PARP7

OR YEHUDA, Israel, May 15, 2023 /PRNewswire/ -- Peregrine Ventures, Israel's leading investment firm dedicated to supporting life changing healthcare opportunities, today celebrated the transformative accomplishments of their high-performing portfolio of medical technology companies. The Q1 2023 portfolio achievement highlights include a $25 million equity investment from Pfizer, entering a clinical trial agreement with Merck & Co, and the successful preliminary results of its first-in-human clinical study. "Peregrine prides itself on its ability to identify and invest in first-in-class and best-in-class healthcare companies," said Eyal Lifschitz, Managing Partner and Co-founder of Peregrine Ventures. "These accomplishments are the truest example of why our work is important, and we are proud to be a part of these companies' success stories. We look forward to seeing their future accomplishments on the path to becoming widely accessed, game-changing global healthcare opportunities." Q1 2023 achievements include: BioProtect, a technology platform company that provides innovative bioabsorbable spacers, realized successful Phase I/II clinical study results of company's BioProtect Balloon Implant System. In treating rectal toxicity that is often a result of prostate cancer radiation therapy, the balloon spacer is safe, does not affect patient quality of life, and preserves local control in patients with intermediate-high risk. EndoStream Medical enrolled the first patient in the company's U.S. clinical trial to evaluate the Nautilus™ Intrasaccular System, a revolutionary technology for the treatment of cerebral aneurysms. The Nautilus is a self-conforming intrasaccular flow diverter, maximizing neck coverage and enhancing coil stability, to optimize intrasaccular thrombosis and enable progressive occlusion of the aneurysm. The medical technology was also featured on the cover of Interventional Neuroradiology (INR). Levation Pharma, a pharmaceutical company focused on the development of new therapeutics for the ophthalmology and aesthetic space, received FDA clearance to initiate Phase I and II of LEV102, a proprietary aqueous gel. The clinical trial is designed to determine the preliminary safety and efficacy signals for LEV102 as a potential treatment for drooping of the upper eye lid, Acquired Blepharoptosis, in adults. Nectin Therapeutics, a biotechnology company developing novel targeted immunotherapies that address resistance to approved immune oncology treatments, entered a clinical trial agreement with Merck & Co. The trail will assess the safety and efficiency of Nectin's first-in-class anti-PVR treatment as it is used in combination with Merck's anti-PD1 therapy, KEYTRUDA® for the treatment of metastatic solid tumors. Restore Medical saw successful preliminary results of its first-in-human clinical study of the CONTRABAND™ system, the world's first and only Pulmonary Artery Banding transcatheter implant designed to treat left ventricle failure by restoring the heart's efficient structure. The six-month and one-year results of the study demonstrated that the implantation procedure of the CONTRABAND™ device was safe for all participants and improved the quality of life for those treated. Ribon Therapeutics, a clinical-stage biotechnology company developing therapeutics to target stress support pathways, received a $25 million equity investment from Pfizer. This additional funding will support the clinical development of Ribon's potentially first-in-class oral small molecule programs in oncology (RBN-2397, a PARP7 inhibitor) and immunology (RBN-3143, a PARP14 inhibitor). Ribon Therapeutics also announced the dosing of the first patient in the open-label cohort of patients with moderate-to-severe atopic dermatitis. This testing is part of the company's Phase 1 clinical study of RBN-3143, a first-in-class, oral small molecule inhibitor of PARP14, for the treatment of a range of inflammatory diseases. In addition to these portfolio achievements, Peregrine Ventures has made several new investments in early- and seed-stage companies in the bio-convergence field for incubation in their world-class MedTech incubator. Companies include: OncoRedox, a point-of-care testing device that utilizes AI to detect cancer from urine samples; CTC Therapeutics, an innovative technology for collecting tumor cells which applies a unique manipulation to activate an immune response to attack the cancer cells; EViCure, a unique off-the-shelf anti-tumor exosome treatment that exerts anti-tumor effects; and MilCo, a food tech startup that aims to produce animal-free dairy products by producing functional milk proteins in yeast. DairyX products will be healthier and more accessible with the same taste and cost of traditional dairy products. ABOUT PEREGRINE VENTURES Peregrine Ventures, Israel's first dedicated healthcare fund, is committed to improving patients' quality of life by investing in and supporting game-changing healthcare opportunities. As a leading global life science venture capital fund, Peregrine invests throughout a company's life cycle to help facilitate growth and success and offers creative business solutions to suit the needs of its portfolio companies. From seed-stage opportunities to more mature companies, Peregrine's specifically defined funds offer portfolio companies complete, end-to-end investment solutions that have helped bring healthcare innovations to fruition for over 20 years. Peregrine's robust portfolio includes fast growing global companies, in the fields of biotech, medical devices, and digital health. Peregrine's mature funds maintain their strong position in the upper quartile of the industry's leading benchmarks (Number of exits, DPI, IRR, etc.). For more information, please visit . CONTACT: SARA KLEIN, 212-805-3018 [email protected] SOURCE Peregrine Ventures

