% CI 1.69 to 2.52), ADHD (OR=2.41, 95% CI 1.91 to 3.04), anxiety (OR=2.58, 95% CI 2.18 to 3.05), depression (OR=4.00, 95% CI 3.28 to 4.89) or sleep disorders (OR=2.35, 95% CI 1.99 to 2.78) were associated with increased odds of PSaC.ConclusionsThese results may be used to identify children more likely to develop PSaC following a TBI and those who may benefit from targeted healthcare for PSaC symptoms. Identifying cases of PSaC in primary care data was challenging as perhaps many children do not attend services for suspected PSaC or, if they did, are not diagnosed with PSaC. Furthermore, the clinical predictors are a measure of healthcare access for these symptoms; thus, results could be influenced by patient or carer’s health-seeking behaviour.

01 Feb 2025·Brain and Behavior

Differential Abnormality in Regional Brain Spontaneous Activity and Functional Connectivity in Patients of Non‐Acute Subcortical Stroke With Versus Without Global Cognitive Functional Impairment

Article

Author: Rao, Jiang ; Wang, Yao ; Yu, Hao ; Yang, Wenjie ; Ma, Hongxia ; Liu, Wan ; Chai, Xue ; Liu, Li ; Xu, Guangxu ; Hu, Zhibin

ABSTRACTIntroductionCognitive impairment after a stroke significantly affects patients' quality of life, yet not all strokes lead to such impairment, and the underlying reasons remain unclear. This study employs resting‐state functional magnetic resonance imaging (rs‐fMRI) to compare subcortical stroke patients with and without cognitive impairment. Our goal is to identify distinct abnormalities in regional brain spontaneous activity and functional connectivity (FC) to better understand the neural basis of post‐stroke cognitive outcomes.MethodsA total of 62 first‐ever non‐acute subcortical stroke patients were classified into post‐stroke with abnormal cognition (PSAC) and with normal cognition (PSNC) groups. Rs‐MRI was utilized to assess regional homogeneity (ReHo) in 32 PSAC, 30 PSNC, and 62 age‐ and sex‐matched healthy controls (HC). Then we performed the seed‐based whole‐brain FC analysis based on the ReHo results. A partial correlation analysis examined the relationship between altered ReHo or FC and Montreal Cognitive Assessment (MoCA) scores.ResultsIt showed varied activity in cognitive‐related brain regions in both stroke groups compared to HC, such as the right superior frontal gyrus, the right middle temporal gyrus, the right postcentral gyrus, and the left cerebellar lobules. The PSAC group had increased activity in the bilateral inferior temporal gyrus as well. Significant differences in activity were also found between PSAC and PSNC groups, with the PSAC group showing decreased activity in the left gyrus rectus (REC) and increased activity in cerebellar lobules. FC analysis revealed decreased connections in the PSAC group, particularly involving the left REC. Activity and FC in left REC and cerebellum also significantly correlated with MoCA scores.ConclusionsThese findings suggest unique patterns of brain activity and connectivity in non‐acute subcortical stroke patients with cognitive impairment, shedding light on potential neural mechanisms underlying post‐stroke cognitive impairment. While the left REC may be a potential neural regulatory stimulus target in clinical applications.

01 Feb 2025·Small

A Moldable, Tough Mineral‐Dominated Nanocomposite as a Recyclable Structural Material

Article

Author: Liao, Peng ; Zhou, Lina ; Gong, Junbo ; Ma, Yanyu ; Gong, Zeyu ; Yu, Yadong ; Li, Yexuan

AbstractFlexible hybrid minerals, primarily composed of inorganic ionic crystal nanolines and a small amount of organic molecules, have significant potential for the development of sustainable structural materials. However, the weak interactions and insufficient crosslinking among the inorganic nanolines limit the mechanical enhancement and application of these hybrid minerals in high‐strength structural materials. Inspired by tough biominerals and modern reinforced concrete structures, this study proposes introducing an aramid nanofiber (ANF) network as a flexible framework during the polymerization of calcium phosphate oligomers (CPO), crosslinked by polyvinyl alcohol (PVA) and sodium alginate (SA). This approach allows the flexible inorganic nanolines formed through CPO polymerization to be integrated into the organic framework, thereby creating tough mineral‐based structural materials (inorganic content: 70.7 wt.%), denoted as PVA/SA/ANF/CPO (PSAC). The multiple intermolecular interactions between the organic and inorganic phases, combined with the integrated nano‐reinforced concrete structure, endow PSAC with significantly enhanced tensile strength (86.6 ± 8.6 MPa), comparable to that of high‐strength polymer plastics. Moreover, PSAC possesses excellent plasticity and flame retardancy. The noncovalent molecular interactions within PSAC enable efficient recyclability. Consequently, PSAC has the potential to replace high‐strength polymer plastics and structural components, providing a promising avenue for developing high‐strength and toughness mineral‐based structural materials.

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PSAC

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