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Last update 08 May 2025
GPR4
Last update 08 May 2025
Basic Info
Synonyms G protein-coupled receptor 4, G-protein coupled receptor 4, G-protein coupled receptor 6C.l + [2] |
Introduction Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA12/GNA13/Rho pathways (PubMed:12955148, PubMed:17462861, PubMed:20211729, PubMed:22110680). Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway (PubMed:32058960). In the brain may mediate central respiratory sensitivity to CO(2)H(+) (By similarity). |
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100 Clinical Results associated with GPR4
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100 Translational Medicine associated with GPR4
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01 Apr 2025Molecular Cell
Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangement
Article
Author: Xia, Ming ; Rong, Naikang ; Zhang, Mingyue ; Yang, Fan ; Li, Dongfang ; Zhong, Ya-Ni ; Sun, Jin-Peng ; Zhang, Xinxin ; Yang, Gongming ; Qi, Zhimin ; Yu, Xiao ; Yang, Zhao ; Zhang, Qiyue ; Xiao, Peng ; Ping, Yu-Qi ; Liu, Zili ; Guo, Lulu ; Gao, Mingxin ; Ding, Ning ; Liu, Junyan ; Zhu, Kongkai ; Zhang, Minghui ; Gaole, Alatan
01 Apr 2025Molecular Cell
Proton perception and activation of a proton-sensing GPCR
Article
Author: Zhang, Yan ; Zhang, Huibing ; Xu, Ping ; Zhou, Hui ; Ma, Xiangyu ; Ji, Su-Yu ; Xi, Kun ; Cheng, Shizhuo ; Chai, Renjie ; Mao, Chunyou ; Wang, Wei-Wei ; Han, Feng ; Shen, Qingya ; Shen, Dan-Dan ; Chen, Li-Nan ; Cai, Xiujun ; Zhang, Min ; Yang, Lin ; Fu, Yifan ; Liu, Yongfeng
01 Apr 2025Molecular Cell
Unraveling the proton-sensing mechanisms of G protein-coupled receptors: Insights from cryogenic electron microscopy studies
Article
Author: Xue, Chenyang ; Liu, Zhongmin
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