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Last update 08 May 2025

AQP9

Last update 08 May 2025

Basic Info

Synonyms

AQP-9, AQP9, Aquaglyceroporin-9

+ [5]

Introduction

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:10564231, PubMed:30420639, PubMed:35054513, PubMed:9514918). AQP9 is the primary route for glycerol uptake in hepatocytes, supporting hepatic gluconeogenesis (By similarity). It exhibits broad specificity and may transport various small, non-charged solutes, including carbamides, polyols, purines, and pyrimidines (PubMed:10564231). AQP9 may also facilitate hepatic urea extrusion (PubMed:10564231, PubMed:9514918). Due to its permeability to lactate, AQP9 might participate in the astrocyte-to-neuron lactate shuttle, supplying neurons with energy (PubMed:10564231, PubMed:35054513). Additionally, AQP9 is permeable to arsenite, contributing to arsenic excretion by the liver and providing partial protection against arsenic toxicity (PubMed:10564231). It is also permeable to H2O2 in vivo (PubMed:26837049). Could also be permeable to ammonium (By similarity).

Drugs associated with AQP9

RG-100204

Target

AQP9

Mechanism

AQP9 inhibitors

Active Org.

ApoGlyx AB

Originator Org.

ApoGlyx AB

Active Indication

Sepsis

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with AQP9

100 Translational Medicine associated with AQP9

0 Patents (Medical) associated with AQP9

687

Literatures (Medical) associated with AQP9

01 Apr 2025·Archives of Medical Research

Identifying Genetic Profiles in Peripheral Blood Mononuclear Cells in Women with Polycystic Ovary Syndrome: An Observational Case-Control Study

Article

Author: Osman, Malina Binti ; Ling, King-Hwa ; Heidarzadehpilehrood, Roozbeh ; Pirhoushiaran, Maryam ; Hamid, Habibah Abdul

BACKGROUNDPolycystic ovary syndrome (PCOS) is an endocrine and reproductive condition affecting women of reproductive age, although its expression profiles and molecular pathways are not fully understood.AIMSTo identify the transcriptome expression profiles of peripheral blood mononuclear cells (PBMCs) in women with PCOS and controls. To investigate noninvasive diagnostic biomarkers and potential treatment targets to improve women's fertility.METHODSRNA sequencing (RNA-Seq) was conducted on PBMC samples from six patients with PCOS and six healthy controls. qRT-PCR validation was carried out in 68 subjects. Multivariate logistic regression was performed to assess the combined impact of biomarkers.RESULTSA total of 186 differentially expressed genes (DEG) were found between patients and controls (log₂FC >1, p <0.05). Enrichment analysis revealed cytokine-mediated signaling pathways, cytokine activity, and cytokine-cytokine receptor interaction. RNA sequencing showed consistency with qRT-PCR. Women with PCOS had significantly higher levels of AQP9 (p <0.001), PROK2 (p = 0.001), and S100A12 (p <0.001) expression compared to controls. AQP9 (AUC = 0.77), PROK2 (AUC = 0.71), and S100A12 (AUC = 0.82) adequately discriminated women with PCOS from healthy controls. In addition, multiple logistic regression on biomarkers resulted in a significant diagnostic power with an AUC = 0.89, 95% CI: 0.81-0.97, p <0.0001. Further associations were analyzed between relative gene expression and clinical, anthropometric, hormonal, and ultrasonographic data.CONCLUSIONSDysregulated RNA expression in PBMCs may contribute to an increased risk of PCOS and serve as a potential diagnostic biomarker. The involvement of inflammatory and cytokine-related pathways supports the notion that PCOS is a chronic inflammatory condition.

03 Mar 2025·International Journal of Medical Sciences

Exploring the Shared Diagnostic Genes in IBD and Psoriasis through Bioinformatics and Experimental Assays

Article

Author: Han, Bing ; Han, Lichun ; Li, Shiquan ; Lv, Xiaodan ; Chen, Deyi ; Huang, Zhixi ; Lv, Xiaoping ; Lin, Guangfu ; Gu, Guangli ; Xu, Xiaofang ; Li, Yu

Background: Inflammatory bowel disease (IBD) is a persistent, non-specific inflammation affecting the intestines. Psoriasis is a long-lasting inflammatory disorder of the skin. There is a comorbidity correlation between IBD and psoriasis, but the specific pathogenesis of the comorbidity is unclear. Materials and methods: In this study, we analyzed datasets sourced from the Gene Expression Omnibus (GEO) database, and identified shared genes of IBD and psoriasis through differential expression analysis and weighted gene co-expression network analysis (WGCNA). Then three machine learning algorithms were applied to identify shared diagnostic genes. Next, the validation of shared diagnostic genes was evaluated with ROC curves, with the AUC determined. Subsequently, single sample gene set enrichment analysis (ssGSEA) and immune infiltration analysis were conducted. Furthermore, we obtained potential drugs such as securinine in the Drug Signature Database (DsigDB) and 7 traditional Chinese medicines in the Coremine database, which might have therapeutic effects on the comorbidity of IBD and psoriasis. Finally, we confirmed the expression of the shared diagnostic gene in colitis and psoriasis mice tissues through RT-PCR, Western blot and immunohistochemistry (IHC) methods. Results: The results showed that AQP9 had the highest diagnostic value for two diseases. AQP9 had AUC values of 93.681% for UC, 89.629% for CD,and 78.689% for psoriasis in the internal validation datasets. In the external validation datasets, AQP9 had AUC values of 90.394% for UC, 93.909% for CD,and 82.906% for psoriasis. Immune infiltration analysis and ssGSEA revealed that AQP9 might impact the disease process of IBD and psoriasis by participating in the NF-kappaB signaling pathway, and modulating immune cell differentiation. Furthermore, the expression levels of AQP9 were consistently validated, showing upregulation in IBD and downregulation in psoriasis, compared to the control group. Conclusions: This study revealed the shared diagnostic genes and potential mechanisms of the comorbidity of IBD and psoriasis, providing new directions for future research on exploring the comorbidity mechanisms and treatment targets.

01 Mar 2025·European Journal of Pharmacology

Carvacrol attenuates varicocele-induced infertility in rats

Article

Author: Eidi, Akram ; Mortazavi, Pejman ; Asle-Rousta, Masoumeh ; Ghahreman, Elham ; Asghari, Ahmad

Carvacrol is a common ingredient in the pharmaceutical, cosmetic, and perfume industries. It possesses various pharmaceutical properties including pain relief, anti-cell death, antioxidant, anti-cancer, and anti-inflammatory effects. We investigated the protective impact of carvacrol on infertility caused by varicocele in rats. The animals were assigned to nine groups randomly: control, sham-operated, carvacrol alone at 10, 20, and 40 mg/kg b.w./day, varicocele-induced control, and varicocele-induced rats treated with carvacrol. After thirty days of treatment, the serum was collected to evaluate testosterone levels, and left epididymal sperm samples were obtained to assess sperm quality. Additionally, the left testis was removed for biochemical and histopathological evaluation. The findings demonstrated that carvacrol administration (20 and 40 mg/kg) notably improved sperm quality in rats with varicocele. Furthermore, carvacrol treatment (20 and 40 mg/kg) increased antioxidant levels, reduced MDA levels, decreased AQP₉ expression in testicular tissue, and improved testicular tissue structure. Hence, carvacrol (20 and 40 mg/kg) may serve as a therapeutic agent for male reproductive system disorders, particularly varicocele-related infertility, due to its antioxidant properties and protective effects on testicular function.

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AQP9

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