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Topline GSBR-1290 Phase 2a 12-week obesity data, as well as data from formulation bridging and titration optimization study, on track for latter half of the second quarter 2024 Phase 2b study in obesity expected to begin as planned in the fourth quarter 2024 Year-end cash balance of $467.3 million expected to fund operations and key clinical milestones through 2026 SAN FRANCISCO, March 08, 2024 (GLOBE NEWSWIRE) -- Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical-stage global biopharmaceutical company developing novel oral small molecule therapeutics for metabolic and cardiopulmonary diseases, today reported financial results for the fourth quarter and full year ended December 31, 2023, and highlighted recent corporate achievements. “In 2023 we demonstrated clear proof-of-concept with our lead GLP-1 receptor agonist, GSBR-1290, for obesity and type 2 diabetes. As a differentiated oral small molecule we have the scalability and manufacturing advantages to potentially meet the significant unmet need currently observed in the GLP-1 space,” said Raymond Stevens, Ph.D., Founder and CEO of Structure Therapeutics. “With a year-end cash balance of $467.3 million providing runway through the end of 2026, we are well-positioned to initiate and complete our Phase 2b trials for GSBR-1290 and accelerate development of our oral small molecule programs targeting amylin, GIP, and apelin receptors.” Recent Highlights and Upcoming Milestones GSBR-1290 for Type 2 Diabetes Mellitus (T2DM) and Obesity In December 2023, the Company reported clinically meaningful data from the Phase 2a study in T2DM demonstrating significant reductions in hemoglobin A1c (HbA1c) and weight at 12 weeks. Interim Phase 2a data from the obesity cohort demonstrated significant reduction in weight at 8 weeks. Across both cohorts, GSBR-1290 was generally well-tolerated with no treatment-related serious adverse events over 12 weeks and low study discontinuation rates due to adverse events related to study drug (2.8% in T2DM and 0% in obesity).Topline data from the obesity cohort of the Phase 2a study, including full 12-week efficacy data for 40 participants and safety and tolerability for all 64 participants. This study is fully enrolled and data are expected in the latter half of the second quarter of 2024.In preparation for later stage clinical trials, a formulation bridging and titration optimization study to evaluate capsule versus tablet pharmacokinetics (PK) and explore different titration regimens of GSBR-1290 is ongoing. This study is fully enrolled and data are expected in the latter half of the second quarter of 2024.The Company plans to initiate a global Phase 2b obesity study of GSBR-1290 in the fourth quarter of 2024.The Company plans to initiate a Phase 2 study in T2DM in the second half of 2024. GLP-1R Combination Programs: Amylin, GIPR, Apelin (APJR) Oral Small Molecule Amylin Program: The Company is developing amylin agonists for use either alone or in combination with GLP-1R agonists to treat obesity and associated diseases, and expects to select a development candidate in the second half of 2024.Oral Small Molecule GIPR Program: The Company is developing a GIPR selective agonist and GLP‑1R/GIPR combinations to treat obesity and associated diseases, and expects to select a development candidate in the first half of 2025.Oral Small Molecule Apelin Receptor (APJR) Program: The Company is evaluating its Phase 2 ready ANPA-0073, a biased agonist targeting APJR used in combination with weight loss medicines, for selective or muscle-sparing weight loss. ANPA-0073 is also being evaluated for idiopathic pulmonary fibrosis (IPF). The Company has completed a Phase 1 single-ascending and multiple-ascending dose study, in which ANPA-0073 was generally well-tolerated with no serious adverse event reported. LPA1R Program for Idiopathic Pulmonary Fibrosis (IPF) The Company is developing LTSE-2578, an oral small molecule antagonist that targets lysophosphatidic acid 1 receptor (LPA1R). Preclinical studies have demonstrated substantial anti-fibrotic activity in mouse models of fibrotic lung disease, and the Company expects to initiate a first-in-human study of LTSE-2578 in the second quarter of 2024. Corporate In 2023, the Company raised approximately $485.0 million of equity capital: $185.0 million in gross proceeds from the initial public offering in February, and $300.0 million in gross proceeds from the private placement equity financing in October. Fourth Quarter and Full Year 2023 Financial Highlights Cash Position: Cash, cash equivalents and short-term investments totaled $467.3 million at December 31, 2023. The Company expects its current cash, cash equivalents and short-term investments to fund operations and expected key clinical milestones through at least 2026. R&D