Last update 01 Nov 2024

SECTM1

Last update 01 Nov 2024

Basic Info

Synonyms

K12, Protein K-12, secreted and transmembrane 1

+ [2]

Introduction

May be involved in thymocyte signaling.

Drugs associated with SECTM1

CN117942389

Patent Mining

Target

SECTM1

Mechanism-

Active Org.

Zhongshan Ophthalmic Center

Originator Org.

Zhongshan Ophthalmic Center

Active Indication

Eye Diseases [+1]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with SECTM1

100 Translational Medicine associated with SECTM1

0 Patents (Medical) associated with SECTM1

Literatures (Medical) associated with SECTM1

01 Oct 2024·Aging Cell

Deficiency of SECTM1 impairs corneal wound healing in aging

Article

Author: Ke, Qiong ; Huang, Ying ; Ouyang, Hong ; Lan, Xihong ; Tan, Jieying ; Wang, Li ; Zhu, Jin ; Ji, Jianping ; Zhang, Wang ; Mo, Kunlun

AbstractThe corneal epithelium is the outermost transparent barrier of the eyeball and undergoes continuous self‐renewal by limbal stem cells (LSCs) during its lifetime; however, the impact of aging on LSCs remains largely unknown. Here, we showed that the healing ability of the cornea in elderly macaques (Macaca fascicularis) was significantly decreased compared to that of younger macaques. This delayed wound closure accompanied a disordered cell arrangement and corneal opacity. A novel cytokine, Secreted and Transmembrane 1 (SECTM1), was found to facilitate corneal healing and was upregulated in young macaques upon wounding. Mechanistically, SECTM1 is essential for LSC migration and proliferation, and may partially function through Cell Division Cycle Associated 7 (CDCA7). Notably, the topical application of SECTM1 to aged wounded corneas dramatically promoted re‐epithelialization and improved corneal transparency in both mice and macaques. Our work suggests that aging may impair the expression of healing response factors and injury repair in non‐human primate corneas, and that SECTM1 application could potentially benefit corneal wound healing in clinical treatment.

01 Mar 2024·iScience

An integrative multi-omics approach to characterize interactions between tuberculosis and diabetes mellitus

Article

Author: Santana, Gabriel C ; Arriaga, María B ; Andrade, Alice M S ; Maggitti-Bezerril, Mateus ; Fukutani, Eduardo R ; Andrade, Bruno B ; Cordeiro-Santos, Marcelo ; Araújo-Pereira, Mariana ; Queiroz, Artur T L ; Vinhaes, Caian L ; Rolla, Valeria C ; Figueiredo, Marina C ; Kristki, Afrânio L ; Barreto-Duarte, Beatriz ; Milne, Ginger L ; Sterling, Timothy R

Tuberculosis-diabetes mellitus (TB-DM) is linked to a distinct inflammatory profile, which can be assessed using multi-omics analyses. Here, a machine learning algorithm was applied to multi-platform data, including cytokines and gene expression in peripheral blood and eicosanoids in urine, in a Brazilian multi-center TB cohort. There were four clinical groups: TB-DM(n = 24), TB only(n = 28), DM(HbA1c ≥ 6.5%) only(n = 11), and a control group of close TB contacts who did not have TB or DM(n = 13). After cross-validation, baseline expression or abundance of MMP-28, LTE-4, 11-dTxB2, PGDM, FBXO6, SECTM1, and LINCO2009 differentiated the four patient groups. A distinct multi-omic-derived, dimensionally reduced, signature was associated with TB, regardless of glycemic status. SECTM1 and FBXO6 mRNA levels were positively correlated with sputum acid-fast bacilli grade in TB-DM. Values of the biomarkers decreased during the course of anti-TB therapy. Our study identified several markers associated with the pathophysiology of TB-DM that could be evaluated in future mechanistic investigations.

01 Nov 2023·iScience

SECTM1 is upregulated in immuno-hot tumors and predicts immunotherapeutic efficacy in multiple cancers

Author: Zhou, Jiaofeng ; Mao, Wenjun ; Xu, Junying ; Yin, Yongmei ; Cai, Yun ; Fu, Ziyi ; Song, Chenghu ; Mei, Jie ; Zhu, Yichao

[This corrects the article DOI: 10.1016/j.isci.2023.106027.].

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SECTM1

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