Last update 01 Nov 2024

SERT x nNOS

Last update 01 Nov 2024

Basic Info

Related Targets

SERTnNOS

Drugs associated with SERT x nNOS

ZZL-7

Target

SERT x nNOS

Mechanism

SERT inhibitors [+1]

Active Org.

Xuzhou Medical University [+1]

Originator Org.

Nanjing Medical University

Active Indication

Depressive Disorder, Major

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with SERT x nNOS

100 Translational Medicine associated with SERT x nNOS

0 Patents (Medical) associated with SERT x nNOS

Literatures (Medical) associated with SERT x nNOS

01 Sep 2023·Neuroscience bulletin

nNOS and Neurological, Neuropsychiatric Disorders: A 20-Year Story.

Review

Author: Li, Fei ; Zhu, Dong-Ya ; Zhu, Li-Juan

In the central nervous system, nitric oxide (NO), a free gas with multitudinous bioactivities, is mainly produced from the oxidation of L-arginine by neuronal nitric oxide synthase (nNOS). In the past 20 years, the studies in our group and other laboratories have suggested a significant involvement of nNOS in a variety of neurological and neuropsychiatric disorders. In particular, the interactions between the PDZ domain of nNOS and its adaptor proteins, including post-synaptic density 95, the carboxy-terminal PDZ ligand of nNOS, and the serotonin transporter, significantly influence the subcellular localization and functions of nNOS in the brain. The nNOS-mediated protein-protein interactions provide new attractive targets and guide the discovery of therapeutic drugs for neurological and neuropsychiatric disorders. Here, we summarize the work on the roles of nNOS and its association with multiple adaptor proteins on neurological and neuropsychiatric disorders.

01 Aug 2023·Neuroscience bulletin

Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants.

Article

Author: Ye, Qing ; Tang, Yong ; Lin, Si-Si ; Ulrich, Henning

01 Jun 2023·Molecular Ecology

Investigating the genetic basis of vertebrate dispersal combining RNA‐seq, RAD‐seq and quantitative genetics

Article

Author: Clobert, Jean ; Yurchenko, Andrey A ; Winandy, Laurane ; Elmer, Kathryn R ; Guillaume, Olivier ; San-Jose, Luis M ; Recknagel, Hans ; Bonneaud, Camille ; Richard, Murielle ; Cote, Julien ; Salmona, Jordi ; Legrand, Delphine ; Calvez, Olivier ; Pellerin, Félix ; Bestion, Elvire ; Di Gesu, Lucie

AbstractAlthough animal dispersal is known to play key roles in ecological and evolutionary processes such as colonization, population extinction and local adaptation, little is known about its genetic basis, particularly in vertebrates. Untapping the genetic basis of dispersal should deepen our understanding of how dispersal behaviour evolves, the molecular mechanisms that regulate it and link it to other phenotypic aspects in order to form the so‐called dispersal syndromes. Here, we comprehensively combined quantitative genetics, genome‐wide sequencing and transcriptome sequencing to investigate the genetic basis of natal dispersal in a known ecological and evolutionary model of vertebrate dispersal: the common lizard, Zootoca vivipara. Our study supports the heritability of dispersal in semi‐natural populations, with less variation attributable to maternal and natal environment effects. In addition, we found an association between natal dispersal and both variation in the carbonic anhydrase (CA10) gene, and in the expression of several genes (TGFB2, SLC6A4, NOS1) involved in central nervous system functioning. These findings suggest that neurotransmitters (serotonin and nitric oxide) are involved in the regulation of dispersal and shaping dispersal syndromes. Several genes from the circadian clock (CRY2, KCTD21) were also differentially expressed between disperser and resident lizards, supporting that the circadian rhythm, known to be involved in long‐distance migration in other taxa, might affect dispersal as well. Since neuronal and circadian pathways are relatively well conserved across vertebrates, our results are likely to be generalisable, and we therefore encourage future studies to further investigate the role of these pathways in shaping dispersal in vertebrates.

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