Expenses: Research and development (R&D) expenses for the fourth quarter of 2023 were $20.0 million, as compared to $8.4 million for the same period in 2022. For the year ended December 31, 2023, R&D expenses were $70.1 million, as compared to $36.2 million for the full year 2022. The increase was primarily due to the advancement of the Company’s GLP-1R franchise and other research programs, clinical study activities and increases related to employee expenses, primarily due to an increase in personnel. G&A Expenses: General and administrative (G&A) expenses for the fourth quarter of 2023 were $11.0 million, as compared to $4.6 million for the same period in 2022. For the year ended December 31, 2023, G&A expenses were $32.7 million, as compared to $16.4 million for the full year 2022. The increase was primarily due to increases in professional services and employee related expenses as the Company expanded its infrastructure to drive and support the growth in its operations as a publicly-traded company. Net Loss: Net loss for the fourth quarter of 2023 totaled $24.5, with non-cash stock-based compensation expense of $2.1 million, compared to $11.9 million for the fourth quarter of 2022 with non-cash stock-based compensation expense of $0.6 million. For the year ended December 31, 2023, net loss totaled $89.6 million, with non-cash stock-based compensation expense of $8.2 million, compared to $51.3 million for the full year 2022 with non-cash stock-based compensation expense of $2.5 million. About Structure TherapeuticsStructure Therapeutics is a leading clinical-stage biopharmaceutical company focused on discovering and developing innovative oral treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Utilizing its next generation structure-based drug discovery platform, the Company has established a scientifically-driven, GPCR-targeted pipeline, featuring two wholly-owned proprietary clinical-stage small molecule compounds designed to surpass the limitations of traditional biologic and peptide therapies and be accessible to more patients around the world. For additional information, please visit www.structuretx.com. Forward Looking Statements This press release contains “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are statements that could be deemed forward-looking statements, including, without limitation, statements concerning the Company’s future plans and prospects, the Company’s anticipated cash runway, the clinical update from Structure’s Phase 2a study of GSBR-1290 in patients with T2DM and obesity, any expectations regarding the safety, efficacy or tolerability of GSBR-1290 and other candidates under development, the ability of GSBR-1290 to treat T2DM, obesity or related indications, the planned initiation and study design of Structure’s Phase 2b studies for GSBR-1290 in patients with T2DM and obesity and the timing thereof, and first-in-human study of LTSE-2578 and the timing thereof, respectively, the selection of a development candidate for the Company’s amylin receptor agonist program and GLP-1R/GIPR program, the planned timing of the Company’s data results and continued development of GSBR-1290, amylin and next generation GLP-1R/GIPR combination candidates and expectations regarding an oral development candidate targeting GLP-1R. In addition, when or if used in this press release, the words “may,” “could,” “should,” “anticipate,” “believe,” “estimate,” “expect,” “intend,” “plan,” “predict” and similar expressions and their variants, as they relate to the Company may identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Although the Company believes the expectations reflected in such forward-looking statements are reasonable, the Company can give no assurance that such expectations will prove to be correct. Readers are cautioned that actual results, levels of activity, safety, performance or events and circumstances could differ materially from those expressed or implied in the Company’s forward-looking statements due to a variety of risks and uncertainties, which include, without limitation, risks and uncertainties related to the preliminary nature of the results due to length of the study and sample size, the risks that unblinded data is not consistent with blinded data, the Company’s ability to advance GSBR-1290, LTSE-2578, ANPA-0073 and its other therapeutic candidates, obtain regulatory approval of and ultimately commercialize the Company’s therapeutic candidates, the timing and results of preclinical and clinical trials, the impact of any data collection omissions at any of our clinical sites, the Company’s ability to fund development activities and achieve development goals, the impact of any global pandemics, inflation, supply chain issues, rising interest rates and future bank failures on the Company’s business, its ability to protect its intellectual property and other risks and uncertainties described in the Company’s filings with the Securities and Exchange Commission (SEC), including the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2023, as filed with the SEC on November 17, 2023, and future reports the Company may file with the SEC from time to time. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management’s assumptions and estimates as of such date. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law. STRUCTURE THERAPEUTICS INC.Condensed Consolidated Statements of Operations(unaudited)(In thousands, except per share amounts) THREE MONTHS ENDED YEAR ENDED DECEMBER 31, DECEMBER 31, 2023 2022 2023 2022Operating expenses: Research and development $20,042 $8,360 $70,103 $36,193 General and administrative 10,952 4,596 32,672 16,368 Total operating expenses 30,994 12,956 102,775 52,561 Loss from operations (30,994) (12,956) (102,775) (52,561)Interest and other income (expense), net 6,179 901 13,391 1,257 Loss before provision for income taxes (24,815) (12,055) (89,384) (51,304)Provision for income taxes (312) (180) 236 17 Net loss $(24,503) $(11,875) $(89,620) $(51,321) STRUCTURE THERAPEUTICS INC.Condensed Consolidated Balance Sheet Data(unaudited)(In thousands) DECEMBER 31, 2023 2022Assets Current assets: Cash, cash equivalents and short-term investments $467,323 $90,841 Prepaid expenses and other current assets 6,285 2,248 Total current assets 473,608 93,089 Property and equipment, net 3,228 1,031 Operating right-of-use assets 5,136 262 Other non-current assets 45 3,463 Total assets $482,017 $97,845 Liabilities, redeemable convertible preferred shares and shareholders’ equity (deficit) Current liabilities: Accounts payable $4,742 $6,009 Accrued expenses and other current liabilities 18,558 6,741 Operating lease liabilities, current portion 1,440 260 Total current liabilities 24,740 13,010 Operating lease liabilities, net of current portion 4,013 — Other non-current liabilities 298 — Total liabilities 29,051 13,010 Redeemable convertible preferred shares issuable in series — 199,975 Total shareholders’ equity (deficit) 452,966 (115,140)Total liabilities, redeemable convertible preferred shares and shareholders’ equity (deficit) $482,017 $97,845 Investors:Danielle KeatleyStructure Therapeutics Inc.ir@structuretx.com Media:Dan Budwick1ABDan@1abmedia.com

$6M early-stage biotech investment supplemented by $2.3M non-dilutive grant funding ENCINITAS, Calif., Jan. 3, 2024 /PRNewswire/ -- Vasa Therapeutics, Inc. ("Vasa"), a preclinical stage biopharmaceutical company developing novel therapies for cardiovascular aging, announced today the closing of series seed funding led by Orphinic Scientific SA ("Orphinic"), an early-stage investor focused on companies with game-changing potential. The round also included participation from private investments funds NuFund Venture Group, SeedFolio, and others. "We are delighted to gain support from a high-quality group of US and international investors who share Vasa's mission to develop transformative therapies for cardiovascular aging that could extend the healthy lifespan," said Artur Plonowski, MD, PhD, CEO and Co-founder of Vasa. "This closing comes at an exciting time for Vasa as VS-041, our clinical candidate for heart failure with preserved ejection fraction (HFpEF), enters the final stages of preclinical development with favorable FDA feedback at a recent pre-IND meeting." "We are excited to have led the seed financing for Vasa. The company's novel biomarker strategy can lead to a personalized medicine-based therapy for HFpEF, a highly heterogenous disease, for which the currently available drugs do not provide durable improvement," said Adam Kruszewski, CEO of Orphinic. "We are also pleased to see multiple opportunities for the other Vasa assets, including sarcopenia, obesity, and peripheral artery disease." Orphinic's chairman of supervisory board, Prof. Jarosław Leszczyszyn, will join Vasa's board of directors and represent this round of seed investors. Pillsbury Winthrop Shaw Pittman LLP served as legal counsel to Vasa. About Vasa Therapeutics Vasa is a privately held biopharmaceutical company developing therapeutics that target pathophysiology of cardiovascular aging: VS-041 is the first potential personalized medicine-based treatment of HFpEF. VS-041 shows robust reduction of cardiac fibrosis in preclinical HFpEF model and inhibits release of signaling collagen fragments, such as PRO-C6, that mediate fibroinflammatory responses and are biomarkers of worse outcomes in HFpEF patients. Phase 1 clinical trial of VS-041 is planned for Q2 2024. Long acting apelin peptide analogs for combination treatment with incretins in obesity patients at risk for skeletal muscle loss or cardiovascular disease. As a monotherapy, long acting apelin agonists could also be beneficial in muscle atrophy, heart failure, chronic kidney disease, and peripheral artery disease. A best-in-class inhibitor of CamKIId for heart failure and life-threatening arrhythmias. For more information, please visit Media contact: [email protected] SOURCE Vasa Therapeutics