Duke Street Bio, a UK-based biotech focusing on the discovery of novel precision medicine-based cancer therapies, today announced the strengthening of its executive leadership team with the appointment of Dónal Landers, MB BCh BAO, MBA, DPM, FFPM as Chief Medical Officer. Dr Landers is a highly experienced pharmaceutical physician with a proven track record of leading multiple molecules through early oncology clinical development. Dr Landers combines science, medicine with an entrepreneurial flair to drive translational and clinical drug development in oncology. After obtaining his primary medical degree from Trinity College, Dublin, Dónal spent several years practicing hospital clinical medicine. He undertook an MBA at University College Dublin before transitioning to senior management at St. James’s Hospital. Dónal then co-founded his own health informatics company developing ‘patient-centric’ mobile technology solutions, enabling patients to collect and monitor their own health data. After a number of years in various technology start-up companies, he joined PricewaterhouseCoopers as a specialist senior consultant and became sectoral lead for the healthcare and pharmaceutical group in Strategy Advisory. Dónal joined AstraZeneca (AZ) in 2010 as pharmaceutical physician in Early Clinical Development (ECD) where he was Senior Director Physician and led multiple targeted therapy clinical programs, including AZ’s first large multi-drug oncology Phase Ib ‘umbrella’ study in urothelial cancer (BISCAY). Most recently Dónal set up his own specialist consulting business, DeLondra Oncology, focusing on candidate selection to Phase II development, specialising in both early clinical and translational drug development in oncology. Dónal was also co-founder and Strategic Director of the Digital Experimental Cancer Medicine Team based at Cancer Research UK Manchester Institute. This research team was setup to provide next generation patient cancer care using data-driven evidence to enable the transformation of clinical decision-making, the evolution of the role of the patient and the improvement of patient outcomes. “The addition of Dr Landers comes at an exciting time for Duke Street Bio as we transition our best-in-class PARP1-selective and PARP7 inhibitor programs into the clinic. We are delighted to have him join the team.” said Alan Wise, CEO Duke Street Bio. About Duke Street Bio Duke Street Bio is privately held biotechnology company focused on the development of innovative treatments in oncology. The precision medicine approach in our PARP1-selective inhibitor program exploits tumour genetic vulnerabilities whilst our PARP7 inhibitor program harnesses the natural power of the body’s immune system to fight cancer. We are committed to developing best-in-class products that fulfil major unmet medical needs.

BEIJING, SHANGHAI and BOSTON, March 22, 2023 /PRNewswire/ -- Jacobio Pharma (1167.HK) announced its 2022 annual results. R&D investment was RMB530 million, showing an increase of 26% compared with 2021. The revenue was RMB95.7 million, which was generated from an out-licensing deal. Jacobio Pharma also announced its recent business progress and expected milestones. Dr. Wang Yinxiang, Chairman and CEO of Jacobio Pharma, said: "Jacobio's business made satisfying progress in 2022, although all biotechnology companies had to deal with challenges created by a bleak macroeconomic environment. We continue to accelerate clinical projects and expand pipelines through in-house R&D. The previous hard work is about to enter the harvest period. Next, we will focus on the two major R&D areas of targeted therapy and iADC, and further implement the strategy of 'aiming the global market and the key projects are among the top three in the world'." Development of core clinical stage products KRAS G12C inhibitor Glecirasib (JAB-21822) Monotherapies - The pivotal trial in patients with NSCLC harboring KRAS G12C mutation was approved by the CDE in September 2022. The NDA application is expected to be submitted in 2023 Q4. - In December 2022, Glecirasib has been granted BTD (Breakthrough Designation) for the second line and above treatment of advanced or metastatic NSCLC patients with KRAS G12C mutation by the CDE. - Jacobio has received the IND approval of Glecirasib monotherapy for a Phase I/IIa trial in first line NSCLC patients who have KRAS G12C and STK-11 co-mutation and the first patient was dosed in August 2022. - In patients with CRC, PDAC and other solid tumors treated with Glecirasib monotherapy, promising efficacy signals were observed. The potential global development plan in other solid tumors will be discussed with China and U.S. regulatory authorities. In combination with EGFR mAb - In China, the enrollment of the Phase I/IIa trial of Glecirasib in combination with an anti-EGFR antibody cetuximab in patients with CRC was completed in February 2023. Pivotal trial is expected to be initiated in 2023 Q4 in China. - In October 2022, Jacobio has entered into a clinical trial collaboration agreement with Merck on clinical study of Glecirasib in combination with Merck's