Last update 01 Nov 2024

CLCA1

Basic Info

Synonyms
CaCC, CaCC-1, CACC1
+ [8]
Introduction
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.

Related

2
Drugs associated with CLCA1
VS-002
Target
CFTR x CLCA1 x NHE3
Mechanism
CFTR inhibitors [+2]
Active Org.
Nuvara Therapeutics
Originator Org.
Nuvara Therapeutics
Active Indication
Diarrhea
Inactive Indication-
Drug Highest PhaseClinical
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
HG-1011
Target
CLCA1
Mechanism
CLCA1 modulators
Active Org.-
Originator Org.
Human Genome Sciences, Inc.Human Genome Sciences, Inc.
Active Indication-
Inactive Indication
Immune System Diseases [+3]
Drug Highest PhasePending
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
100 Clinical Results associated with CLCA1
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100 Translational Medicine associated with CLCA1
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0 Patents (Medical) associated with CLCA1
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519
Literatures (Medical) associated with CLCA1
31 Dec 2024Experimental Lung Research
CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome
01 Oct 2024Digestive and Liver Disease
CLCA1, a tumour suppressor in hepatocellular carcinoma
01 Oct 2024Digestive and Liver Disease
CLCA1 1 in cancer: A tumor suppressor or oncogene?

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