Company leadership and scientists will appear at LSX World Congress (May 3), Keystone conference on neurodegeneration (May 15–19), Age-related Disease Therapeutics Summit (June 1-2), and BIO International (June 7) RICHMOND, Calif.--(BUSINESS WIRE)-- BioAge Labs, Inc. (“BioAge”), a privately held clinical-stage biotechnology company developing therapeutics that target the molecular causes of aging to extend healthy human lifespan, today announced that the company will provide updates on the company's progress in novel target identification and drug development in the brain aging area at upcoming conferences in the US and UK. “Brain aging can lead to devastating neurological conditions, which affect millions of people every year,” said Kristen Fortney, PhD, CEO and co-founder of BioAge. “Our discovery platform reveals biological drivers of cognitive decline that could be targeted with novel therapeutics to prevent, slow, or reverse neurodegeneration across the full continuum of disease, from early stages to established dementias. We are excited to share our innovative clinical vision and strategies with partners and investors at leading conferences this quarter.” The BioAge platform has implicated multiple mechanisms in brain aging, including chronic activation of the NLRP3 inflammasome and declining apelin pathway activity. BioAge is developing a novel class of CNS-penetrant NLRP3 inhibitors for neurodegenerative and neurosensory disorders associated with aging, and its apelin receptor agonist BGE-105 for multiple indications. BioAge will present on these programs at the following events: 9th Annual LSX World Congress; London, UK; May 3 [link] — BioAge CBO and Head of Brain Aging Peng Leong PhD, MBA will participate in a panel discussion, entitled “Immuno-inflammation: A doorway to new partners and therapeutic areas.” Leong will be joined on the panel by Toby Richardson, Senior Director, Early Innovation Partnering Immunology, EMEA at Johnson & Johnson Innovation; Rachel Strick, Head of Immunology BD & Acquisitions, AbbVie; and Vishal Sahni, Director, Corporate Business Development & Strategy at Lundbeck. Keystone Symposium on “Neurodegeneration: New Biology Guiding the Next Generation of Therapeutic Development”; Whistler, BC; May 15–19 [link] — BioAge researcher Adam Lundquist, PhD will deliver a poster titled “Apelin receptor agonist BGE-105 ameliorates multiple mechanisms that drive neuroinflammation and neurodegeneration.” 5th Age-related Disease Therapeutics Summit, San Francisco, June 2 [link]: Leong will join a panel entitled “Strengthening the Synergy Between Pharma & Biotech”. Leong will be joined on the panel by Shamina Rangwala, Executive Director, Emerging Science, Innovation & Global Internal Medicine Lead, Pfizer; and Alexander Pickett, Managing Director, Juvenescence. Topics to be addressed include the diseases on which biotech and pharma should focus to improve healthy longevity, including neurodegenerative diseases driven by brain aging. BIO International Convention; Boston, MA, June 7 [link] — BioAge CEO and co-founder Kristen Fortney, PhD will lead a panel discussion entitled “Treating neurodegeneration by targeting the mechanisms of aging”. Panelists will be Fiona Elwood, VP, Disease Area Stronghold Lead, Neurodegeneration, Janssen; Howard Fillit, Chief Science Officer, Alzheimer's Drug Discovery Foundation; Sam Jackson, Chief Medical Officer, Neuron23; and Dirk Landgraf, VP, Dementia Discovery Fund, SV Health Investors. “BioAge is deeply rooted in human biology and data, enabling us to uncover diverse strategies for promoting healthy aging and preventing age-related diseases,” said Leong. “Our mission of understanding the mechanisms of brain aging enables us to pursue the development of therapies with far-reaching potential and impact.” About BioAge Labs, Inc. BioAge is a clinical-stage biotechnology company developing a pipeline of treatments to extend healthy lifespan by targeting the molecular causes of aging. The company uses its discovery platform, which combines quantitative analysis of proprietary longitudinal human samples with detailed health records to map out the key molecular pathways that impact healthy human aging. By targeting the mechanisms of aging with a large and mechanistically diverse portfolio of drugs, BioAge is unlocking opportunities to treat or even prevent age-related disease in entirely new ways. BioAge's growing portfolio includes multiple assets targeting muscle, immune, and brain aging. To date, BioAge has raised $127M from Andreessen Horowitz, Kaiser Foundation Hospitals, and others.