Last update 01 Nov 2024

NKX3-2

Last update 01 Nov 2024

Basic Info

Synonyms

Bagpipe homeobox protein homolog 1, BAPX1, Homeobox protein NK-3 homolog B

+ [5]

Introduction

Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity).

Drugs associated with NKX3-2

ICM-203

Target

NKX3-2

Mechanism

NKX3-2 modulators [+1]

Active Org.

ICM Biotech Australia Pty Ltd. [+2]

Originator Org.

ICM Co. Ltd.

Active Indication

Osteoarthritis, Knee [+2]

Inactive Indication-

Drug Highest PhasePhase 1/2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with NKX3-2

NCT05454566 / Not yet recruitingPhase 1/2

A Single Dose Escalation Study of Intra-Articular ICM-203 in Subjects With Kellgren-Lawrence Grade 2 or Grade 3 Osteoarthritis of the Knee

The purpose of this study is to determine the safety, tolerability, and activity of ICM-203, a recombinant adeno-associated viral (AAV) vector that expresses a therapeutic gene that promotes cartilage formation, reduces joint inflammation and pain, as well as improves joint physical function, by injecting escalating doses of ICM-203 into the knee of subjects with mild to moderate knee osteoarthritis (OA).
Approximately 6 to 18 subjects will be enrolled into 3 successive dose-escalating groups in a 3+3 study design, whereby 3 study subjects in each group will be dosed sequentially with ICM-203 and 3 additional subjects will be dosed at the same dose level if a dose limiting toxicity (DLT) occurs in any of the first 3 subjects.

Start Date15 Nov 2024

Sponsor / Collaborator

ICM Co. Ltd.

NCT05752032 / Enrolling by invitationNot Applicable

A Long Term Follow-up Study of Subjects Who Received ICM-203 or Matching Placebo

This is an observational study of the long term safety and efficacy of ICM-203.

Start Date16 Mar 2023

Sponsor / Collaborator

ICM Co. Ltd.

NCT04875754 / RecruitingPhase 1/2

A Phase 1/2a, Double-Blind, Placebo-Controlled Single Dose Escalation Study of Intra-Articular ICM 203 in Subjects With Kellgren-Lawrence Grade 2 or Grade 3 Osteoarthritis of the Knee

Start Date17 Mar 2022

Sponsor / Collaborator

ICM Biotech Australia Pty Ltd.

100 Clinical Results associated with NKX3-2

100 Translational Medicine associated with NKX3-2

0 Patents (Medical) associated with NKX3-2

138

Literatures (Medical) associated with NKX3-2

01 Jul 2024·Open Biology

Pseudogenization of NK3 homeobox 2 ( Nkx3.2 ) in monotremes provides insight into unique gastric anatomy and physiology

Article

Author: Dann, Jackson ; Qu, Zhipeng ; Shearwin-Whyatt, Linda ; van der Ploeg, Rachel ; Grützner, Frank

The enzymatic breakdown and regulation of food passage through the vertebrate antral stomach and pyloric sphincter (antropyloric region) is a trait conserved over 450 million years. Development of the structures involved is underpinned by a highly conserved signalling pathway involving the hedgehog, bone morphogenetic protein and Wingless/Int-1 (Wnt) protein families. Monotremes are one of the few vertebrate lineages where acid-based digestion has been lost, and this is consistent with the lack of genes for hydrochloric acid secretion and gastric enzymes in the genomes of the platypus ( Ornithorhynchus anatinus ) and short-beaked echidna ( Tachyglossus aculeatus ) . Furthermore, these species feature unique gastric phenotypes, both with truncated and aglandular antral stomachs and the platypus with no pylorus. Here, we explore the genetic underpinning of monotreme gastric phenotypes, investigating genes important in antropyloric development using the newest monotreme genomes (mOrnAna1.pri.v4 and mTacAcu1) together with RNA-seq data. We found that the pathway constituents are generally conserved, but surprisingly, NK3 homeobox 2 ( Nkx3.2 ) was pseudogenized in both platypus and echidna. We speculate that the unique sequence evolution of Grem1 and Bmp4 sequences in the echidna lineage may correlate with their pyloric-like restriction and that the convergent loss of gastric acid and stomach size genotypes and phenotypes in teleost and monotreme lineages may be a result of eco-evolutionary dynamics. These findings reflect the effects of gene loss on phenotypic evolution and further elucidate the genetic control of monotreme stomach anatomy and physiology.