Erbitux® (cetuximab). Merck will provide cetuximab for clinical trials in China and Europe under the collaboration agreement. SHP2 inhibitors: JAB-3312 & JAB-3068 In combination with KRAS G12C inhibitor - In China, the Phase I/IIa clinical trial of JAB-3312 in combination with our KRAS G12C inhibitor Glecirasib to treat KRAS G12C naïve and resistant patients is actively recruiting. - Jacobio has completed the global first dose of Phase II clinical trial for the combination of JAB-3312 and a KRAS G12C inhibitor Sotorasib. - The results of JAB-3312 in combination with Glecirasib in pre-clinical cancer models were presented in a poster session in 2022 ESMO Asia Congress. Development of other products - JAB-8263 (BET inhibitor): The Phase I dose escalation portion in solid tumors and hematological malignancies is ongoing in the U.S. and China simultaneously. RP2D is expected to be determined in the second half of 2023. - JAB-2485 (Aurora A inhibitor): In China, the IND application for a Phase I/IIa trial was approved by the CDE in October 2022. The first patient was dosed in January 2023 in the U.S. This is the first global trial fully managed by Jacobio's internal clinical team, which demonstrates our global clinical development capabilities. - JAB-BX102 (CD73 mAb): The Phase I/IIa dose escalation or expansion trial for JAB-BX102 in advanced solid tumors was initiated in September 2022. RP2D is expected to be determined in the second half of 2024. Jacobio has entered into a clinical collaboration with Merck & Co., Inc., Rahway, NJ, USA to evaluate the combination of Jacobio's CD73 mAb JAB-BX102 in combination with Merck & Co., Inc., Rahway, NJ, USA's anti-PD-1 therapy, KEYTRUDA® (pembrolizumab). - JAB-24114 (GUE inhibitor): The IND application was approved by China CDE in March 2023. - Jacobio has submitted the IND applications of JAB-BX300 (LIF mAb) to the NMPA in January 2023. - The IND applications of JAB-23400 (KRASmulti inhibitor), JAB-30300 (P53 Y220C corrector) and JAB-26766 (PARP7 inhibitor) will be submitted this year. - Candidate of JAB-X1800, Jacobio's in-house CD73-STING iADC, was nominated in the first quarter of 2023. Data publication plan in 2023 - AACR 2023 (accepted): The preclinical studies of KRASmulti inhibitor JAB-23425, CD73-STING iADC JAB-X1800, and Aurora kinase A inhibitor JAB-2485. - ASCO 2023 (submitted): The clinical data of Glecirasib in combination with Cetuximab in patients with CRC. - ESMO 2023 (planed): The clinical data of SHP2 inhibitor JAB-3312 in combination with Glecirasib. - 2023 H2-2024 H1 (planed): Glecirasib monotherapy in PDAC and other solid tumors - expect to read out preliminary data for this study. In 2022, Jacobio owned 280 patents or patent applications that are filed globally, the number increased 60% compared with 2021. The new R&D headquarters in Beijing will be officially used in May 2023, with a total area of 22,000 square meters. In March 2023, Jacobio was selected as the first batch of transferred Hong Kong Listed company under the Shanghai-Hong Kong Stock connect. Jacobio is able to continuously invest in its pipelines with cash reserve. As of December 31, 2022, Jacobio has 1.3 billion yuan cash and cash equivalent. In February 2023, Jacobio raised HKD159 million through public placing. Conference Call Information Jacobio Pharma will hold a live conference call at 9:00 AM March 23 2023 Beijing time. Participants please register in advance through About Jacobio Jacobio Pharma (1167.HK) is committed to developing and providing new and innovative products and solutions to improve people's health. Our pipeline revolves around novel molecular targets on six major signaling pathways: KRAS, immune checkpoints, tumor metabolism, P53, RB and MYC. We aim for our key projects to be among the top three in the world. Our vision is to become a global leader recognized for our impact in drug R&D together with our partners. Jacobio has R&D centers in Beijing, Shanghai and Boston with our Induced Allosteric Drug Discovery Platform (IADDP) and our iADC Platform. Forward-Looking Statements This news release may contain certain forward-looking statements that are, by their nature, subject to significant risks and uncertainties. The words "anticipate", "believe", "estimate", "expect", "intend" and similar expressions, as they relate to the Company, are intended to identify certain of such forward-looking statements. The Company does not intend to update these forward-looking statements regularly. These forward-looking statements are based on the existing beliefs, assumptions, expectations, estimates, projections and understandings of the management of the Company with respect to future events at the time these statements are made. These statements are not a guarantee of future developments and are subject to risks, uncertainties and other factors, some of which are beyond the Company's control and are difficult to predict. Consequently, actual results may differ materially from information contained in the forward-looking statements as a result of future changes or developments in our business, the Company's competitive environment, and political, economic, legal and social conditions in China. The Company, the Directors and the employees of the Company assume (a) no obligation to correct or update the forward-looking statements contained in this site; and (b) no liability in the event that any of the forward-looking statements does not materialize or turn out to be incorrect. SOURCE Jacobio Pharma