[Translation] A Phase II, double-blind, placebo-controlled, randomized withdrawal study to evaluate the safety and efficacy of XG005 in subjects with cancer-induced bone pain (CIBP)

评估XG005与安慰剂相比在癌性骨痛中的镇痛效果。评估XG005在癌性骨痛受试者中的安全性。评估XG005对生活质量（QoL）测量结果的影响。

[Translation]

To evaluate the analgesic efficacy of XG005 compared to placebo in cancer bone pain. To evaluate the safety of XG005 in subjects with cancer bone pain. To evaluate the effect of XG005 on quality of life (QoL) measures.

Start Date25 Dec 2023

Sponsor / Collaborator

Xgene Pharmaceutical, Inc.

NCT06017999 / RecruitingPhase 2/3

A Randomized, Double-Blind, Placebo Controlled Trial to Evaluate the Safety and Efficacy of XG005 Tablets in Subjects Undergoing Bunionectomy

This study will evaluate the safety, efficacy, and PK of low dose (750 mg) and high-dose (1250 mg) XG005 oral tablets compared with placebo in subjects undergoing bunionectomy. Subjects will be confined in the clinic from check-in through 72 hours post-surgery to monitor subject safety.

Start Date08 Aug 2023

Sponsor / Collaborator

Xgene Pharmaceutical, Inc.

CTR20222406 / RecruitingPhase 2

一项在疼痛性膝骨关节炎受试者中评价XG005的安全性和疗效的IIb期、随机、双盲、安慰剂对照和平行组研究

[Translation] A Phase IIb, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the safety and efficacy of XG005 in subjects with painful knee osteoarthritis

评估两种剂量水平的XG005与安慰剂相比的镇痛效果评估XG005在疼痛性膝骨关节炎（OA）受试者中的安全性评估XG005对膝关节功能和生活质量（QoL）测量指标的影响评估XG005的药代动力学

[Translation]

To evaluate the analgesic efficacy of two dose levels of XG005 compared to placebo To evaluate the safety of XG005 in subjects with painful knee osteoarthritis (OA) To evaluate the effects of XG005 on knee function and quality of life (QoL) measures To evaluate the pharmacokinetics of XG005

Start Date28 Nov 2022

Sponsor / Collaborator

Xgene Pharmaceutical, Inc.

100 Clinical Results associated with CACNA2D1 x COX

100 Translational Medicine associated with CACNA2D1 x COX

0 Patents (Medical) associated with CACNA2D1 x COX

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