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Last update 23 Jan 2025

miR-1

Last update 23 Jan 2025

Basic Info

Synonyms

fibronectin type III and SPRY domain containing 1, Fibronectin type III and SPRY domain-containing protein 1, FSD1

+ [5]

Introduction

May be involved in microtubule organization and stabilization.

Drugs associated with miR-1

ML316

Target

miR-1

Mechanism

miR-1 inhibitors

Active Org.

Whitehead Institute for Biomedical Research

Originator Org.

Whitehead Institute for Biomedical Research

Active Indication

Mycoses

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with miR-1

100 Translational Medicine associated with miR-1

0 Patents (Medical) associated with miR-1

1,307

Literatures (Medical) associated with miR-1

01 Mar 2025·Marine Pollution Bulletin

Dynamic responses during early development of the sea urchin Strongylocentrotus intermedius to CO2-driven ocean acidification: A microRNA-mRNA integrated analysis

Article

Author: Cui, Dongyao ; Zhang, Weijie ; Chang, Yaqing ; Zhan, Yaoyao ; Yin, Wenlu ; Mai, Wenhong ; Zhao, Tanjun ; Song, Jian

To explore the dynamic molecular responses to CO₂-driven ocean acidification (OA) during the early developmental stages of sea urchins, gametes of Strongylocentrotus intermedius were fertilized and developed to the four-armed larva stage in either natural seawater (as a control; pH_NBS = 7.99 ± 0.01) or acidified conditions (ΔpH_NBS = -0.3, -0.4, and - 0.5 units) according to the prediction for ocean pH by the end of this century. Specimens from five developmental stages (fertilization, cleavage, blastula, prism, and four-armed larva) were collected and comparative microRNA (miRNA) and mRNA transcriptome analyses were performed. The results showed that 1) a total of 22,224 differentially expressed genes (DEGs) and 51 differentially expressed miRNAs (DEMs) were identified in the OA-treated groups compared with the control group. 2) The numbers of both DEGs and DEMs were the largest at the blastula stage, indicating dramatic changes in gene expression. 3) Five "miR-1/DEG" modules were identified as potential biomarkers reflecting the response of sea urchins to OA during the early developmental period. 4) The PI3K/Akt signaling pathway was a key pathway involved in the response of S. intermedius to OA in its early developmental stages. This study deepens our understanding of the dynamic molecular regulatory mechanisms underlying sea urchin responses to CO₂-driven OA.

01 Jan 2025·Physiological Reports

miRNA‐1 regulation is necessary for mechanical overload‐induced muscle hypertrophy in male mice

Article

Author: von Walden, Ferdinand ; Godwin, Joshua S. ; Roberts, Michael D. ; Vechetti, Ivan J. ; Fei, Shengyi ; Mobley, C. Brooks ; Rule, Blake D.

AbstractMicroRNAs (miRNAs) are small, noncoding RNAs that play a critical role in regulating gene expression post‐transcriptionally. They are involved in various developmental and physiological processes, and their dysregulation is linked to various diseases. Skeletal muscle‐specific miRNAs, including miR‐1, play a crucial role in the development and maintenance of skeletal muscle. It has been demonstrated that the expression of miR‐1 decreases by approximately 50% in response to hypertrophic stimuli, suggesting its potential involvement in muscle hypertrophy. In our study, we hypothesize that reduction of miR‐1 levels is necessary for skeletal muscle growth due to its interaction to essential pro‐growth genes. Promoting a smaller reduction of miR‐1 levels, we observed a blunted hypertrophic response in mice undergoing a murine model of muscle hypertrophy. In addition, our results suggest that miR‐1 inhibits the expression of Itm2a, a membrane‐related protein, as potential miR‐1‐related candidate for skeletal muscle hypertrophy. While the exact mechanism in muscle hypertrophy has not been identified, our results suggest that miR‐1‐regulated membrane proteins are important for skeletal muscle hypertrophy.

01 Jan 2025·Current Problems in Cardiology

Role of MicroRNAs in Regulating Sarcoplasmic Reticulum Calcium Handling and Their Implications for Cardiomyocyte Function and Heart Disease

Review

Author: Parker, Victoria Elizabeth ; Carter, Benjamin Alexander

The regulation of calcium signaling within cardiomyocytes is pivotal for maintaining cardiac function, with disruptions in sarcoplasmic reticulum (SR) calcium handling linked to various heart diseases. This review explores the emerging role of microRNAs (miRNAs) in modulating SR calcium dynamics, highlighting their influence on cardiomyocyte maturation, function, and disease progression. We present a comprehensive overview of the mechanisms by which specific miRNAs, such as miR-1, miR-24, and miR-22, regulate key components of calcium handling, including ryanodine receptors, SERCA, and NCX. Notably, we identify critical research gaps, particularly the inconsistent findings regarding miRNA expression in heart disease and the need for standardized experimental conditions. Furthermore, we emphasize the potential of miRNAs as therapeutic targets, given their ability to influence calcium handling pathways and cardiac remodeling. The review also discusses the challenges in translating miRNA research into clinical applications, including the need for safe and effective delivery methods. By synthesizing current knowledge and identifying areas for future investigation, this review aims to provide insights into the therapeutic potential of miRNAs in diagnosing and treating heart diseases, ultimately contributing to improved patient outcomes.

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miR-1

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