Last update 01 Nov 2024

PKP3

Last update 01 Nov 2024

Basic Info

Synonyms

PKP3, plakophilin 3, Plakophilin-3

Introduction

May play a role in junctional plaques.

Drugs associated with PKP3

CN116920102

Patent Mining

Target

PKP3

Mechanism-

Active Org.

South China University of Technology

Originator Org.

South China University of Technology

Active Indication

Inflammation [+1]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

HG-1212

Target

PKP3

Mechanism

PKP3 gene modulators

Active Org.-

Originator Org.

Human Genome Sciences, Inc.

Active Indication-

Inactive Indication

Neoplasms

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PKP3

100 Translational Medicine associated with PKP3

0 Patents (Medical) associated with PKP3

100

Literatures (Medical) associated with PKP3

01 Nov 2024·International Journal of Biological Macromolecules

Chemical structures and immunomodulatory activities of polysaccharides from Polygonatum kingianum

Article

Author: Cheng, Yongxian ; Tian, Yuncai ; Wu, Mingyi ; Ding, Yunzhang ; Li, Xuan ; Chen, Nanyu ; Li, Jiang ; Tian, Yong

The physicochemical properties of the polysaccharides in Polygonatum kingianum, a Chinese medicinal herb used for both medicine and food, have not been fully studied. This study isolated three polysaccharides (PKP-1, PKP-2, and PKP-3) from the dry rhizomes of P. kingianum, with an average molecular weight of approximately 3137 Da, 5341 Da and 3755 Da, respectively. Structural analysis showed that all the three polysaccharides are fructans with β-D-Fruf-(2→, →6)-β-D-Fruf-(2→, →1)-β-D-Fruf-(2→, →1,6)-β-D-Fruf-(2→ and →6)-α-D-Glcp-(1→ glycosidic bond type. Notably, PKP-2 contains both acetyl groups and trace amounts of mannose residues. Scanning electron microscopy indicated that each polysaccharide possesses unique surface morphology. Thermal analysis showed that the three polysaccharides have good thermal stability. Rheological studies further revealed that all the three polysaccharides are typical shear thinning fluids. In vitro experiments showed that PKP-1 and PKP-2 significantly promote the secretion of NO and cytokines (TNF-α, IL-6) in macrophages by activating the NF-κB signaling pathway, thereby demonstrating potential immunomodulatory activity. These findings lay a theoretical foundation for the potential application of Polygonatum polysaccharides in the food industry.

01 Mar 2024·Molecular Therapy - Nucleic Acids

Lnc-CCNH-8 promotes immune escape by up-regulating PD-L1 in hepatocellular carcinoma

Article

Author: Cheng, Niangmei ; Wang, Yang ; Wang, Yingchao ; Zhou, Yang ; Qi, Xin ; Zhuang, Qiuyu ; Zhao, Bixing ; Huang, Jingyun ; Zhong, Yue ; Liu, Xiaolong ; Wang, Fei ; Zheng, Xiaoyuan

Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis. In recent years, immune checkpoint inhibitors (ICIs) have enabled breakthroughs in the clinical treatment of patients with HCC, but the overall response rate to ICIs in HCC patients is still low, and no validated biomarker is available to guide clinical decision making. Here, we demonstrated that the long non-coding RNA Lnc-CCNH-8 is highly expressed in HCC and correlates with poor prognosis. Functionally, elevated Lnc-CCNH-8 inactivated co-cultured T cells in vitro and compromised antitumor immunity in an immunocompetent mouse model. Mechanistically, up-regulated Lnc-CCNH-8 can sponge microRNA (miR)-217 to regulate the expression of PD-L1. In addition, Lnc-CCNH-8 can also stabilize PD-L1 through miR-3173/PKP3 axis. Furthermore, mice bearing tumors with high Lnc-CCNH-8 expression had significant therapeutic sensitivity to anti-PD-L1 monoclonal antibody treatment. More important, HCC patients with high levels of plasma exosomal Lnc-CCNH-8 had a better therapeutic response to ICIs. Taken together, our results reveal the function of Lnc-CCNH-8 in inducing immune escape from CD8⁺ T-cell-mediated killing by up-regulating PD-L1 in a miR-217/miR-3173-dependent manner, which also reveals a novel mechanism of PD-L1 regulation in HCC, and exosomal Lnc-CCNH-8 can serve as a predictive marker for immunotherapy response in HCC.

01 Jan 2024·Cancer Science

Role and function of plakophilin 3 in cancer progression and skin disease

Review

Author: Liu, Yan ; Chen, Jiahui ; Tian, Jia ; Zhang, Yefei ; Zhou, Yehui

AbstractPlakophilin 3 (PKP3), a component of desmosome, is aberrantly expressed in many kinds of human diseases, especially in cancers. Through direct interaction, PKP3 binds with a series of desmosomal proteins, such as desmoglein, desmocollin, plakoglobin, and desmoplakin, to initiate desmosome aggregation, then promotes its stability. As PKP3 is mostly expressed in the skin, loss of PKP3 promotes the development of several skin diseases, such as paraneoplastic pemphigus, pemphigus vulgaris, and hypertrophic scar. Moreover, accumulated clinical data indicate that PKP3 dysregulates in diverse cancers, including breast, ovarian, colon, and lung cancers. Numerous lines of evidence have shown that PKP3 plays important roles in multiple cellular processes during cancer progression, including metastasis, invasion, tumor formation, autophagy, and proliferation. This review examines the diverse functions of PKP3 in regulating tumor formation and development in various types of cancers and summarizes its detailed mechanisms in the occurrence of skin diseases.

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PKP3

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