01 Jan 2024·Molecular Reproduction and Development

Proteomic analysis of boar seminal plasma: Putative markers for fertility based on capacity of semen preservation at 17°C

Article

Author: Nogueira, Fábio C S ; Bustamante-Filho, Ivan C ; Bortolozzo, Fernando P ; Evaristo, Joseph A M ; Ulguim, Rafael R ; Mellagi, Ana P G ; Timmers, Luís F S M ; Lucca, Matheus S ; Gianluppi, Rafael D F ; Wentz, Ivo

AbstractBoar seminal plasma (SP) proteins were associated with differences on sperm resistance to cooling at 17°C. However, information about seminal plasma proteins in boars classified by capacity of semen preservation and in vivo fertility remains lacking. Thus, the objective was to evaluate the SP proteome in boars classified by capacity of semen preservation and putative biomarkers for fertility. The ejaculates from high‐preservation (HP) showed higher progressive motility during all 5 days than the low‐preservation (LP) boars. There was no difference for farrowing rate between ejaculates from LP (89.7%) and HP boars (88.4%). The LP boars presented lower total piglets born (14.0 ± 0.2) than HP (14.8 ± 0.2; p < 0.01). A total of 257 proteins were identified, where 184 were present in both classes of boar, and 41 and 32 were identified only in LP and HP boars, respectively. Nine proteins were differently expressed: five were more abundant in HP (SPMI, ZPBP1, FN1, HPX, and C3) and four in LP boars (B2M, COL1A1, NKX3‐2, and MPZL1). The HP boars had an increased abundance of SP proteins related to sperm resistance and fecundation process which explains the better TPB. LP boars had a higher abundance of SP proteins associated with impaired spermatogenesis.

06 Oct 2023·Medicina (Kaunas, Lithuania)

Comprehensive Analysis of NKX3.2 in Liver Hepatocellular Carcinoma by Bigdata.

Article

Author: Choi, Euncheol ; Lee, Jae-Ho ; Park, Jong-Ho ; Bae, An-Na ; Kim, Jongwan

Background and Objectives: The gene NKX3.2 plays a role in determining cell fate during development, and mutations of NKX3.2 have been studied in relation to human skeletal diseases. However, due to the lack of studies on the link between NKX3.2 and cancer, we aimed to provide insights into NKX3.2 as a new prognostic biomarker for liver hepatocellular carcinoma (LIHC). Materials and Methods: The clinical significance of LIHC was investigated using open gene expression databases. We comprehensively analyzed NKX3.2 expression in LIHC using Gene Expression Profiling Interactive Analysis 2, Tumor Immune Estimation Resource (TIMER), and Kaplan-Meier plotter databases. Then, we investigated the association between NKX3.2 expression and tumor-infiltrating immune cells (TIICs). Results: NKX3.2 expression was higher in the primary tumor group compared to the normal group, and expression was higher in fibrolamellar carcinoma (FLC) compared to other subtypes. When the prognostic value of NKX3.2 was evaluated, highly expressed NKX3.2 significantly improved the overall survival and had an unfavorable prognosis. In addition, NKX3.2 expression was associated with immune cell infiltration. Patients with low gene expression and high macrophage expression had a poorer survival rate than those with low NKX3.2 and low macrophage expression (p = 0.0309). Conclusions: High NKX3.2 expression may induce poorer prognosis in LIHC. In addition, these findings can be used as basic data due to the lack of available related research. However, further in vivo studies are essential to gain a deeper understanding of the biological role of NKX3.2 in LIHC and its potential implications for cancer development and progression.

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NKX3-2

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